A thiol-alkyne click chemistry-driven lipoic acid precise delivery platform for targeted therapy of cerebral ischemic stroke via redox homeostasis restoration and neuroinflammatory cascade suppression [0.03%]
一种硫醇-炔点击化学驱动的硫辛酸精准递送平台通过抗氧化和抑制神经炎症级联反应治疗缺血性脑卒中
Xutao Ma,Qiuyue Wang,Xinlei Meng et al.
Xutao Ma et al.
Redox homeostasis imbalance, an early triggering event in cerebral ischemic stroke (CIS), precipitates neuronal death and neuroinflammatory response. The endogenous redox pair α-lipoic acid (LA) and dihydrolipoic acid (DHLA) serve as poten...
Regulation of epithelial-mesenchymal cell-cell partners by complexes of paracrine signals and sulfated oligosaccharides [0.03%]
分泌因子及其硫酸化低聚糖配体调节上皮-间质细胞间的相互作用
Wencheng Zhang,Eliane Wauthier,Yongmei Xu et al.
Wencheng Zhang et al.
Complexes of paracrine signals and synthesized, sulfated oligosaccharides regulate expansion and/or differentiation of human epithelial-mesenchymal cell-cell partners with lineage-stage-specific distinctions exemplified in mature hepatocyte...
A ribosomal protein-rich tumor cell supernatant as a potent inducer of macrophage polarization for synergistic antitumor chemotherapy [0.03%]
一种富含核糖体蛋白的肿瘤细胞上清液可有效诱导巨噬细胞极化并协同增强化疗抗肿瘤效应
Zi-Heng Li,Xinping Zhang,Zihao Wang et al.
Zi-Heng Li et al.
Promoting the M1 polarization of tumor-associated macrophages (TAMs) is a promising strategy to reverse immunosuppressive tumor microenvironment (TME), thereby facilitating tumor treatment. Herein, we develop a tumor treatment approach base...
Mechanoregulating HA-integrated anisotropic fibrous vessel promote AKT-sensitive and YAP-associated endothelial responses and improve regional lymphatic drainage in lymphedema [0.03%]
力学调控的透明质酸集成定向纤维管通过促进AKT敏感及YAP相关的内皮反应改善淋巴水肿局部区域的淋巴引流
Se Rim Jang,Hwayeong Cheon,So Yeun Choi et al.
Se Rim Jang et al.
Secondary lymphedema, characterized by localized tissue swelling caused by lymphatic damage or dysfunction, remains a major clinical challenge that compromises quality of life. Current physical therapies provide only temporary relief, under...
The photothermal-piezoelectric dual-responsive antibacterial prosthesis interface regulates Schwann cell phenotypic conversion to promote the repair of infectious bone defects [0.03%]
光热-压电双响应抗菌假体界面调节施万细胞表型转换促进感染性骨缺损修复
Zhen Ai,Dan Li,Yujia Tian et al.
Zhen Ai et al.
Infected bone defects present a major clinical challenge. Persistent bacterial infection and the inflammatory microenvironment not only directly impede bone healing but also lead to peripheral nerve impairment, which further compromises the...
Heat-treatment-programmed NiTi-5Cu (AH) bioactive orthodontic alloy enables Cu release for antibiofilm and periodontal protection in diabetic oral microenvironment [0.03%]
热处理生物活性镍钛-5铜(AH)正畸合金可在糖尿病口腔微环境中释放铜以抑制菌斑形成和保护牙周组织
Lei Wang,Yimeng Fang,Shuyuan Zhang et al.
Lei Wang et al.
Diabetes-associated hyperglycemia reshapes the oral microenvironment, aggravates biofilm-driven inflammation, and compromises the safety and efficacy of orthodontic treatment. Here, we develop a heat treatment-programmed bioactive orthodont...
Bioactive molecule-derived covalent organic frameworks as biocompatible scaffolds for targeted AKR1B10 inhibition in alcoholic liver disease [0.03%]
一种用于酒精性肝病靶向AKR1B10抑制的生物相容性支架分子衍生的共价有机框架
Jialu Zhuang,Guoqiang Pan,Juan Wang et al.
Jialu Zhuang et al.
Alcoholic liver disease (ALD) incidence is rising globally, yet effective targeted therapies remain elusive. In recent years, bioactive molecules have gained prominence in liver disease research. However, no natural inhibitors targeting key...
Ke Huang,Haomeng Wang,Tao Zhu et al.
Ke Huang et al.
Chimeric antigen receptor (CAR) immune cell therapy has revolutionized the treatment of hematologic malignancies, yet conventional ex vivo manufacturing remains costly, complex, and logistically demanding. Emerging in vivo engineering strat...
Enhanced piezoelectric collagen with aligned microstructure for synergistic electro-topological skeletal muscle regeneration [0.03%]
具有增强型压电微结构的胶原蛋白促进协同性电-拓扑肌肉再生
Jiaxin Hao,Gaopeng Dang,Yingbo Ji et al.
Jiaxin Hao et al.
Volumetric muscle loss (VML) often leads to irreversible functional impairment due to limited endogenous regeneration and poor outcomes of current therapies. Collagen fibers are piezoelectric biomaterials and key components of the skeletal ...
Geometrically adaptive hydrogel attenuates osteoarthritis via metabolic reprogramming and defect sealing [0.03%]
几何适应性水凝胶通过代谢重编程和缺损封端缓解骨关节炎
Jinlong Zhang,Xinmeng Zha,Xiangxiu Wang et al.
Jinlong Zhang et al.
Effective treatment for osteoarthritis (OA) remains challenging because current therapies do not simultaneously restore biomechanical support and modulate the pathological intra-articular microenvironment. Here, we developed an injectable d...