m7G-modified mt-tRF3b-LeuTAA regulates mitophagy and metabolic reprogramming via SUMOylation of SIRT3 in chondrocytes [0.03%]
滑膜软骨细胞线粒体tRF3b-LeuTAA通过SIRT3的SUMO化调节自噬和代谢重编程
Dianbo Long,Zengfa Deng,Xiaoyi Zhao et al.
Dianbo Long et al.
N7-methylguanosine (m7G) modification is one of the most prevalent RNA modifications, and methyltransferase-like protein-1 (METTL1) is a key component of the m7G methyltransferase complex. METTL1-catalyzed m7G as a new RNA modification path...
Optimization of culture conditions to generate vascularized multi-lineage liver organoids with structural complexity and functionality [0.03%]
优化生成具有结构复杂性和功能性的血管化多谱系肝器官的培养条件
Kyun Yoo Chi,Gyeongmin Kim,Hyojin Kim et al.
Kyun Yoo Chi et al.
Hepatic organoids (HOs), primarily composed of hepatobiliary cells, do not represent the pathogenesis of liver diseases due to the lack of non-parenchymal cells. Multi-lineage liver organoids (mLOs) containing various cell types found in th...
Engineered bacterium-metal-organic framework biohybrids for boosting radiotherapy with multiple effects [0.03%]
用于增强放疗的工程细菌-金属有机框架生物杂化材料
Jia-Wei Wang,Ping Ji,Jin-Yue Zeng et al.
Jia-Wei Wang et al.
Hypoxia and lactate-overexpressed tumor microenvironment always lead to poor therapeutic effect of radiotherapy. Here, platinum nanoparticles-embellished hafnium metal-organic framework (Hf-MOF-Pt NPs) were elaborately integrated with Shewa...
Endothelium-targeted NF-κB siRNA nanogel for magnetic resonance imaging and visualized-anti-inflammation treatment of atherosclerosis [0.03%]
针对内皮细胞的NF-κBsiRNA纳米凝胶用于动脉粥样硬化的磁共振成像及可视化抗炎治疗
Yuanyuan Guo,Fujun Wang,Sunli Wan et al.
Yuanyuan Guo et al.
Atherosclerosis-induced lethal cardiovascular disease remains a severe healthcare threat due to the limited drug efficiency and untimely prediction of high-risk events caused by inadequate target specificity of medications, incapable recogn...
A Sr@Ag-based spatiotemporal and step-release scaffold against chronic osteomyelitis, fabricated by coaxial 3D-printing [0.03%]
一种基于Sr@Ag的时空和分步释放支架对抗慢性骨髓炎，通过同轴3D打印制造而成
Jingyun Wang,Qin Zhang,Hetong Wang et al.
Jingyun Wang et al.
Chronic osteomyelitis (OM) represents a severe and persistent infectious bone disease. Effective treatment requires controlled anti-inflammatory releases and bone regeneration across disease phases. A Sr@Ag-based scaffold was successfully p...
Engineering cell membrane-camouflaged COF-based nanosatellite for enhanced tumor-targeted photothermal chemoimmunotherapy [0.03%]
工程化细胞膜伪装的COF基纳米卫星用于增强肿瘤靶向光热化疗免疫疗法
Dan Lin,Wenxin Lv,Min Qian et al.
Dan Lin et al.
Dendritic cells (DCs) activation is crucial for regulating the antitumor immune response. However, the tumor's immunosuppressive environment significantly impedes antigen presentation and DCs maturation, thereby limiting the effectiveness o...
Cell calcification reverses the chemoresistance of cancer cells via the conversion of glycolipid metabolism [0.03%]
细胞钙化通过糖脂代谢的转换逆转癌细胞的化学耐药性
Lihong Zhang,Yandi Sun,Yindan Lin et al.
Lihong Zhang et al.
Drug resistance is an inherent challenge during cancer chemotherapy. Cancer cells favor fatty acid metabolism through metabolic reprogramming to achieve therapeutic resistance. However, an effective approach to overcoming the switch from gl...
Anti-pyroptosis biomimetic nanoplatform loading puerarin for myocardial infarction repair: From drug discovery to drug delivery [0.03%]
负载葛根素抗细胞炎性焦亡的仿生纳米递药平台用于心梗修复：从药物发现到药物传输研究
Kun Wang,Yu Sun,Ke Zhu et al.
Kun Wang et al.
Pyroptosis is a critical pathological mechanism implicated in myocardial damage following myocardial infarction (MI), and the crosstalk between macrophages and pyroptotic cardiomyocytes presents a formidable challenge for anti-pyroptosis th...
Poly(β-amino ester) polymer library with monomer variation for mRNA delivery [0.03%]
基于单体变化的用于mRNA递送的聚β氨基酯聚合物库
Hong Lyun Kim,Gurusamy Saravanakumar,Seowon Lee et al.
Hong Lyun Kim et al.
Non-viral vectors for mRNA delivery primarily include lipid nanoparticles (LNPs) and polymers. While LNPs are known for their high mRNA delivery efficiency, they can induce excessive immune responses and cause off-target effects, potentiall...
Engineering probiotic biohydrogen micro-factories to initiate reductive stress for boosting tumor vulnerability [0.03%]
工程益生菌生物氢微工厂启动还原性压力以增强肿瘤敏感性
Jie Jiang,Yuhao Lu,Xinyi Zheng et al.
Jie Jiang et al.
Disruption of redox homeostasis profoundly affects cellular metabolism and activities. While oxidative stress is extensively studied in cancer therapies, research on reductive stress remains in its infancy. Molecular hydrogen (H2), a well-k...