Cationic conjugated polymers with tunable hydrophobicity for efficient treatment of multidrug-resistant wound biofilm infections [0.03%]
具有可调亲水性的阳离子导电聚合物有效治疗耐多药生物膜伤口感染
Ahmed Nabawy,Aritra Nath Chattopadhyay,Jessa Marie V Makabenta et al.
Ahmed Nabawy et al.
Biofilm-associated infections arising from antibiotic-resistant bacteria pose a critical challenge to global health. We report the generation of a library of cationic conjugated poly(phenylene ethynylene) (PPE) polymers featuring trimethyla...
Molecular imaging-guided diagnosis and treatment integration for brain diseases [0.03%]
分子影像引导的脑疾病的诊断与治疗一体化模式
Donghu Yu,Menghao Liu,Qihang Ding et al.
Donghu Yu et al.
In practical clinical scenarios, improved diagnostic methods have been developed for the precise visualization of molecular targets using molecular imaging in brain diseases. Recently, the introduction of innovative molecular imaging modali...
Advancements of ROS-based biomaterials for sensorineural hearing loss therapy [0.03%]
基于ROS的生物材料在神经感觉性听力损失治疗中的进展
Baoying Xu,Yuqi Huang,Dehong Yu et al.
Baoying Xu et al.
Sensorineural hearing loss (SNHL) represents a substantial global health challenge, primarily driven by oxidative stress-induced damage within the auditory system. Excessive reactive oxygen species (ROS) play a pivotal role in this patholog...
Advanced oral breviscapine sustained-release tablets for improved ischemic stroke treatment [0.03%]
advanced oral breviscapine缓释片治疗缺血性卒中的研究
Tingting Hao,Guangwei Jiang,Chenteng Lin et al.
Tingting Hao et al.
This study aimed to address the challenges associated with the low oral bioavailability and the necessity for frequent dosing of breviscapine (BRE), a mainstream drug in the treatment of cardiovascular and cerebrovascular diseases. The poor...
A nucleoside-based supramolecular hydrogel integrating localized self-delivery and immunomodulation for periodontitis treatment [0.03%]
一种用于牙周炎治疗的基于核苷的超分子水凝胶，集局部自递送和免疫调节于一体
Fangyuan Shuai,Yijia Yin,Yufei Yao et al.
Fangyuan Shuai et al.
Periodontitis is a highly prevalent oral disease characterized by bacterial-induced hyperactivation of the host immune system, leading to a sustained inflammatory response and osteoclastic activity, which ultimately results in periodontal d...
Hijacking endogenous iron to amplify lysosomal-mitochondrial cascade damage for boosting anti-tumor immunotherapy [0.03%]
劫持内源铁以放大溶酶体-线粒体级联损伤从而增强抗肿瘤免疫治疗
Hanghang Liu,Menglong Hua,Yaobao Han et al.
Hanghang Liu et al.
The cross-talk between lysosomes and mitochondria is crucial for keeping intracellular homeostasis and metabolic function, providing a promising approach for tumor therapy. Herein, we employed polyvinylpyrrolidone (PVP)-modified Cu-gallic a...
Macrophage-hitchhiked, effervescence-induced nanoemulsions for enhanced oral chemotherapy and immunotherapy: Impact on absorption route [0.03%]
利用巨噬细胞输运的发酵诱导纳米乳剂增强口服化疗和免疫疗法：对吸收途径的影响
Nhien Nguyen,Tuyet-Mai Hoang,Tun-Yu Huang et al.
Nhien Nguyen et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer. Paclitaxel (PTX), typically administered intravenously (IV) as chemotherapy, shows promise for triggering immunogenic cell death (ICD) and may serve as a potential immunothe...
Radiotherapy-immunomodulated nanoplatform triggers both hypoxic and normoxic tumor associated antigens generation for robust abscopal effect and sustained immune memory [0.03%]
放射免疫调节纳米平台触发缺氧和常氧肿瘤抗原的生成，以获得有力的远隔效应和持久的免疫记忆
Jie Li,Chenfeng Tan,Jin Yang et al.
Jie Li et al.
Radiotherapy (RT) induced abscopal effect has garnered substantial attention, nevertheless, it is rarely observed in clinics, due to the tumor hypoxia-related radioresistance, inadequate immune stimulation, and immunosuppressive tumor micro...
Amplifying Ca2+ overload by engineered biomaterials for synergistic cancer therapy [0.03%]
通过工程化生物材料放大Ca2+过载以协同治疗癌症
Jun-Long Liang,Yangyang Cao,Kaiwei Lv et al.
Jun-Long Liang et al.
Ca2+ overload is one of the most widely causes of inducing apoptosis, pyroptosis, immunogenic cell death, autophagy, paraptosis, necroptosis, and calcification of tumor cells, and has become the most valuable therapeutic strategy in the fie...
Lighthouses illuminating tumor metastasis: The application of fluorescent probes in the localization and imaging metastatic lymph nodes across various tumors [0.03%]
探照肿瘤转移的灯塔：荧光探针在各种肿瘤转移淋巴结定位和成像中的应用
Qi Dang,Linhao Zhang,Huipeng Ma et al.
Qi Dang et al.
The significance of metastatic lymph nodes in tumor diagnosis and prognosis is self-evident. With the deepening of research on the lymphatic system and the advancement of imaging technology, an increasing number of near-infrared fluorescent...