Functional iron oxide nanoparticles cross-linked hydrogel for craniofacial bone regeneration [0.03%]
铁氧化物纳米粒子交联水凝胶颅面骨再生材料
Yanting Wu,Chenchen Zhou,Jing Xie et al.
Yanting Wu et al.
Craniofacial bone defects can be caused by accidents, diseases, heredity, and so on, which significantly affect patients' facial function and appearance. Clinical treatments, including autografts, allografts, and artificial implants, face c...
Skin-permeable FeSA-BN nanozyme for efficient transdermal inhibition and immunotherapy of melanoma [0.03%]
一种高效的黑色素瘤透皮抑制和免疫治疗铁基纳米酶
Congling Wang,Jingnan Wang,Kaiheng Zhao et al.
Congling Wang et al.
Classical Mohs surgery and chemotherapy for metastatic melanoma treatment face limitations due to low efficacy and systemic toxicity, as they do not effectively exploit the tumor's superficial nature. We propose an iron single-atom-loaded b...
Chaotropic ion-tuned protein/peptide hydrogel with enhanced trans-barrier delivery for effective periodontitis management via pathogen clearance, immunomodulation, and MSC preservation [0.03%]
一种通过清除病原体，免疫调节和保留间充质干细胞进行有效牙周炎管理的增强型跨屏障递送变性离子调节蛋白质/肽水凝胶
Rui Wang,Jianpeng Zhou,Xin Li et al.
Rui Wang et al.
Periodontitis increases the risk of tooth loss and systemic comorbidities, with anatomical challenges, particularly in narrow periodontal pockets and furcation regions, necessitating advanced drug delivery systems. The keystone pathogen, Po...
Hierarchical arming of probiotics for improved viability to synergistically alleviate ulcerative colitis [0.03%]
分层活化益生菌以协同改善溃疡性结肠炎病情的新策略
Zuwei Liu,Lei Feng,Qin Huang et al.
Zuwei Liu et al.
Oral intake of probiotics has potential benefits for alleviating ulcerative colitis (UC); however, the challenging environments (e.g., gastric acid and bile salts) in the gastrointestinal tract hinder their effectiveness. Additionally, the ...
Microalgae-MOF integrated drug delivery system for cranial radiotherapy and chemotherapy-induced brain injury [0.03%]
微藻- MOF集成的药物递送系统用于颅部放疗和化疗引起的脑损伤
Xuejiao Li,Jiahui Ye,Danni Zhong et al.
Xuejiao Li et al.
The combination of cranial radiotherapy and chemotherapy may cause brain damage and cognitive dysfunction, therefore developing protective strategies for the treatment of chemoradiotherapy-induced brain injury is of great significance. Defe...
Biomaterials innovations and challenges for wearable bioelectronic devices [0.03%]
可穿戴生物电子器件的生物材料创新与挑战
Seong-Jong Kim,Tae Yeon Kim,John A Rogers et al.
Seong-Jong Kim et al.
Targeted depletion of intratumoral bacteria using PEGylated metronidazole to augment cancer treatment efficacy [0.03%]
使用PEG修饰的甲硝唑靶向清除瘤内细菌以增强癌症治疗效果
Xijun Wang,Yiran Wang,Chang Guo et al.
Xijun Wang et al.
Since the infiltration of intratumoral microbiota is associated with aggressive phenotypes of cancer, eliminating bacteria within tumors has become an attractive approach to cancer treatment. By self-assembly of PEGylated metronidazole (MTI...
Sp1 mechanotransduction regulates breast cancer cell invasion in engineered viscoelastic extracellular matrices [0.03%]
由Sp1介导的力学信号转导调节肿瘤细胞在仿生细胞外基质中的侵袭行为
Abhishek Sharma,Rowan F Steger,Jen M Li et al.
Abhishek Sharma et al.
Breast cancer progression involves extensive remodeling of the extracellular matrix (ECM), including increased stiffness, altered viscoelasticity (stress relaxation), and elevated collagen levels. While in vitro experiments have revealed a ...
Apoptosis as a strategy for enhancing decellularization and remodeling of tissue-engineered heart valves [0.03%]
凋亡作为增强组织工程心脏瓣膜脱细胞和改建的策略
Pascal Breitenstein,Marcy Martin,Valery L Visser et al.
Pascal Breitenstein et al.
In situ tissue-engineered heart valves (TEHVs) using human cell-derived tissue engineered matrices (hTEMs) offer a promising solution to current heart valve prosthesis limitations. Decellularization is crucial for producing hTEMs by removin...
Efficacy and safety of the low-temperature-derived 3D printed biodegradable Mg-containing composite porous scaffold for bone defect repair: A prospective and multi-center randomized controlled trial [0.03%]
低温脱细胞3D打印含镁可降解多孔复合支架修复骨缺损的临床疗效与安全性：一项前瞻性多中心随机对照试验
Maoqi Gong,Yejun Zha,Shuai Lu et al.
Maoqi Gong et al.
Achieving effective bone regeneration of critical-size bone defects resulted from either trauma or metabolic disorders is a big clinical challenge. Biodegradable and bioactive bone substitutes designed for filling up bone defects to enhance...