Biomimetic nanostructural materials based on placental amniotic membrane-derived nanofibers for self-healing and anti-adhesion during cesarean section [0.03%]
基于胎盘绒毛膜衍生的纳米纤维的仿生纳米结构材料在剖宫产手术中的自我修复和防粘连研究
Honglei Zhu,Fenghua Liu,Yuru Liao et al.
Honglei Zhu et al.
Cesarean section (CS) is highly prevalent surgery among females. However, current absorbable anti-adhesion membranes used clinically can partially prevent postoperative adhesions but show limited efficacy in tissue regeneration, leaving pos...
Systemically administered platelet-inspired nanoparticles to reduce inflammation surrounding intracortical microelectrodes [0.03%]
基于血小板的纳米颗粒用于减少颅内微电极周围炎症
Longshun Li,Dhariyat M Menendez-Lustri,Aniya Hartzler et al.
Longshun Li et al.
Intracortical microelectrodes (IMEs) are essential for neural signal acquisition in neuroscience and brain-machine interface (BMI) systems, aiding patients with neurological disorders, paralysis, and amputations. However, IMEs often fail to...
Artificially tagging tumors with nano-aluminum adjuvant-tethered antigen mRNA recruits and activates antigen-specific cytotoxic T cells for enhanced cancer immunotherapy [0.03%]
纳米铝佐剂 tethered 抗原mRNA人工标记肿瘤细胞招募和激活抗原特异性CTL细胞增强癌症免疫治疗
Lingxiao Zhang,Jie Bai,Aining Shen et al.
Lingxiao Zhang et al.
T cell therapy for solid tumors faces significant challenges due to the immune off-target attack caused by the loss of tumor surface antigens and inactivation in acidic tumor microenvironment (TME). Herein, we developed a bifunctional immun...
Nanomedicine-unlocked radiofrequency dynamic therapy dampens incomplete radiofrequency ablation-arised immunosuppression to suppress cancer relapse [0.03%]
纳米医学解锁射频动态疗法缓解不完全射频消融引发的免疫抑制以控制癌症复发
Yan Fang,Feixiang Hu,Weiwei Ren et al.
Yan Fang et al.
Incomplete radiofrequency ablation (iRFA) not only leaves residual tumor, but also render the residual tumor highly self-adaptable and immunosuppressive, consequently expediting residual tumor progression including relapse. To address it, r...
Engineered cell membrane vesicles loaded with lysosomophilic drug for acute myeloid leukemia therapy via organ-cell-organelle cascade-targeting [0.03%]
一种通过器官-细胞-细胞器三级靶向治疗急性髓系白血病的工程化细胞膜囊泡递药系统
Fangfang Jin,Xingyu Wei,Yongcan Liu et al.
Fangfang Jin et al.
Acute myeloid leukemia (AML) presents significant treatment challenges due to the severe toxicities and limited efficacy of conventional therapies, highlighting the urgency for innovative approaches. Organelle-targeting therapies offer a pr...
Bimetallic nanoreactor mediates cascade amplification of oxidative stress for complementary chemodynamic-immunotherapy of tumor [0.03%]
双金属纳米反应器介导氧化应激级联放大用于肿瘤协同化学动力免疫治疗
Hao Zhou,Peng Bao,Yan-Tong Lin et al.
Hao Zhou et al.
As a promising tumor treatment, chemodynamic therapy (CDT) can specifically catalyze H2O2 into the cytotoxic hydroxyl radical (·OH) via Fenton/Fenton-like reaction. However, the limited H2O2 and weakly acidic pH in tumor microenvironment (...
Electroactive membranes enhance in-situ alveolar ridge preservation via spatiotemporal electrical modulation of cell motility [0.03%]
时空电学调控细胞运动性可增强电活性膜的原位牙槽嵴保存效果
Yanlan Wang,Shiqi Zhou,Xiaoshuang Wang et al.
Yanlan Wang et al.
Post-extraction alveolar bone resorption invariably compromises implant placement and aesthetic restoration outcomes. Current non-resorbable membranes exhibit limited efficacy in alveolar ridge preservation (ARP) due to insufficient cell re...
Targeting m6A demethylase FTO to heal diabetic wounds with ROS-scavenging nanocolloidal hydrogels [0.03%]
靶向m6A去甲基化酶FTO的ROS清除纳米胶体水凝胶促进糖尿病伤口愈合
Xinyao Zheng,Shaohui Deng,Yuan Li et al.
Xinyao Zheng et al.
Chronic diabetic wounds are a prevalent and severe complication of diabetes, contributing to higher rates of limb amputations and mortality. N6-methyladenosine (m6A) is a common RNA modification that has been shown to regulate tissue repair...
Hydrogel-integrated exosome mimetics derived from osteogenically induced mesenchymal stem cells in spheroid culture enhance bone regeneration [0.03%]
源自类球体培养中成骨诱导的间充质干细胞的水凝胶整合外体模拟物可促进骨再生
Changlu Xu,Zhi Li,Minjee Kang et al.
Changlu Xu et al.
Exosomes derived from mesenchymal stem cells (MSCs) offer a promising alternative to traditional cell-based therapies for tissue repair by mitigating risks associated with the transplantation of living cells. However, insufficient osteogeni...
Magnesium peroxide-based biomimetic nanoigniter degrades extracellular matrix to awake T cell-mediated cancer immunotherapy [0.03%]
一种基于过氧化镁的仿生纳米点火装置降解细胞外基质以唤醒T细胞介导的癌症免疫疗法
Huisong Hao,Shengjie Sun,Yanan Fu et al.
Huisong Hao et al.
As the elite force of our immune system, T cells play a determining role in the effectiveness of cancer immunotherapy. However, the clever tumor cells construct a strong immunosuppressive tumor microenvironment (TME) fortress to resist the ...