Asymmetric-interfacial nanofibrous membranes with diode-like exudate transport for nanozyme-catalyzed antibacterial wound healing [0.03%]
用于纳米酶催化的抗菌伤口愈合的类似二极管的不对称界面纳纤膜
Xiaolong Ou,Ye Qi,Siqi Sun et al.
Xiaolong Ou et al.
Antibiotic-resistant wound infections require dressings that rapidly remove protein-rich exudate, resist fouling and bacterial adhesion, and provide drug-sparing antimicrobial activity. Here we develop asymmetric-interfacial Janus nanofibro...
Microenvironment-bionic scaffold and multi-cell spatial patterning for area-specific meniscus regeneration [0.03%]
区域特异性半月板再生的微环境仿生支架和多细胞空间模式化
Shanhong Xie,Chen Jin,Yuanqi Ma et al.
Shanhong Xie et al.
The limited regenerative capacity of injured meniscal tissue necessitates the development of advanced tissue-engineered alternatives. However, conventional homogeneous meniscal implants often fail to replicate the inherent area-specific arc...
Modeling calcific aortic valve disease with engineered human valve tissues identifies SAMHD1 as a therapeutic target [0.03%]
利用工程化的人类瓣膜组织建立主动脉瓣钙化的疾病模型并确定SAMHD1为治疗靶点
Xiangfu Meng,Qian Zhou,Zijin Zhu et al.
Xiangfu Meng et al.
Valvular heart disease (VHD) affects over 209 million people worldwide, with calcific aortic valve disease (CAVD) playing an increasingly dominant role. However, no effective pharmacotherapies are currently available. Existing animal or cel...
Cascade-catalytic microneedles convert the tumor cholesterol shield into an oxidative spear for self-amplifying ferroptosis-driven cancer immunotherapy [0.03%]
级联催化微针将肿瘤胆固醇护盾转化为氧化之矛用于铁死亡驱动的自增益癌症免疫治疗
Rongjie Yang,Yu Zhang,Yushu Dong et al.
Rongjie Yang et al.
Ferroptosis holds great promise for cancer immunotherapy, yet elevated cholesterol levels in tumor cells impose substantial structural and functional barriers to ferroptosis. Here, a cascade-catalytic nanocomposite microneedle platform (CSM...
Mitochondrial-targeted nano-enhancer driving a self-amplifying NAD+ feedback loop to reprogram MSC spheroids metabolism for accelerated bone regeneration [0.03%]
线粒体靶向纳米增强剂驱动自我放大NAD +反馈环以重新编程MSC球状体代谢并加速骨再生
Hailong Li,Xifeng Liu,Wenkai Li et al.
Hailong Li et al.
Mitochondrial oxidative phosphorylation (OXPHOS) plays a crucial role in determining the functional fate of mesenchymal stem cells (MSCs). However, effective strategies to precisely modulate mitochondrial bioenergetics within three-dimensio...
Extracellular vesicles with unique proteomic signatures from self-organized cardiac spheroids under hydrodynamic stimulation [0.03%]
流体动力刺激下心脏类器官释放的携带特异性蛋白质标志物的细胞外囊泡
J E Perez,P Joanne,L Dec et al.
J E Perez et al.
Cardiac extracellular vesicles (EVs) hold promise as cell-free therapeutics for heart repair. However, robust methods to produce scalable, functional and cardiac-specific EVs at high yield remain a limiting factor in their exploitation. Her...
Rethinking the PSMA-mediated tumor targeting of nanocarrier and potentiating co-delivery of PARP/EZH2 inhibitors for robust prostate cancer treatment [0.03%]
通过PSMA介导的纳米载体肿瘤靶向作用，重新评估PARP/EZH2抑制剂联合治疗前列腺癌的效果
Qiang Huang,Yuting Li,Yifan Bi et al.
Qiang Huang et al.
Ligand-mediated targeting of prostate-specific membrane antigen (PSMA) is a prominent strategy in prostate cancer (PCa) theranostics. However, the conventional mechanism of PSMA-targeted nanomedicines, based on passive enhanced permeability...
Biomimetic natural polysaccharide-peptide hydrogels via hierarchical co-assembly: A dynamic nanofibrous shield for active intervention of postoperative adhesions [0.03%]
仿生天然多糖-肽水凝胶的分层自组装研究：一种用于术后粘连的动态纳米纤维屏障材料
Zhaopeng Wang,Daicao Wan,Ting Ma et al.
Zhaopeng Wang et al.
Postoperative adhesions are common and serious complications following abdominal and gynecological surgery, leading to chronic pain, infertility, and intestinal obstruction, yet safe and effective clinical options remain limited. Inspired b...
Switching cell-penetrating peptides from "deliverer" to "enforcer" by hydrophobic amino acid end-tagging to combat intracellular bacterial infections [0.03%]
通过疏水氨基酸端标记细胞穿透肽使其从“递送者”转变为“执行者”以对抗胞内细菌感染
Yongjie Zhu,Mengcheng Wang,Huaxiu Qin et al.
Yongjie Zhu et al.
The presence of recalcitrant intracellular bacteria (ICB) and antimicrobial resistance poses a significant challenge to global public health. Antimicrobial peptides (AMPs) and cell-penetrating peptides (CPPs) play irreplaceable roles in com...
X-ray-triggered intratumoral photosynthesis for oxygenation-enhanced ferroptosis and radiosensitization [0.03%]
基于X射线的肿瘤内仿生光合作用增强铁死亡和放疗协同抗肿瘤作用
Jinjing Hu,Zhanlin Zhang,Duwu Liao et al.
Jinjing Hu et al.
Radiotherapy (RT), a cornerstone treatment, is fundamentally limited by tumor hypoxia-induced radioresistance and the associated need for high doses that cause severe toxicities. Herein, we developed an innovative bionanohybrid platform (Cy...