A biosilica nanocage-based injectable hydrogel to trap endogenous TGF-β1 for in-situ hyaline cartilage regeneration [0.03%]
一种用于原位生成透明软骨的生物硅纳米笼载TGF-β1可注射水凝胶体系
Xiaoyu Yin,Xiao Feng,Guangkai An et al.
Xiaoyu Yin et al.
Regeneration of hyaline cartilage remains a major clinical challenge. Current first-line treatments for focal articular cartilage defects, typically induce fibrocartilage instead of hyaline cartilage, resulting in inferior mechanical and bi...
A remove-remodel-repair strategy enabled by a spatiotemporally controlled hydrogel for integrative osteosarcoma therapy [0.03%]
一种由时空可控水凝胶介导的去除-重塑-修复策略用于整合型骨肉瘤治疗
Tinglin Zhang,Yu Wang,Meigui Li et al.
Tinglin Zhang et al.
Postoperative management of osteosarcoma faces challenges such as tumor recurrence, bone defects, and infections due to the inability of conventional therapies to eradicate tumors and regenerate bone simultaneously. We developed a multifunc...
Synthetic polypeptide adjuvant-antibiotic combination eradicates polymicrobial assemblies, dormant bacteria and bacterial biofilm [0.03%]
合成多肽佐剂-抗生素组合能够清除聚微生物菌落、休眠细菌和生物膜中的细菌
Swagatam Barman,Md Waliullah Hossain,Aiswarya Chandrasseril Bansidhar et al.
Swagatam Barman et al.
In this work, we explore the potency of poly(D-peptide) (D-PP) in combination with diverse classes of antibiotics to address multidrug-resistant (MDR) Gram-negative superbugs, including their mature biofilms, polymicrobial assemblies, and d...
Ultrasmall nanosonocatalyst induces PANoptosis to suppress ovarian cancer: From patient-derived organoids to in vivo models [0.03%]
超小型纳米声催化剂诱导PANoptosis抑制卵巢癌：从患者来源的类器官到体内模型
Lingfang Xia,Chenyue Yuan,Yanqiu Duan et al.
Lingfang Xia et al.
Ovarian cancer represents one of the most lethal gynecological malignancies, marked by a high recurrence rate and dismal prognosis. Existing targeted treatments face challenges such as limited applicability, modest effectiveness, and consid...
Supramolecular nanogel aggregate as injectable regulatory barrier for preventing postoperative adhesion in diabetic colonic anastomosis [0.03%]
超分子纳米凝胶聚合物作为可注射屏障以防止糖尿病结肠吻合术后粘连形成
Huan Yu,Qing Yang,Chunhui Li et al.
Huan Yu et al.
Postoperative tissue adhesions, especially after intestinal surgeries like colonic anastomosis, frequently cause serious complications such as intestinal obstruction and chronic pain, which are worsened in diabetic conditions. Although barr...
Visible-light-responsive cationized photodynamic nanoparticles integrated with a silk fibroin-based nanofibrous matrix for enhanced ROS utilization in infected wound healing [0.03%]
一种用于感染伤口治疗的可见光响应阳离子化光动力纳米粒子与家蚕丝蛋白基纳米纤维素复合材料结合以增强ROS利用性能的研究
Hongyu Lin,Qingyan Peng,Ying Lin et al.
Hongyu Lin et al.
Drug-resistant bacteria infecting wounds and impeding their healing have become a pressing clinical challenge. Antimicrobial photodynamic therapy (aPDT) does not pose a risk of bacterial resistance, but its application is limited due to the...
Bioelectronic hydrogel driven by perovskite solar cells promotes healing of drug-resistant bacteria-infected wounds [0.03%]
基于钙钛矿太阳能电池的生物电子水凝胶促进耐药细菌感染伤口愈合
Lian Duan,Yufan Bu,Peng Zhou et al.
Lian Duan et al.
Self-powered dressings based on triboelectric or piezoelectric systems generate alternating electric stimulation (ES) that induces M1-type macrophage polarization and exacerbates inflammation, limiting therapeutic efficacy. Here, we report ...
Spatially programmed hydrogel dressing enables phase-matched sequential ion release for accelerated severe burn repair [0.03%]
空间编程水凝胶敷料实现相匹配的离子序贯释放以加速重度烧伤修复
Jibo Diao,Guangming Zhao,Mingyang Yu et al.
Jibo Diao et al.
Severe burn wounds with excessive exudation and high infection risk disrupt all four healing phases, requiring antibacterial, exudate-managing, and phase-specific strategies to drive wound contraction and tissue regeneration. Herein, we dev...
Ultrasound-gated nanobubbles for sequential pyroptosis blockade and mechanotransductive neurorepair in sepsis-associated encephalopathy [0.03%]
用于败血症相关脑病的超声波门控纳米气泡顺序阻断pyroptosis和神经转化修复疗法
Xiao Wang,Yang Liu,Mingxi Li et al.
Xiao Wang et al.
Sepsis-associated encephalopathy (SAE) is a life-threatening neuroinflammatory complication of sepsis for which effective treatment remains unavailable. A major challenge is that most therapeutics cannot efficiently cross the blood-brain ba...
Pathology-driven catalytic nanozyme-integrated adhesive hydrogel disrupts the hyperglycemia-ROS-hypoxia loop to accelerate vascularized fracture healing in diabetes [0.03%]
病理学驱动的催化纳米酶粘附水凝胶打断高血糖-活性氧-低氧环以加速糖尿病骨折愈合中的血管生成
Yu Cai,Haifeng Liang,Tianhua Xiao et al.
Yu Cai et al.
Diabetes mellitus severely impair fracture healing due to a pathological microenvironment characterized by persistent hyperglycemia, excessive reactive oxygen species (ROS), tissue hypoxia, and chronic inflammation, which together suppress ...