A radially aligned nanofiber scaffold with engineered guidance gradients for directed cell migration and accelerated wound healing [0.03%]
一种工程化梯度导向的径向排列纳米纤维支架促进细胞定向迁移和伤口加速愈合
Xindan Zhang,Ruinan Hao,Jianfeng Tong et al.
Xindan Zhang et al.
Severe skin injuries require scaffolds capable of dynamically regulating cell migration and proliferation to accelerate wound closure and tissue regeneration. However, most existing strategies rely on a single mode of guidance and fail to r...
Peptide coacervate-Prussian blue hybrid supraparticle-tailored scaffolds for revitalizing diabetic heart valve regeneration via multiplex oxidative stress regulation [0.03%]
一种肽共聚物普鲁士蓝混合超颗粒支架用于通过多模式氧化应激调节活化糖尿病人心瓣再生
Yang Fan,Du Xingzhuang,Zhao Zhiyu et al.
Yang Fan et al.
Diabetes mellitus impairs the regenerative capacity of valvular patients and poses a major barrier to successful reconstruction of autologous heart valves via in situ tissue-engineered heart valves (TEHVs). Herein, we developed a TEHV scaff...
Biofabrication and in vivo evaluation of a hybrid osteochondral implant consisting of structurally organised engineered cartilage on a 3D-printed metal scaffold [0.03%]
由结构化工程软骨组织与3D打印金属支架结合组成的软骨下骨缺损修复型植入物的制备及体内评价
Marcin Kotlarz,Conor O&#x;Keeffe,Gabriela S Kronemberger et al.
Marcin Kotlarz et al.
Restoration of the osteochondral unit presents a substantial challenge due to the complex functional demands placed on cartilage and underlying subchondral bone, with each region requiring tailored approaches to ensure successful repair. Th...
In situ genetically engineering nanosystem for reversing immunosuppression of cancer-associated fibroblasts in breast cancer radiotherapy [0.03%]
乳腺癌放射治疗中就地基因工程纳米系统逆转癌症相关成纤维细胞免疫抑制作用
Ziwen Qiu,Zhenming Lu,Yingtao Zhong et al.
Ziwen Qiu et al.
Adjuvant radiotherapy (RT) for breast cancer can activate cancer-associated fibroblasts (CAFs), leading to reduced efficacy of immunotherapy and even tumor recurrence. Pathological analysis of breast cancer reveals that the PD-L2 upregulati...
Harnessing decellularized amniotic membrane properties for ureteral repair: A fibromodulin-driven approach [0.03%]
利用脱细胞胎盘膜的性质进行输尿管修复的一种方法学：以纤维调素为核心的方法学研究
Baiyang Song,Li Fang,Yiwei Hu et al.
Baiyang Song et al.
Ureteral reconstruction remains a significant challenge due to the risk of fibrosis and insufficient epithelial regeneration, leading to suboptimal outcomes with current surgical techniques. To address these issues, a tubular porous scaffol...
A TNBC-targeting nano-radiosensitizer reverses radioresistance by synergizing GSH scavenging with dual inhibition of Trop2 and lncRNA MNX1-AS1 [0.03%]
一种针对三阴性乳腺癌的靶向纳米放敏剂通过协同清除谷胱甘肽和双重抑制Trop2及长链非编码RNA MNX1-AS1逆转放射耐药性
Zhiwei Yang,Bianfei Shao,Danni Wang et al.
Zhiwei Yang et al.
Radioresistance in triple-negative breast cancer (TNBC) frequently results in local recurrence and distant metastasis, seriously affecting the prognosis of patients. The increased generation of cellular glutathione (GSH) and the upregulatio...
A high frequency ultrasound-based platform to non-destructively quantify geometric, acoustic and mechanical properties of thin, engineered soft connective tissues in vitro [0.03%]
一种高频超声波平台 不破坏地量化薄型工程软连接组织的几何、声学和机械属性
Edwin Wong,Katya A D&#x;Costa,Eric M Strohm et al.
Edwin Wong et al.
Assessment of temporal changes in the functional properties of in vitro tissue engineered (TE) constructs is typically done by destructive endpoint analysis, which increases experimental resources, analysis time, and financial burden. To ov...
Co-delivery of CO/H2 gases for synergistic radiosensitization and intestinal protection in peritoneal metastases therapy [0.03%]
协同放射增敏和肠道保护的共输送二氧化碳/氢气气体在腹膜转移瘤治疗中的应用研究
Junna Lu,Yidan Zhang,Xin Zhao et al.
Junna Lu et al.
The combination of radiosensitizing carbon monoxide (CO) and radioprotective hydrogen (H2) holds significant potential in whole abdominal radiotherapy for the treatment of peritoneal metastases of colon cancer. However, the concurrent and c...
Cationic lipid-modified PEG-PLGA nanoparticles facilitate effective dendritic cell reprogramming to alleviate T cell-mediated autoimmunity in EAE [0.03%]
阳离子脂质修饰的PEG-PLGA纳米颗粒可促进有效重编程小胶质细胞缓解自身免疫病EAE中的T细胞介导的自身免疫反应
He Li,Xiuxiu Cong,Huizhu Tan et al.
He Li et al.
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by aberrant T cell responses and central nervous system inflammation. Dendritic cells (DCs), as key regulators of T cell activation and differentiation, represent a prom...
Antioxidase-mimetic artificial biotubes for anti-inflammatory healing and regeneration of vascular injury [0.03%]
用于血管损伤的抗炎修复和再生的类抗氧化酶人工生物管
Guliyaer Aini,Jianmei Ren,Haojie Xu et al.
Guliyaer Aini et al.
Inflammation is a major obstacle to endothelialization, which is essential to the long-term functionality of cardiovascular implants. Developing efficient antioxidant and inflammation-modulating biotubes for endothelial repair with minimal ...