Responsive plasmonic hybrid nanorods enables metabolism reprogramming via cuproptosis-photothermal combined cancer therapy [0.03%]
响应性等离激元杂化纳米棒通过铜死亡-光热协同调节癌症代谢实现肿瘤治疗
Qian Xie,Tao Sun,Liang Zhang et al.
Qian Xie et al.
Abnormal tumor metabolism leads to tumor growth, metastasis, and recurrence, reprogramming tumor metabolism and activating potent anti-tumor immune response have been demonstrated to have good therapeutic effects on tumor elimination. Coppe...
Self-propelling intelligent nanomotor: A dual-action photothermal and starvation strategy for targeted deep tumor destruction [0.03%]
一种自推进智能纳米马达：用于精准破坏深部肿瘤的光热和饥饿双重作用策略
Ling Mei,Qihang Ding,Yuxin Xie et al.
Ling Mei et al.
Delivering nanoparticles to deep tumor tissues while maintaining high therapeutic efficacy and minimizing damage to surrounding tissues has long posed a significant challenge. To address this, we have developed innovative self-propelling bo...
Overcoming tumor hypoxic bismuth-based ternary heterojunctions enable defect modulation-augmented tumor sonocatalytic immunotherapy [0.03%]
克服肿瘤缺氧的铋基三元异质结增强缺陷调节肿瘤声催化免疫治疗
Zongyan He,Qian Wang,Jun Du et al.
Zongyan He et al.
Inducing reactive oxygen species (ROS) via sonocatalysis to initiate inflammatory programmed cell death (PANoptosis) and immunogenic cell death (ICD) presents a promising strategy for activatable cancer immunotherapy. However, the limited R...
Self-healing Ppy-hydrogel promotes diabetic skin wound healing through enhanced sterilization and macrophage orchestration triggered by NIR [0.03%]
近红外触发的自修复ppy-水凝胶通过促进消毒和巨噬细胞调控来促进糖尿病皮肤伤口愈合
Zhuangzhuang Chu,Xingdan Liu,Tong Zhao et al.
Zhuangzhuang Chu et al.
Non-healing diabetic foot ulcers are the knotty public health issue due to the uncontrolled bacterial infection, prolonged inflammation, and inferior vessel remodeling. In this work, polypyrrole (Ppy) was added into the hybrid hydrogel cont...
A NIR-II emissive sonosensitized biotuner for pyroptosis-enhanced sonodynamic therapy of hypoxic tumors [0.03%]
一种近红外二区发光声敏活化生物 tuner，用于增强焦亡型肿瘤声动力学治疗效果
Xiaoyu Wang,Weijie Chi,Jiao Wu et al.
Xiaoyu Wang et al.
Pyroptosis is considered as a new way to effectively boost the immune response of tumors and inhibit tumor growth. Effective strategies to induce pyroptosis mainly rely on chemotherapeutic drugs and phototherapy, but their potential biotoxi...
On-demand reprogramming of immunosuppressive microenvironment in tumor tissue via multi-regulation of carcinogenic microRNAs and RNAs dependent photothermal-immunotherapy using engineered gold nanoparticles for malignant tumor treatment [0.03%]
基于工程化金纳米粒子的多通路光热免疫联合治疗恶性肿瘤：致癌性microRNA和lncRNA的协同调控实现肿瘤组织内免疫抑制微环境的按需重编程
Li Chen,Wenjun Tang,Jie Liu et al.
Li Chen et al.
The frequent immune escape of tumor cells and fluctuating therapeutic efficiency vary with each individual are two critical issues for immunotherapy against malignant tumor. Herein, we fabricated an intelligent core-shell nanoparticle (SNAs...
Regulatory T cells engineered with polyphenol-functionalized immunosuppressant nanocomplexes for rebuilding periodontal hard tissue under inflammation-challenged microenvironment [0.03%]
利用茋功能化免疫抑制剂纳米复合物工程改造的调节性T细胞在炎症环境下的牙周硬组织再生中的作用
Bo Zhang,Guidong Gong,Yunxiang He et al.
Bo Zhang et al.
Global aging heightens the risk of oral disorders, among which periodontitis is the major cause of tooth loss in the aging population. The regeneration of damaged periodontal hard tissue is highly challenging due to the existence of the ref...
Emerging COX-2 inhibitors-based nanotherapeutics for cancer diagnosis and treatment [0.03%]
基于COX-2抑制剂的纳米疗法在癌症诊断和治疗中的新兴应用
Ruiping Huang,Jiang Yu,Baoyue Zhang et al.
Ruiping Huang et al.
Increasing evidence has showed that tumorigenesis is closely linked to inflammation, regulated by multiple signaling pathways. Among these, the cyclooxygenase-2/prostaglandin E2 (COX-2/PGE2) axis plays a crucial role in the progression of b...
Pulmonary delivery of dual-targeted nanoparticles improves tumor accumulation and cancer cell targeting by restricting macrophage interception in orthotopic lung tumors [0.03%]
双重靶向纳米颗粒的肺递送通过限制巨噬细胞拦截来改善原发性肺癌中的肿瘤积累和癌细胞靶向作用
Di Ge,Siqi Ma,Tingting Sun et al.
Di Ge et al.
Despite the recognized potential of inhaled nanomedicines to enhance and sustain local drug concentrations for lung cancer treatment, the influence of macrophage uptake on targeted nanoparticle delivery to and within tumors remains unclear....
Sensorable zwitterionic antibacterial hydrogel for wound electrostimulation therapy [0.03%]
用于伤口电刺激治疗的感测阳离子抗菌水凝胶
Jinghua Li,Meijun Chen,Shaowen Cheng et al.
Jinghua Li et al.
Wound healing process has always been a focal point of concern, with a plethora of hydrogel dressings available; however, their therapeutic efficacy remains a hindrance to wound closure. This article reports on a dual-network conductive sys...