Dynamic changes in the structure and function of brain mural cells around chronically implanted microelectrodes [0.03%]
长期植入微电极周围脑膜细胞的结构和功能的动态变化
Steven M Wellman,Adam M Forrest,Madeline M Douglas et al.
Steven M Wellman et al.
Integration of neural interfaces with minimal tissue disruption in the brain is ideal to develop robust tools that can address essential neuroscience questions and combat neurological disorders. However, implantation of intracortical device...
A 3D-printed microdevice encapsulates vascularized islets composed of iPSC-derived β-like cells and microvascular fragments for type 1 diabetes treatment [0.03%]
一种用于治疗I型糖尿病的包含由诱导多能干细胞分化得到的类似β细胞和微血管碎片的胰岛血管组织的3D打印微型装置
Shuang Chen,Wenshuang Wang,Lanlin Shen et al.
Shuang Chen et al.
Transplantation of insulin-secreting cells provides a promising method for re-establishing the autonomous blood glucose control ability of type 1 diabetes (T1D) patients, but the low survival of the transplanted cells hinder the therapeutic...
Biodegradable stimulating electrodes for resident neural stem cell activation in vivo [0.03%]
用于体内激活 resident 神经干细胞的可降解刺激电极
Tianhao Chen,Kylie Sin Ki Lau,Aryan Singh et al.
Tianhao Chen et al.
Brain stimulation has been recognized as a clinically effective strategy for treating neurological disorders. Endogenous brain neural precursor cells (NPCs) have been shown to be electrosensitive cells that respond to electrical stimulation...
A positive-feedback loop suppresses TNBC tumour growth by remodeling tumour immune microenvironment and inducing ferroptosis [0.03%]
一个正反馈环通过重塑肿瘤免疫微环境和诱导铁死亡来抑制三阴性乳腺癌的生长
Pingting Ye,Chunhui Wang,Yixuan Wen et al.
Pingting Ye et al.
Triple-negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer due to poor immunogenicity and limited immune cell infiltration, efficient therapeutics are still deficiency. Ferroptosis, a reactive oxygen species ...
Corrigendum to "Dual-step irradiation strategy to sequentially destroy singlet oxygen-responsive polymeric micelles and boost photodynamic cancer therapy" [Biomater. 275 (2021) 120959] [0.03%]
“双步辐照策略依次破坏单线态氧响应聚合物胶束并增强光动力癌症治疗”一文的勘误[Biomater. 275 (2021) 120959]
Kai Deng,Hui Yu,Jia-Mi Li et al.
Kai Deng et al.
Published Erratum
Biomaterials. 2025 Apr:315:122952. DOI:10.1016/j.biomaterials.2024.122952 2025
Engineered VNP20009 expressing IL-15&15Rα augments anti-tumor immunity for bladder cancer treatment [0.03%]
工程化表达IL-15&15Rα的VNP20009增强抗肿瘤免疫用于膀胱癌治疗
Bo Liu,Kaiwei Wang,Qiaofeng Li et al.
Bo Liu et al.
Surgical resection combined with intravesical instillation of chemotherapeutics or Bacillus Calmette-Guerin (BCG) to remove residual cancer cells is the gold standard for the clinical treatment of patients with bladder cancer. In a recent c...
A precision intelligent nanomissile for inhibiting tumor metastasis, boosting energy deprivation and immunotherapy [0.03%]
一种用于抑制肿瘤转移、促进能量耗竭和免疫治疗的智能纳米导弹
Shan Gao,Meng Liu,Yu Zhang et al.
Shan Gao et al.
The epithelial-mesenchymal transition (EMT), tumor stroma and local metabolic alterations cooperate to establish a unique tumor microenvironment (TME) that fosters tumor progression and metastasis. To tackle this challenge, a precision inte...
Transplantation of peripheral nerve tissueoid based on a decellularized optic nerve scaffold to restore rat hindlimb sensory and movement functions [0.03%]
基于脱细胞视神经支架的外周神经组织移植恢复大鼠后肢感觉和运动功能研究
Zhao-Wei Zhu,Ge Li,Guang-Geng Wu et al.
Zhao-Wei Zhu et al.
Peripheral nerve injury (PNI) involving the loss of sensory and movement functions is challenging to repair. Although the gold standard of PNI repair is still the use of autologous nerve grafts, the destruction of the donor side is inevitab...
Visible light-induced simultaneous bioactive amorphous calcium phosphate mineralization and in situ crosslinking of coacervate-based injectable underwater adhesive hydrogels for enhanced bone regeneration [0.03%]
可见光诱导同时生物活性无定形磷酸钙矿化及原位交联胶粒基注射型水下粘附性骨再生水凝胶
Jinyoung Yun,Hyun Tack Woo,Sangmin Lee et al.
Jinyoung Yun et al.
The field of bone tissue engineering is vital due to increasing bone disorders and limitations of traditional grafts. Injectable hydrogels offer minimally invasive solutions but often lack mechanical integrity and biological functionality, ...
Aggregation-induced emission-based phototheranostics to combat bacterial infection at wound sites: A review [0.03%]
基于聚集诱导发光的抗菌感染光诊疗策略综述
Zhurun Fang,Shixuan Zhang,Wentao Wang et al.
Zhurun Fang et al.
The healing of chronic wounds infected by bacteria has attracted increasing global concerns. In the past decades, antibiotics have certainly brought hope to cure bacteria-infected chronic wounds. However, the misuse of antibiotics leads to ...