Mesoporous polydopamine nanoparticle-based tolerogenic vaccine induces antigen-specific immune tolerance to prevent and treat autoimmune multiple sclerosis [0.03%]
中空多巴胺纳米粒子基耐受疫苗诱导自身抗原特异性免疫耐受防控实验性自身免疫性脑脊髓炎
Ngoc Man Phan,Thanh Loc Nguyen,Dong Kwang Min et al.
Ngoc Man Phan et al.
Multiple sclerosis (MS) is a chronic neurological disorder derived from autoreactive immune system attacking the protective myelin sheath that surrounds nerves in the central nervous system (CNS). Here, a tolerogenic nanovaccine for generat...
A sequential stimuli-responsive hydrogel promotes structural and functional recovery of severe spinal cord injury [0.03%]
一种序贯刺激响应性水凝胶可促进严重脊髓损伤的结构和功能恢复
Hu Chen,Wanshun Wang,Yiming Yang et al.
Hu Chen et al.
Utilizing drug-loaded hydrogels to restore nerve conductivity emerges as a promising strategy in the treatment of spinal cord injury (SCI). However, many of these hydrogels fail to deliver drugs on demand according to the dynamic SCI pathol...
Tailoring osteoimmunity and hemostasis using 3D-Printed nano-photocatalytic bactericidal scaffold for augmented bone regeneration [0.03%]
用于增强骨再生的3D打印纳米光催化杀菌支架以调节成骨免疫和止血响应
Sayan Deb Dutta,Jin Hexiu,Md Moniruzzaman et al.
Sayan Deb Dutta et al.
Bone hemorrhage, infection, and large bone defects following surgical treatment of traumatic bone injury have raised potential concerns, underscoring the urgent need to develop multifunctional therapeutic platforms that can effectively addr...
Corrigendum to "Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization" [Biomaterials 264 (2021) 120390] [0.03%]
关于“用于巨噬细胞凋亡和重编程的靶向银纳米颗粒治疗类风湿性关节炎”[生物材料264(2021)120390]的勘误表
Yihua Yang,Lina Guo,Zhe Wang et al.
Yihua Yang et al.
Published Erratum
Biomaterials. 2025 May:316:122994. DOI:10.1016/j.biomaterials.2024.122994 2025
Antigen self-presenting dendrosomes swallowing nanovaccines boost antigens and STING agonists codelivery for cancer immunotherapy [0.03%]
用于癌症免疫治疗的自呈抗原树状体吞吐纳疫苗以增强抗原和STING激动剂的共递送
Jiaxuan Xia,Xing Chen,Meichen Dong et al.
Jiaxuan Xia et al.
Cancer vaccines show promise by eliciting tumor-specific cytotoxic T lymphocytes (CTL) responses. Efficient cytosolic co-delivery of antigens and adjuvants to dendritic cells (DCs) is crucial for vaccines to induce anti-tumor immunity. Howe...
Bioactive phosphorus dendrimers deliver protein/drug to tackle osteoarthritis via cooperative macrophage reprogramming [0.03%]
生物活性磷树枝状分子通过协同巨噬细胞重编程递送蛋白/药物治疗骨关节炎
Huxiao Sun,Mengsi Zhan,Yu Zou et al.
Huxiao Sun et al.
Reprogramming imbalanced synovial macrophages and shaping an immune microenvironment conducive to bone and cartilage growth is crucial for efficient tackling of osteoarthritis (OA). Herein, we present a co-delivery nanosystem based on gener...
Gene-engineered polypeptide hydrogels with on-demand oxygenation and ECM-cell interaction mimicry for diabetic wound healing [0.03%]
具有按需供氧和细胞外基质细胞相互作用模拟的基因工程多肽水凝胶用于糖尿病伤口修复
Xiao-Ting Xie,Cheng-Hao Gao,Lin-Fang Tan et al.
Xiao-Ting Xie et al.
The treatment of infected diabetic wounds remains a significant clinical challenge due to pathogen infection, excessive inflammation, and impaired angiogenesis with troubled extracellular matrix (ECM) - cell and cell - cell interaction. Her...
Fabrication of a transforming growth factor β1 functionalized silk sericin hydrogel through genetical engineering to repair alveolar bone defects in rabbit [0.03%]
通过基因工程制备TGF-β1功能化丝素蛋白水凝胶修复兔牙槽骨缺损
Feng Wang,Anfeng Ning,Xuecheng Sun et al.
Feng Wang et al.
Cleft palate is one of the most prevalent congenital craniofacial birth defects in human congenital facial anomaly. Severe cleft palate is usually accompanied by alveolar bone defects (ABDs). Growth factors (GFs) are considered as desirable...
A super soft thermoplastic biodegradable elastomer with high elasticity for arterial regeneration [0.03%]
一种超软可热塑性生物降解弹性体用于动脉再生具有高弹性和优异的加工性能
Yating Jia,Xin Xu,Hao Lu et al.
Yating Jia et al.
Elastomers with innovative performance will provide new opportunities for solving problems in soft tissue repair, such as arterial regeneration. Herein, we present a thermoplastic biodegradable elastomer (PPS) that differs from the rigid, l...
Drug-device-field integration for mitochondria-targeting dysfunction and tumor therapy by home-tailored pyroelectric nanocomposites [0.03%]
用于线粒体靶向功能障碍和肿瘤治疗的药物-设备-场一体化的热电纳米复合材料疗法
Zhe Liu,Yanxi Yang,Xinru Kong et al.
Zhe Liu et al.
In spite of the hypoxia tumor microenvironment, an efficacious treatment with minimal invasiveness is highly desirable. Among common cellular organelles, mitochondria is a common target for inductive cellular apoptosis and tumor proliferati...