Extracellular vesicles with unique proteomic signatures from self-organized cardiac spheroids under hydrodynamic stimulation [0.03%]
流体动力刺激下心脏类器官释放的携带特异性蛋白质标志物的细胞外囊泡
J E Perez,P Joanne,L Dec et al.
J E Perez et al.
Cardiac extracellular vesicles (EVs) hold promise as cell-free therapeutics for heart repair. However, robust methods to produce scalable, functional and cardiac-specific EVs at high yield remain a limiting factor in their exploitation. Her...
Rethinking the PSMA-mediated tumor targeting of nanocarrier and potentiating co-delivery of PARP/EZH2 inhibitors for robust prostate cancer treatment [0.03%]
通过PSMA介导的纳米载体肿瘤靶向作用，重新评估PARP/EZH2抑制剂联合治疗前列腺癌的效果
Qiang Huang,Yuting Li,Yifan Bi et al.
Qiang Huang et al.
Ligand-mediated targeting of prostate-specific membrane antigen (PSMA) is a prominent strategy in prostate cancer (PCa) theranostics. However, the conventional mechanism of PSMA-targeted nanomedicines, based on passive enhanced permeability...
Biomimetic natural polysaccharide-peptide hydrogels via hierarchical co-assembly: A dynamic nanofibrous shield for active intervention of postoperative adhesions [0.03%]
仿生天然多糖-肽水凝胶的分层自组装研究：一种用于术后粘连的动态纳米纤维屏障材料
Zhaopeng Wang,Daicao Wan,Ting Ma et al.
Zhaopeng Wang et al.
Postoperative adhesions are common and serious complications following abdominal and gynecological surgery, leading to chronic pain, infertility, and intestinal obstruction, yet safe and effective clinical options remain limited. Inspired b...
Switching cell-penetrating peptides from "deliverer" to "enforcer" by hydrophobic amino acid end-tagging to combat intracellular bacterial infections [0.03%]
通过疏水氨基酸端标记细胞穿透肽使其从“递送者”转变为“执行者”以对抗胞内细菌感染
Yongjie Zhu,Mengcheng Wang,Huaxiu Qin et al.
Yongjie Zhu et al.
The presence of recalcitrant intracellular bacteria (ICB) and antimicrobial resistance poses a significant challenge to global public health. Antimicrobial peptides (AMPs) and cell-penetrating peptides (CPPs) play irreplaceable roles in com...
X-ray-triggered intratumoral photosynthesis for oxygenation-enhanced ferroptosis and radiosensitization [0.03%]
基于X射线的肿瘤内仿生光合作用增强铁死亡和放疗协同抗肿瘤作用
Jinjing Hu,Zhanlin Zhang,Duwu Liao et al.
Jinjing Hu et al.
Radiotherapy (RT), a cornerstone treatment, is fundamentally limited by tumor hypoxia-induced radioresistance and the associated need for high doses that cause severe toxicities. Herein, we developed an innovative bionanohybrid platform (Cy...
A recombinant collagen-based nanocomposite hydrogel for programmable full-cycle intelligent management of infected wounds [0.03%]
一种用于程序化全程智能化感染伤口管理的重组胶原基纳米复合水凝胶
Yufeng Li,Jia Wang,Yarong Ding et al.
Yufeng Li et al.
Infected wound healing is a highly dynamic, multistage process, yet most wound dressings remain functionally static and incapable of adapting to its evolving microenvironment. Here, we develop a nanocomposite hydrogel that enables programma...
Oncolytic virus-drug conjugates for increased viral replication efficiency and potentiated cancer chemoimmunotherapy [0.03%]
一种用于增强病毒复制效率和增强癌症化疗免疫疗法的溶瘤病毒-药物共轭体
Tao Zhang,Weiyue Ban,Chengda Yan et al.
Tao Zhang et al.
Oncolytic viruses (OVs) therapy is limited by poor systemic delivery efficiency to tumors, low intratumoral replication efficiency and insufficient immune activation against malignant cancers. Here, we report the autophagy-activated oncolyt...
Engineered senescence-targeting apoptotic extracellular vesicles-laden injectable hydrogel microspheres mitigating nucleus pulposus cell ferroptosis against intervertebral disc degeneration [0.03%]
一种靶向衰老细胞的凋亡型外泌体-载药水凝胶微球缓释体系对抗椎间盘退变中的铁死亡作用机制研究
Pengzhi Shi,Zhuo-Ran Yang,Wenbo Wu et al.
Pengzhi Shi et al.
As the rapid growth of aging population, intervertebral disc degeneration (IVDD) becomes a prevalent degenerative disorder in clinical practice. Ferroptosis-induced senescence in nucleus pulposus cells (NPCs) represents a primary pathologic...
Self-powered photothermal-thermoelectric bioelectronic dressings combined with antioxidant immune regulation accelerate diabetic infected wounds healing [0.03%]
一种自供电光热-热电生物电子绷带结合抗氧化免疫调节加速糖尿病感染创面愈合
Xue Yuan,Jiacheng Shi,Yuhan Zhang et al.
Xue Yuan et al.
Chronic diabetic wounds are plagued by problems such as severe infection, oxidative stress, persistent inflammation. Here, we present an innovative dual-mode thermoelectric bio-dressing that synergistically addresses the multifactorial chal...
Cationic bakuchiol-loaded lipid nanoparticles enhance skin permeation and modulate neuro-immune inflammation and itch pathways in atopic dermatitis [0.03%]
阳离子补骨脂素药用脂质纳米颗粒增强皮肤渗透并调节特应性皮炎的神经免疫炎症和瘙痒通路
Hyung-Goo Kim,Yeon-Hee Shin,Jin Hyun Kim et al.
Hyung-Goo Kim et al.
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by recurrent pruritus and epidermal barrier dysfunction. The long-term use of topical corticosteroids is limited by local and systemic adverse effects, including s...