UC-MSCs based on biomimetic microniche exert excellent regulatory effects on acute brain inflammation through advantageous properties [0.03%]
基于类器官微生态位的脐带间充质干细胞在急性脑炎中的优越调节作用
Bichun Zhao,Chao Wang,Manqiang Sun et al.
Bichun Zhao et al.
Neuroinflammation triggered by activated microglia leads to neuronal damage and, to a certain extent, neurodegeneration. Human umbilical cord mesenchymal stem cells (UC-MSCs) have good immunomodulatory and neuroprotective effects as well as...
Implantation of MSC spheroid-derived 3D decellularized ECM enriched with the MSC secretome ameliorates traumatic brain injury and promotes brain repair [0.03%]
MSC球体衍生的三维脱细胞基质植入物加载间充质干细胞分泌组分可缓解创伤性脑损伤并促进脑组织修复
Grace H Chen,Kee-Chin Sia,Shao-Wen Liu et al.
Grace H Chen et al.
Traumatic brain injury (TBI) presents substantial clinical challenges, as existing treatments are unable to reverse damage or effectively promote brain tissue regeneration. Although implantable biomaterials have been proposed to support tis...
Rapid and efficient immune response induced by a designed modular cholera toxin B subunit (CTB)-based self-assembling nanoparticle [0.03%]
一种设计模块化的霍乱毒素亚单位CTB-based自组装纳米颗粒疫苗的快速和高效的免疫应答诱导能力研究
Chao Pan,Shujuan Yu,Caixia Li et al.
Chao Pan et al.
Modular self-assembling nanoparticle vaccines, represent a cutting-edge approach in immunology with the potential to revolutionize vaccine design and efficacy. Although many innovative efficient modular self-assembling nanoparticles have be...
Reprogramming metabolic microenvironment for nerve regeneration via waterborne polylactic acid-polyurethane copolymer scaffolds [0.03%]
基于水凝胶的聚乳酸-聚氨酯共聚物引导神经再生及代谢微环境重编程
Yuan Feng,Jinlin Chen,Xiao Wang et al.
Yuan Feng et al.
Cell metabolism, as the key driver of inflammation, revascularization and even subsequent tissue regeneration, is controlled by and also conversely influenced by signal transduction. Incorporation of cell metabolism into tissue engineering ...
Procoagulant, antibacterial and antioxidant high-strength porous hydrogel adhesives in situ formed via self-gelling hemostatic microsheets for emergency hemostasis and wound repair [0.03%]
一种用于紧急止血和伤口修复的自凝血微片，可形成促凝、抗菌和抗氧化高强度多孔水胶体绷带
Yingli Shan,Feng Cao,Xin Zhao et al.
Yingli Shan et al.
Procoagulant, antibacterial and analgesic hemostatic hydrogel dressing with high wet tissue adhesion, ultra-high burst pressure, and easy preparation shows huge promising for rapid hemostasis in emergencies, yet it remains a challenge. Here...
Rescue of mitochondrial dysfunction through alteration of extracellular matrix composition in barth syndrome cardiac fibroblasts [0.03%]
通过改变巴尔特综合征心脏成纤维细胞的细胞外基质成分来拯救线粒体功能障碍
Janny Piñeiro-Llanes,Silveli Suzuki-Hatano,Ananya Jain et al.
Janny Piñeiro-Llanes et al.
Fibroblast-ECM (dys)regulation is associated with a plethora of diseases. The ECM acts as a reservoir of inflammatory factors and cytokines that mediate molecular mechanisms within cardiac cell populations. The role of ECM-mitochondria cros...
Engineering M2 macrophage-derived exosomes modulate activated T cell cuproptosis to promote immune tolerance in rheumatoid arthritis [0.03%]
工程化M2型巨噬细胞来源的外泌体调控活化T细胞铜依赖性坏死促进类风湿关节炎免疫耐受形成
Guoquan Wu,Tianyu Su,Peng Zhou et al.
Guoquan Wu et al.
Nanomedicines for immune modulation have made advancements in the treatment of rheumatoid arthritis (RA). However, due to aberrations in patients' immune systems, inducing antigen-specific immune tolerance while halting disease progression ...
Bimetallic peroxide-based nanotherapeutics for immunometabolic intervention and induction of immunogenic cell death to augment cancer immunotherapy [0.03%]
用于免疫代谢干预和诱导免疫原性细胞死亡以增强癌症免疫治疗的双金属过氧化物纳米疗法
Min Han,Shiying Zhou,Zunde Liao et al.
Min Han et al.
Immunotherapy has transformed cancer treatment, but its efficacy is often limited by the immunosuppressive characteristics of the tumor microenvironment (TME), which are predominantly influenced by the metabolism of cancer cells. Among thes...
Synthetic hydrogel substrate for human induced pluripotent stem cell definitive endoderm differentiation [0.03%]
人诱导多能干细胞合成肝组织化发育的底物研究
Adriana Mulero-Russe,Ana Mora-Boza,Elijah N Marquez et al.
Adriana Mulero-Russe et al.
Human induced pluripotent stem cells (hiPSCs) can give rise to multiple lineages derived from three germ layers, endoderm, mesoderm and ectoderm. Definitive endoderm (DE) cell types and tissues have great potential for regenerative medicine...
Nanoparticle-mediated Klotho gene therapy prevents acute kidney injury to chronic kidney disease transition through regulating PPARα signaling in renal tubular epithelial cells [0.03%]
纳米颗粒介导的类脑基因治疗通过调节肾小管上皮细胞PPARα信号防止急性肾损伤转化为慢性肾病
Hongyu Li,Yuying Ouyang,Haoran Lv et al.
Hongyu Li et al.
Klotho is an anti-aging protein produced primarily by tubular epithelial cells (TECs). Down-regulated expression of Klotho in injured TECs plays a key pathogenic role in promoting acute kidney injury (AKI) to chronic kidney disease (CKD) tr...