Ru single-atom nanozymes targeting ROS-ferroptosis pathways for enhanced endometrial regeneration in intrauterine adhesion therapy [0.03%]
用于增强宫腔粘连治疗子宫内膜修复的ROS-铁死亡途径靶向RU单原子纳米酶
Yuxiang Liang,Jian Meng,Zhaowei Yu et al.
Yuxiang Liang et al.
Intrauterine adhesion (IUA) presents a significant challenge in gynecology, characterized by excessive fibrosis and compromised reproductive function, leading to severe infertility. Although biocompatible hydrogels integrated with stem cell...
VEGF-loaded ROS-responsive nanodots improve the structure and function of sciatic nerve lesions in type II diabetic peripheral neuropathy [0.03%]
ROS响应的载VEGF纳米点改善II型糖尿病外周神经病变坐骨神经损伤的结构和功能
Xiaolan Ou,Ze Wang,Daojiang Yu et al.
Xiaolan Ou et al.
Diabetic peripheral neuropathy (DPN) is a prevalent complication of diabetes mellitus (DM), significantly contributing to the risk of amputation and mortality. Reactive oxygen species (ROS) can induce both neurological and structural harm t...
Corrigendum to 'Enhancing CAR-T cell therapy against solid tumor by drug-free triboelectric immunotherapy' [Biomaterials 314 (2025) 122871] [0.03%]
关于“通过无药物摩擦电免疫疗法增强CAR-T细胞治疗固体肿瘤”一文的勘误[Biomaterials 314 (2025) 122871]
Haimei Li,Zichen Wang,Yulin Hu et al.
Haimei Li et al.
Published Erratum
Biomaterials. 2025 Apr:315:122927. DOI:10.1016/j.biomaterials.2024.122927 2025
Priming of cancer-immunity cycle by alleviating hypoxia-induced ferroptosis resistance and immunosuppression [0.03%]
通过缓解缺氧诱导的铁死亡抵抗和免疫抑制来启动抗癌免疫循环
Yun Chen,Mengxuan Zuo,Deblin Jana et al.
Yun Chen et al.
Stimulating a robust cancer-immunity cycle (CIC) holds promising potential for eliciting potent and enduring immune responses for cancer immunotherapy. However, designing a therapeutic nanomaterial capable of both enhancing tumor immunogeni...
Jiali Liu,Jiying Liu,Yaxin Wang et al.
Jiali Liu et al.
Immunotherapy is initially envisioned as a powerful approach to train immune cells within the tumor microenvironment (TME) and lymphoid tissues to elicit strong anti-tumor responses. However, clinical cancer immunotherapy still faces challe...
Charge regulated pH/NIR dual responsive nanoplatforms centered on cuproptosis for enhanced cancer theranostics [0.03%]
基于铜死亡的电荷调节pH/NIR双响应纳米平台用于增强癌症诊疗
Bin Sun,Wei Gao,Xinyuan Yu et al.
Bin Sun et al.
Multifunctional nanoplatforms capable of simultaneously executing multimodal therapy and imaging functions are of great potentials for cancer theranostics. We present an elegantly designed, easy-to-fabricate poly(acrylic acid)/mesoporous ca...
Molybdenum nanodots act as antioxidants for photothermal therapy osteoarthritis [0.03%]
用于光热治疗骨关节炎的二硫化钼纳米点抗氧化作用研究
Guang Shi,Shenghui Lan,Qi Zhang et al.
Guang Shi et al.
Osteoarthritis (OA) manifests as the degradation of cartilage and remodeling of subchondral bone. Restoring homeostasis within the joint is imperative for alleviating OA symptoms. Current interventions primarily target singular aspects, suc...
Biologically logic-gated Trojan-horse strategy for personalized triple-negative breast cancer precise therapy by selective ferroptosis and STING pathway provoking [0.03%]
利用生物逻辑门控马赛克策略选择性诱导铁死亡和激活STING途径实现个性化三阴性乳腺癌精准治疗
Shuai Guo,Tianwang Guan,Yushen Ke et al.
Shuai Guo et al.
Amidst the therapeutic quandaries associated with triple-negative breast cancer (TNBC), an aggressive malignancy distinguished by its immune resistance and limited treatment avenues, the urgent need for innovative solutions is underscored. ...
Targeted sonodynamic therapy induces tumor cell quasi-immunogenic ferroptosis and macrophage immunostimulatory autophagy in glioblastoma [0.03%]
靶向声动力疗法诱导胶质瘤肿瘤细胞准免疫原性铁死亡和巨噬细胞免疫刺激自噬
Meng-Fei Wang,Jie Guo,Shen-Jun Yuan et al.
Meng-Fei Wang et al.
In this study, we demonstrated the mechanism of a glioblastoma (GBM)-targeted sonodynamic therapy (SDT) strategy employing platelets loaded with a sonosensitizer based on functionalized boron nitride nanoparticles carrying chlorin e6 (BNPD-...
A size-switchable nanocluster remodels the immunosuppressive microenvironment of tumor and tumor-draining lymph nodes for improved cancer immunotherapy [0.03%]
一种尺寸可切换的纳米团簇能够重塑肿瘤及其引流淋巴结免疫抑制性微环境从而改善癌症免疫治疗效果
Qi-Song Tong,Hua Huang,Hui-Han Yu et al.
Qi-Song Tong et al.
Remodeling the immunosuppressive tumor microenvironment (TME) by immunomodulators has been well studied in the past years. However, strategies that enable concurrent modulation of both the immunosuppressive TME and tumor-draining lymph node...