Self-powered electro-activated MgxFe1-xS2 scaffold for gas-ion therapy in osteosarcoma suppression and bone regeneration [0.03%]
自驱动电活化MgxFe1-xS2支架用于气离子治疗以抑制骨肉瘤和促进骨再生
Botao Lu,Zeyu Chen,Shichao Yan et al.
Botao Lu et al.
Postoperative treatment of osteosarcoma faces the dual challenges of tumor recurrence and extensive bone defect repair, necessitating the development of a synergistic strategy capable of simultaneously eliminating residual tumor cells and p...
A carrier-within-a-carrier system with calcium nanoparticles encapsulated in β-cyclodextrin-polysaccharide hydrogel for verteporfin delivery and radiosensitization in orthotopic osteosarcoma [0.03%]
一种递送载体：将β-环糊精多糖水凝胶包封的钙纳米颗粒用于正交位肿瘤模型中verteporfin的传递和放射增敏研究
Jiayi Liu,Xuehao Tian,Alifujiang Hairulajiang et al.
Jiayi Liu et al.
Osteosarcoma remains a clinical challenge due to its high invasiveness, early metastasis, and intrinsic radioresistance, which collectively limit the efficacy of conventional treatments and immunotherapy. Here, we developed a pH-responsive ...
Transient culture of adult human hepatocytes as organoids improves engineered liver engraftment [0.03%]
类器官化的成人肝脏上皮细胞系具有更好的移植治疗潜力
Sarah H Saxton,Inkyung Kang,Shannon Mitchell et al.
Sarah H Saxton et al.
Bioengineered livers could serve as a bridge or alternative to whole organ transplantation for patients suffering from liver disease. However, identifying cellular configurations that promote adult human hepatocyte survival after tissue tra...
Triple-modal PPy/ZIF-8 nanoparticles amplify autophagy and block autophagic flux via photothermal-ROS-zinc ion synergy for cancer therapy [0.03%]
三模态PPy / ZIF-8纳米粒子通过光热- ROS-锌离子协同作用放大自噬并阻断自噬流量用于癌症治疗
Canyi Chen,Qinqing Tang,Qinyao Xu et al.
Canyi Chen et al.
Targeted autophagy regulation holds great promise for antitumor therapy, whereas conventional single-modal autophagy interventions easily induce compensatory escape of tumor cells and fail to transform protective autophagy into a lethal phe...
A new biomaterial and molecular imaging platform: Click-coupled dual-responsive fluorescent signaling for deciphering the ROS-RSS imbalance in kidney injury [0.03%]
一种新的生物材料和分子影像平台：适用于肾脏损伤中ROS-RSS失衡解析的“点击化学”双刺激响应型荧光信号报告体系研究
Yongchuang Li,Haiyue Liu,Songhan Liu et al.
Yongchuang Li et al.
As the sophisticated "purification factory", kidney performs pivotal functions from blood filtration to endocrine regulation. Consequently, renal injury will trigger "domino effect" culminating in multiple organ failure, posing unavoidable ...
Inflammation-triggered nanodrug delivery microneedles targeting pathogenic COX2+ endothelial cell-mediated glycocalyx degradation to ameliorate psoriasis [0.03%]
炎症触发的纳米药物输送微针，靶向病理性COX2+内皮细胞介导的糖萼降解以改善银屑病
Zelin Ou,Keyi Zou,Linxi Zeng et al.
Zelin Ou et al.
Psoriasis is a chronic, immune-mediated inflammatory skin disorder. The vascular endothelium serves as the final barrier preventing circulating immune cells from entering inflamed skin, yet its role in psoriasis pathogenesis and therapeutic...
Engineering chirality-dependent nanomedicines for neuroprotection by synergistic PANoptosis attenuation in ischemic stroke [0.03%]
通过协同抑制PANoptosis工程手性依赖型纳米药物用于缺血性卒中的神经保护
Chundongqiu Xia,Zhimeng Cui,Wenhui Jiang et al.
Chundongqiu Xia et al.
Despite substantial breakthroughs in acute care, ischemic stroke remains a pressing, unresolved crisis in clinical practice and public health. Current therapies, which primarily depend on early revascularization, provide limited protection ...
Development and mechanistic investigation of 3D-printed biomimetic corpus cavernosum seeded with MSCs for restoring erectile function in pigs [0.03%]
用于恢复猪阴茎勃起功能的三维打印仿生海绵体及其机理研究播种MSCs
Zhenxing Wang,Hanchen Liang,Tan Ye et al.
Zhenxing Wang et al.
Penile injury induces rapid structural disruption of the corpus cavernosum, ultimately culminating in erectile dysfunction (ED). Owing to the inherently limited regenerative capacity of injured tissue, current therapies fail to restore both...
Ultrasound-induced cascade nanozyme catalysis for enhanced tumor cell pyroptosis and systemic anti-tumor immunity [0.03%]
超声波诱导的级联纳米酶催化增强肿瘤细胞焦亡和全身抗肿瘤免疫
Shuheng Qin,Mengchu Zhao,Weishu Gao et al.
Shuheng Qin et al.
High levels of reactive oxygen species (ROS) are critical for inducing efficient pyroptosis. However, conventional sonosensitizers often exhibit limited ROS generation capacity, thereby restricting their pyroptotic efficacy. Herein, we repo...
Architecture-driven engineered lattice tetrahedral micro-scaffolds for extraskeletal osteogenesis [0.03%]
一种用于异骨性组织工程的基于架构驱动型工程蜂窝状四面体微支架
Liya Ai,Lingling Zheng,Dan Chen et al.
Liya Ai et al.
While granular bone graft materials exhibit favorable surgical maneuverability, they still present critical drawbacks in clinical scenarios such as extraskeletal osteogenesis, including unstable osteogenic space maintenance and insufficient...