A cationic main-chain poly(carbonate-imidazolium) potent against Mycobacterium abscessus and other resistant bacteria in mice [0.03%]
一种针对小鼠中嗜血毛孢子菌和其他耐药细菌的阳离子主链聚(碳酸酯-咪唑
Zhangyong Si,Yan Sun,Chongyun Tan et al.
Zhangyong Si et al.
The incidence of serious lung infections due to Mycobacterium abscessus, a worrying non-tuberculosis mycobacteria (NTM) species, is rising and has in some countries surpassed tuberculosis. NTM are ubiquitous in the environment and can cause...
Regulating tumor cells to awaken T cell antitumor function and enhance melanoma immunotherapy [0.03%]
调控肿瘤细胞唤醒T细胞抗肿瘤功能并增强黑色素瘤免疫治疗效果
Weihan Zhang,Shijun Yuan,Zipeng Zhang et al.
Weihan Zhang et al.
Tumor cells transmit various immunosuppressive signals and induce a dysfunctional state in T cells, which essentially leads to immune escape and tumor progression. However, developing effective strategies to counteract the domestication of ...
X-ray-activated nanoscintillators integrated with tumor-associated neutrophils polarization for improved radiotherapy in metastatic colorectal cancer [0.03%]
一种基于X射线激活的与肿瘤相关中性粒细胞极化相结合的纳米闪烁体用于改善转移性结直肠癌的放射治疗
Hui Li,Junyi Zeng,Qing You et al.
Hui Li et al.
Radiotherapy, employing high-energy rays to precisely target and eradicate tumor cells, plays a pivotal role in the treatment of various malignancies. Despite its therapeutic potential, the effectiveness of radiotherapy is hindered by the t...
Interfacial engineering for biomolecule immobilisation in microfluidic devices [0.03%]
微流控装置界面工程在生物分子固定的應用
Deepu Ashok,Jasneil Singh,Henry Robert Howard et al.
Deepu Ashok et al.
Microfluidic devices are used for various applications in biology and medicine. From on-chip modelling of human organs for drug screening and fast and straightforward point-of-care (POC) detection of diseases to sensitive biochemical analys...
Selenium promotes neural development through the regulation of GPX4 and SEPP1 in an iPSC-derived neuronal model [0.03%]
硒通过诱导神经祖细胞中GPX4和SEPP1的表达来促进神经元分化成熟：一种基于人诱导多能干细胞的神经发育模型研究
Zhenzhu Dai,Yanzi Yu,Ruhai Chen et al.
Zhenzhu Dai et al.
Selenium (Se) is incorporated into selenoproteins in the form of selenocysteine, which has biological functions associated with neural development. Unfortunately, the specific roles and mechanisms of selenoproteins at different stages of ne...
Vanadium single-atoms coordinated artificial peroxidases as biocatalyst-linked immunosorbent assay for highly-sensitive carcinoembryonic antigen immunoassay [0.03%]
用于高灵敏度癌胚抗原免疫测定的钒单原子人工过氧化物酶生物催化免疫测定法
Minjia Yuan,Rui Yan,Zhenyang Zhao et al.
Minjia Yuan et al.
In medical and biomedical fields, enzyme-mimetic nanomaterials have garnered significant interest as efficacious signal enhancers for biocatalyst-linked immunosorbent assays (BLISA). Despite the burgeoning enthusiasm, engineering artificial...
Nhan Dai Thien Tram,Jian Xu,Kiat Hwa Chan et al.
Nhan Dai Thien Tram et al.
In Nature, bacterial clustering by host-released peptides or nucleic acids is an evolutionarily conserved immune defense strategy employed to prevent adhesion of pathogenic microbes, which is prerequisite for most infections. Synthetic anti...
Mitochondria-targeting materials and therapies for regenerative engineering [0.03%]
线粒体靶向材料和疗法在再生工程中的应用研究进展
Hongying Fu,Jingrong Cheng,Le Hu et al.
Hongying Fu et al.
The hemostatic, inflammatory, proliferative, and remodeling phases of healing require precise spatiotemporal coordination and orchestration of numerous biological processes. As the primary energy generators in the cell, mitochondria play mu...
A bioprinted and scalable model of human tubulo-interstitial kidney fibrosis [0.03%]
一种可生物打印和扩展的人类肾小管间质纤维化模型
Daphne Bouwens,Nazanin Kabgani,Cédric Bergerbit et al.
Daphne Bouwens et al.
Chronic kidney disease (CKD) affects more than 10% of the global population. As kidney function negatively correlates with the presence of interstitial fibrosis, the development of new anti-fibrotic therapies holds promise to stabilize func...
PPS-TLR7/8 agonist nanoparticles equip robust anticancer immunity by selectively prolonged activation of dendritic cells [0.03%]
TLR7/8激动剂纳米颗粒通过选择性延长树突状细胞的活化来装备强大的抗癌免疫能力
Yingxi Zhang,Yicheng Li,Zhaochu Xu et al.
Yingxi Zhang et al.
Checkpoint inhibitor therapies do not benefit all patients, and adjuvants play a critical role in boosting immune responses for effective cancer immunotherapy. However, their systemic toxicity and suboptimal activation kinetics pose signifi...