Oral renal-clearable gold supraclusters for near-infrared II urinary diagnosis of ulcerative colitis [0.03%]
口服肾清除型金超团簇用于溃疡性结肠炎近红外II尿检诊断
Bang Liu,Jinghang Li,Ming Li
Bang Liu
Fluorescence biosensing offers a promising transformative strategy for non-invasively diagnosing diseases, but its deployment for clinical urinalysis is largely hindered by the lack of fluorescent endogenous biomarkers, insufficient detecti...
In situ engineering of a self-healing drug-scaffold hydrogel to block platelet-driven postoperative metastasis [0.03%]
体内工程化制备自修复药物载体水凝胶阻止血小板介导的术后转移
MiriGuli Musa,Jianbin Shi,Yupeng Wang et al.
MiriGuli Musa et al.
Surgical resection inadvertently promotes metastasis via platelet activation and tumor cell-platelet aggregation. Conventional postoperative therapies fail to address this early pro-metastatic window and lack precise local modulation. Herei...
Zhongqing Sun,Jie Zhao,Jia Li et al.
Zhongqing Sun et al.
Ischemic stroke remains a leading cause of long-term disability worldwide, and existing therapies have a very limited capacity to repair lost neurons or restore brain function. This review examines how biomaterial-enhanced stem cell therapi...
Synergistic immunotherapy of NSCLC enabled by a biomimetic nanodelivery system for autophagy-mediated MDSC reprogramming and metabolic modulation [0.03%]
一种用于自噬介导的髓源性抑制细胞重编程和代谢调节的仿生纳米递送系统，可协同免疫治疗非小细胞肺癌
Ziqi Guo,Xianyan Liang,Haoran Ding et al.
Ziqi Guo et al.
The immunosuppressive tumor microenvironment (TME) in non-small cell lung cancer (NSCLC), particularly the dominance of myeloid-derived suppressor cells (MDSCs), remains a major barrier to effective immunotherapy. Here, we developed a bioen...
Ru/CoMn-LDH@CTP nanozymes with catalytic antioxidant activity alleviate myocardial glucolipotoxicity through inhibition of lipid peroxidation [0.03%]
具有抗氧化活性的Ru/CoMn-LDH@CTP纳米酶通过抑制脂质过氧化缓解心肌糖脂毒性
Susu Zhang,Wuming Hu,Tao Wang et al.
Susu Zhang et al.
Diabetic cardiomyopathy (DbCM), a severe complication of type 2 diabetes mellitus (T2DM), is driven by glucolipid metabolism dysregulation-induced oxidative stress and ferroptosis. Current clinical management, primarily relying on glucose-l...
Tumor microenvironment-responsive self-assembling nanotherapeutics integrating chemo-, anti-angiogenic, and immunostimulatory therapy for triple-negative breast cancer [0.03%]
一种自组装的纳米药物递送系统同时实现三阴性乳腺癌化疗、抗血管生成和免疫刺激治疗
Weihong Nie,Tongxiao Luan,Chengxun Liu et al.
Weihong Nie et al.
Triple-negative breast cancer (TNBC) remains a significant clinical challenge due to the lack of actionable targets, dose-limiting cardiotoxicity, and the limited efficacy of single-modality therapies. Doxorubicin (DOX), a first-line chemot...
Heteroleptic ruthenium(II) complexes-based sonocatalysts trigger gasdermin D palmitoylation to augment hypoxia-resistant non-canonical pyroptotic immunotherapy [0.03%]
基于杂配二价钌复合物的声催化剂可通过触发气体衍生蛋白D棕榈酰化来增强缺氧抗性非经典焦亡免疫治疗
Han Xu,Fangmian Wei,Mengjie Hou et al.
Han Xu et al.
Sonodynamic therapy is expected to induce pyroptosis of cancer cells and activate the immune response. However, its efficacy is limited by the tumor hypoxic microenvironment. Moreover, these sonosensitizers trigger a gasdermin D palmitoylat...
A metabolically reprogrammable nanoplatform potentiates photodynamic immunotherapy through glycolytic blockade [0.03%]
一种代谢可重构的纳米平台通过糖酵解阻断增强光动力免疫治疗
Jingtian Zhang,Zhaoyun Liu,Yajing Jiang et al.
Jingtian Zhang et al.
Tumor glycolysis supports malignant progression and promotes an immunosuppressive microenvironment, but glycolysis blockade alone often gives limited therapeutic benefit because tumor cells can adapt metabolically and metabolic inhibition d...
Gut-derived macrophages as endogenous carriers for brain-targeted cisplatin nanotherapy [0.03%]
肠道来源的巨噬细胞作为脑靶向顺铂纳米疗法的内源性载体
Ying Gong,Jie Yan,Yuhe Yang et al.
Ying Gong et al.
Central nervous system lymphoma (CNSL) is difficult to treat owing to the blood-brain barrier and limited efficacy of conventional chemotherapy. Herein, we report a bioinspired cisplatin-based nanomedicine that exploits gut-derived macropha...
PTGFRN- and IL-4-overexpressing exosome-functionalized Janus fibrous scaffolds for enhanced heterogeneous tissue regeneration [0.03%]
用于增强异质组织再生的PTGFRN和IL-4过表达外泌体功能化Janus纤维支架
Shue Jin,Jidong Li,Zongke Zhou et al.
Shue Jin et al.
Bone defects caused by trauma, infection, or tumor removal are often combined with soft tissue injury. This creates a major clinical problem because there are no effective methods to repair both hard and soft tissues at the same time. This ...