Exosome-decorated bio-heterojunctions reduce heat and ROS transfer distance for boosted antibacterial and tumor therapy [0.03%]
外泌体装饰生物异质结减少热和ROS传输距离以增强抗菌和抗肿瘤疗法
Yanni Li,Lin Chen,Yonghao Chen et al.
Yanni Li et al.
Photothermal and photodynamic therapies represent effective modalities for combatting bacteria and tumor cells. However, therapeutic outcomes are constrained by limitations related to the heat and reactive oxygen species (ROS) transfer dist...
3D printing incorporating gold nanozymes with mesenchymal stem cell-derived hepatic spheroids for acute liver failure treatment [0.03%]
结合金纳米酶和间充质干细胞来源的肝类器官的三维打印技术在急性肝功能衰竭治疗中的应用研究
Yuanyuan Jin,Jiabin Zhang,Xiaodie Chen et al.
Yuanyuan Jin et al.
Acute liver failure (ALF) is a highly fatal disease, necessitating the advancement and optimization of alternative therapeutic strategies to benefit patients awaiting liver transplantation. In this study, we innovatively established the ant...
Targeting senescence with radioactive 223Ra/Ba SAzymes enables senolytics-unlocked One-Two punch strategy to boost anti-tumor immunotherapy [0.03%]
放射性223Ra / Ba SAzyme靶向衰老，实现解锁Senolytic的组合策略以增强抗肿瘤免疫疗法
Jiajia Zhang,Shenghong Zhang,Chao Cheng et al.
Jiajia Zhang et al.
Senescent cells are characterized by a persistent cessation of their cell cycle, rendering them valuable targets for anti-tumor strategies in cancer treatment. Numerous studies have explored induced senescence as a promising approach in tum...
Genetically modified extracellular vesicles loaded with activated gasdermin D potentially inhibit prostate-specific membrane antigen-positive prostate carcinoma growth and enhance immunotherapy [0.03%]
负载活化Gasdermin D的基因工程外泌体可能抑制前列腺特异性膜抗原阳性前列腺癌生长并增强免疫治疗效果
Ke Gao,Wenjin Xi,Jianxin Ni et al.
Ke Gao et al.
Prostate cancer (PCa) is associated with poor immunogenicity and lymphocytic infiltration, and immunotherapy effective against PCa remains unavailable. Pyroptosis, a novel immunotherapeutic modality for cancer, promotes systemic immune resp...
Matrix stiffening from collagen fibril density and alignment modulates YAP-mediated T-cell immune suppression [0.03%]
胶原纤维密度和排列通过YAP介导的T细胞免疫抑制使矩阵硬化
Jiranuwat Sapudom,Aseel Alatoom,Paul Sean Tipay et al.
Jiranuwat Sapudom et al.
T-cells are essential components of the immune system, adapting their behavior in response to the mechanical environments they encounter within the body. In pathological conditions like cancer, the extracellular matrix (ECM) often becomes s...
Albumins constrainting the conformation of mitochondria-targeted photosensitizers for tumor-specific photodynamic therapy [0.03%]
白蛋白结合素限制线粒体靶向光敏剂构象用于肿瘤特异性光动力疗法
Bin Fang,Hua Bai,Jiaxin Zhang et al.
Bin Fang et al.
Tumor ablation Preclinical organelle-targeted phototherapies have effectively achieved tumor photoablation for regenerative biomedical applications in cancer therapies. However, engineering effective phototherapy drugs with precise tumor-lo...
A MnO2 nanosheets doping double crosslinked hydrogel for cartilage defect repair through alleviating inflammation and guiding chondrogenic differentiation [0.03%]
一种用于软骨修复的MnO2纳米片掺杂双交联水凝胶，可通过抗炎和引导成软骨分化来实现损伤修复
Feilong Zhao,Zhibo Jia,Liyang Zhang et al.
Feilong Zhao et al.
The inflammatory microenvironment and inferior chondrogenesis are major symptoms after cartilage defect. Although various modifications strategies associated with hydrogels exhibit remarkable capacity of pro-cartilage regeneration, the adve...
Neutrophils exhibit flexible migration strategies and trail formation mechanisms on varying adhesive substrates [0.03%]
中性粒细胞在不同黏附基底物上表现出灵活的迁移策略和踪迹形成机制
Wenbo Gao,Xiaoning Zhang,Wenhui Hu et al.
Wenbo Gao et al.
Substrate anchorage is essential for cell migration, and actin polymerization at cell front and myosin contractility at cell rear are known to govern cell forward movement. Yet their differential driving strategies for neutrophil migration ...
Anaerobic bacterial metabolism responsive microspheres for bacterial embolization cancer therapy [0.03%]
用于细菌栓塞癌症治疗响应厌氧菌代谢的微球体
Hyunjun Choi,Bongseo Choi,Dong-Hyun Kim
Hyunjun Choi
Anaerobic bacteriolytic cancer therapy, whether delivered locally or systemically, frequently encounters challenges related to limited colonization within hypoxic pockets of central tumors and activation of innate immunity. Herein we have d...
Electrically-driven drug delivery into deep cutaneous tissue by conductive microneedles for fungal infection eradication and protective immunity [0.03%]
用于真菌感染根除和保护性免疫的导电微针电驱动深部组织药物输送
Sumanta Ghosh,Mengjia Zheng,Jiahui He et al.
Sumanta Ghosh et al.
Fungal infections affect over 13 million people worldwide and are responsible for 1.5 million deaths annually. Some deep cutaneous fungal infections may extend the dermal barriers to cause systemic infection, resulting in substantial morbid...