Targeted LNPs deliver IL-15 superagonists mRNA for precision cancer therapy [0.03%]
靶向LNP递送IL-15超级激动剂mRNA用于精准癌症治疗
Juntao Yu,Qian Li,Chaoting Zhang et al.
Juntao Yu et al.
Interleukin-15 (IL-15) emerges as a promising immunotherapeutic candidate, but the therapeutic utility remains concern due to the unexpected systematic stress. Here, we propose that the mRNA lipid nanoparticle (mRNA-LNP) system can balance ...
Hybrid membrane based biomimetic nanodrug with high-efficient melanoma-homing and NIR-II laser-amplified peroxynitrite boost properties for enhancing antitumor therapy via effective immunoactivation [0.03%]
一种基于仿生纳米药物的混合膜，具有高效的黑色素瘤同源性和近红外II激光增强型过氧亚硝酸盐助推性能，可通过有效的免疫激活来增强抗肿瘤疗法
Qi Lin,Yu Zhang,Yina Zeng et al.
Qi Lin et al.
Owing to the excellent stability, anticancer activity and immunogenicity, peroxynitrite (ONOO-) has been gained enormous interests in cancer therapy. Nevertheless, precise delivery and control release of ONOO- in tumors remains a big challe...
Phycocyanin-based multifunctional microspheres for treatment of infected radiation-induced skin injury [0.03%]
基于藻蓝蛋白的多功能微球在放射性皮炎感染治疗中的应用研究
Jia Dong,Yutong Lang,Jian He et al.
Jia Dong et al.
Radiation therapy is a primary modality for cancer treatment; however, it often leads to various degrees of skin injuries, ranging from mild rashes to severe ulcerations, for which no effective treatments are currently available. In this st...
A multifunctional mitochondria-protective gene delivery platform promote intervertebral disc regeneration [0.03%]
一种多功能线粒体保护型基因传递平台促进椎间盘再生
Yu Wang,Mingyan Deng,Ye Wu et al.
Yu Wang et al.
Intervertebral disc degeneration (IDD) is a deleterious condition driven by localized inflammation and the associated disruption of the normal homeostatic balance between anabolism and catabolism, contributing to progressive functional abno...
Janus PEGylated CuS-engineered Lactobacillus casei combats biofilm infections via metabolic interference and innate immunomodulation [0.03%]
Janus PEG修饰的工程化铜绿假单胞菌生物被膜感染干预及固有免疫调节的植物乳杆菌
Lingtong Kong,Xianli Hu,Demeng Xia et al.
Lingtong Kong et al.
Bacterial implant-associated infections predominantly contribute to the failure of prosthesis implantation. The local biofilm microenvironment (BME), characterized by its hyperacidic condition and high hydrogen peroxide (H2O2) level, inhibi...
Black phosphorus nanosheets activate tumor immunity of glioblastoma by modulating the expression of the immunosuppressive molecule PD-L1 [0.03%]
黑磷活化胶质母细胞瘤的肿瘤免疫以调控免疫抑制分子PD-L1的表达
Yue Xiong,Chao He,Junyang Qi et al.
Yue Xiong et al.
The tumor microenvironment in glioblastoma (GBM) is characterized by a pronounced immunosuppressive state, which significantly hampers tumor treatment and contributes to treatment resistance. While our previous research established that bla...
Surface-functionalized bacteria: Frontier explorations in next-generation live biotherapeutics [0.03%]
用于下一代活生物疗法的表面功能细菌：前沿探索
Jia-Ni Jiang,Fan-Hui Kong,Qi Lei et al.
Jia-Ni Jiang et al.
Screening robust living bacteria to produce living biotherapeutic products (LBPs) represents a burgeoning research field in biomedical applications. Despite their natural abilities to colonize bio-interfaces and proliferate, harnessing bact...
Effects of cell shape and nucleus shape on epithelial-mesenchymal transition revealed using chimeric micropatterns [0.03%]
基于嵌合微图案的上皮-间质转化的细胞及核形状的影响研究
Hongyu Wang,Ruili Liu,Yue Yu et al.
Hongyu Wang et al.
Epithelial-mesenchymal transition (EMT) is a key phenotypic switch in cancer metastasis, leading to fatal consequences for patients. Under geometric constraints, the morphology of cancer cells changes in both cellular and subcellular levels...
Injectable bioresponsive bone adhesive hydrogels inhibit NLRP3 inflammasome on demand to accelerate diabetic fracture healing [0.03%]
可注射生物响应性骨粘合水凝胶按需抑制NLRP3炎性小体以加速糖尿病骨折愈合
Xudan Xing,Zunlei Gong,Chuke Chen et al.
Xudan Xing et al.
Diabetes is associated with excessive inflammation, which negatively impacts the fracture healing process and delays bone repair. Previously, growing evidence indicated that activation of the nod-like receptor (NLR) family, such as nod-like...
Tertiary amine modification enables triterpene nanoparticles to target the mitochondria and treat glioblastoma via pyroptosis induction [0.03%]
叔胺修饰使三萜纳米颗粒能够靶向线粒体并通过诱导细胞焦亡治疗胶质母细胞瘤
Xingchun Gao,Xiangjun Tang,Zewei Tu et al.
Xingchun Gao et al.
Glioblastoma (GBM), the most common primary brain tumor, lacks effective treatments. Emerging evidence suggests mitochondria as a promising therapeutic target, albeit successfully targeting represents a major challenge. Recently, we discove...