Tumor vascular occlusion by calcium-based thermosensitizer provokes continuous cavitation effect and thermal energy transition efficiency of radiofrequency ablation therapy [0.03%]
钙基热敏化剂诱导肿瘤血管闭塞增强射频消融的连续空化效应和热能转换效率
Guichun Zeng,Xiayi Liang,Yuan Ling et al.
Guichun Zeng et al.
Radiofrequency ablation (RFA) therapy for hepatocellular carcinoma (HCC) suffers from incomplete ablation with tumor remnants, recurrence, and metastasis. To capture these matters, a calcium-based thermosensitizer (CBT) was constructed, whi...
Blood brain barrier-targeted delivery of double selenium nanospheres ameliorates neural ferroptosis in Alzheimer's disease [0.03%]
血脑屏障靶向双硒纳米球递送缓解阿尔茨海默病神经铁死亡
Jingyuan Wang,Zekun Wang,Yuqing Li et al.
Jingyuan Wang et al.
Alzheimer's disease (AD) as a common neurodegenerative disease showed progressive cognitive dysfunction and behavioral impairment. Currently, the deposition of amyloid β-protein (Aβ) remains the main pathomechanism. However, preventing ne...
Bovine serum albumin framed activatable NIR AIE photosensitizer for targeted tumor therapy [0.03%]
用于靶向肿瘤治疗的牛血清白蛋白封装式近红外AIE光敏剂
Kun Wu,Jiawei Liu,Xinmin Zhang et al.
Kun Wu et al.
Organic near-infrared (NIR) photosensitizers (PS) largely facilitate photodynamic therapy (PDT). To overcome aggregation induced quenching and diminishment of reactive oxygen species (ROS) generation capability of NIR-PS, aggregation-induce...
Amplifying glioblastoma immunotherapy: T cell shielding through Nitric oxide/reactive oxygen species scavenging nanoparticles Potentiates anti-PD-1 [0.03%]
通过一氧化氮/反应性氧清除纳米颗粒屏蔽胶质母细胞瘤中的T细胞以增强抗PD-1免疫疗法
Jihye Lee,Yeoul Kang,Hyori Lee et al.
Jihye Lee et al.
Despite the success of immune checkpoint blockade (ICB) therapy in various cancers, its efficacy faces challenges in glioblastoma (GBM) due to the immunosuppressive cold-tumor microenvironment. The scarcity of tumor-infiltrating T cells and...
Bone mineral density affects tumor growth by shaping microenvironmental heterogeneity [0.03%]
骨矿物质密度通过塑造微环境异质性影响肿瘤生长
Matthew A Whitman,Madhav Mantri,Emmanuel Spanos et al.
Matthew A Whitman et al.
Breast cancer bone metastasis is a major cause of mortality in patients with advanced breast cancer. Although decreased mineral density is a known risk factor for bone metastasis, the underlying mechanisms remain poorly understood because s...
Zinc sulfide nanoparticles serve as gas slow-release bioreactors for H2S therapy of ischemic stroke [0.03%]
锌硫化物纳米颗粒作为气体缓释生物反应器治疗缺血性中风中的作用
Guangqiang Li,Ruolin Zhang,Keyu Chen et al.
Guangqiang Li et al.
Stroke is one of the leading causes of death and disability in the world. Ischemic stroke causes overproduction of reactive oxygen/nitrogen species (RONS) after reperfusion, triggering inflammatory responses that further leads to cell damag...
Biomimetic non-collagenous proteins-calcium phosphate complex with superior osteogenesis via regulating macrophage IL-27 secretion [0.03%]
仿生非胶原蛋白-磷酸钙复合物通过调节巨噬细胞分泌IL-27促进成骨作用
Shenglong Tan,Xinghong Luo,Yifan Wang et al.
Shenglong Tan et al.
Traumatic defects or non-union fractures presents a substantial challenge in the fields of tissue engineering and regenerative medicine. Although synthetic calcium phosphate-based biomaterials (CaPs) such as dibasic calcium phosphate anhydr...
Nanoradiosentizers with X ray-actuatable supramolecular aptamer building units for programmable immunostimulatory T cell engagement [0.03%]
具有X射线激活的超分子适配器构件单元的纳米放射增敏剂，可编程免疫刺激T细胞参与作用
Jinming He,Xijiao Ren,Qiqi Zhang et al.
Jinming He et al.
The insufficient activation and impaired effector functions of T cells in the immunosuppressive tumor microenvironment (TME) substantially reduces the immunostimulatory effects of radiotherapy. Herein, a multifunctional nanoradiosensitizer ...
Enhanced tumor-targeting ability of transferrin-functionalized magnetic nanoparticles by in vivo AMF stimulation [0.03%]
通过体内AMF刺激增强转铁蛋白功能化磁性纳米粒子的肿瘤靶向能力
Tingbin Zhang,Jia Li,Junjie Lu et al.
Tingbin Zhang et al.
The protein corona formed on the surface of ligand-functionalized nanoparticles has been associated with the loss of targeting capability of the nanoparticles in vivo. Here, we developed a remote magnetothermal stimulation approach to regul...
Reverse magnetic resonance tuning nanoplatform with heightened sensitivity for non-invasively multiscale visualizing ferroptosis-based tumor sensitization therapy [0.03%]
一种用于非侵入性多尺度可视化铁死亡诱导肿瘤敏化治疗的灵敏度更高的反向磁共振调谐纳米平台
Yi Zhu,Jiali Deng,Hongwei Lu et al.
Yi Zhu et al.
Ferroptosis-based therapy has garnered considerable attention for its ability to kill drug-resistant cancer cells. Consequently, it holds great significance to assess the therapeutic outcomes by monitoring ferroptosis-related biomarkers, wh...