Burning windjammer: Multi-rotor engineered photothermal agent with 87% photothermal conversion for antimicrobial treatment [0.03%]
用于抗菌治疗的光热转换效率高达87%的多旋翼工程化光热剂
Xinyue Yang,Mingqian Wang,Jun Zhu et al.
Xinyue Yang et al.
The evolution of drug-resistant pathogens has significantly diminished the efficacy of antibiotics. Photothermal therapy has appeared as a promising approach for the curing of infectious diseases on account of its high therapeutic efficienc...
Reversing fibroblast-to-myofibroblast transition using surface-engineered nanoparticles to potentially ameliorate fibrotic diseases [0.03%]
利用表面工程纳米颗粒逆转成纤维细胞向肌成纤维细胞转变以潜在改善纤维化疾病
Xiao Yu,Steve Smith,Congzhou Wang
Xiao Yu
Fibroblast-to-myofibroblast transition (FMT) is cellular transformation process driving the pathogenesis of fibrotic disorders such as pulmonary fibrosis and scleroderma. Despite advances in anti-fibrotic therapies, existing treatments prim...
A lactate capture-sensing platform for facilitating early differential diagnosis of minimal change disease and focal segmental glomerulosclerosis in renal diseases [0.03%]
用于肾病微小病变与局灶节段性肾小球硬化早期鉴别诊断的乳酸捕获传感平台
Jiayi Fan,Bing Zhang,Yongtao Yu et al.
Jiayi Fan et al.
Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are primary glomerular disorders, and currently the invasive renal biopsy combined with gene sequencing are required for definitive diagnosis, which is apparently a ...
Synthetic peptide hydrogels as a model of the bone marrow niche demonstrate efficacy of a combined CRISPR-CAR T-cell therapy for acute myeloid leukaemia [0.03%]
以合成肽水凝胶作为骨髓生态位模型展示出结合CRISPR-CAR-T细胞疗法治疗急性髓系白血病的有效性
W Sebastian Doherty-Boyd,P Monica Tsimbouri,Vineetha Jayawarna et al.
W Sebastian Doherty-Boyd et al.
Leukaemias, driven by mutations in haematopoietic stem cells (HSCs), rely on interactions with the bone marrow (BM) niche and other cell populations such as mesenchymal stromal cells (MSCs) for growth and survival. While chimeric antigen re...
Targeting neuronal cuproptosis and neuroinflammation with biomimetic nanoparticle for the therapy of radiotherapy-induced brain injury [0.03%]
靶向神经铜依赖性细胞死亡和神经炎症的仿生纳米颗粒放射增敏策略治疗放射性脑病
Baofang Wu,Yibin Zhang,Shaojie Li et al.
Baofang Wu et al.
While intracranial radiation therapy is commonly used in the treatment of intracranial and extracranial tumors, it inevitably contributes to radiotherapy-induced brain injury (RBI). This has induced severe clinical events, such as progressi...
Spatiotemporal organelle delivery and activation of type I AIE photosensitizers and siRNA for near-infrared fluorescence image-guided immunotherapy [0.03%]
时空递送器脏和I型AIE光敏剂及siRNA用于免疫治疗的近红外荧光影像引导
Ming-Jie Dong,Xuan Wang,Jinlong Yang et al.
Ming-Jie Dong et al.
The spatiotemporal delivery and activation of small-molecule drugs and macromolecular biologics at the organelle level for cancer immunotherapy remain a significant challenge. To address this issue, we developed TPR, an all-in-one nanoplatf...
Hydrolytically stable, functionalizable, and tunable zwitterionic hydrogels for 3D cell culture within a non-fouling microenvironment [0.03%]
在非污染微环境中用于三维细胞培养的两性水凝胶的制备及其稳定性、功能性与调节性的研究
Di Liu,Erica K Wagner,Shaili Lakhotia et al.
Di Liu et al.
Zwitterionic hydrogels are promising scaffolds for 3D cell culture due to their strong hydration and resistance to non-specific protein adsorption. Unlike animal-derived matrices like Matrigel, they provide a chemically defined, biologicall...
Development of an innervated human skin equivalent to model nociceptive circuitry in vitro [0.03%]
一种用于体外模拟伤害性感觉回路的人工神经支配皮肤的开发
Daniele Bellantoni,Costantino Casale,Claudia Mazio et al.
Daniele Bellantoni et al.
The reconstruction of innervated skin equivalents in vitro to recapitulate the somatosensory system is central to advancing our understanding of nociceptive circuitry and holds significant potential for various industrial applications. As s...
Polypeptide-based nanocarriers from aqueous ROPISA: Shape-dependent performance in colorectal and breast cancer models [0.03%]
基于水相ROPISA的多肽纳米载体：形状依赖性在结直肠癌和乳腺癌模型中的表现
Hannah Beauseroy,Sabina Quader,Xueying Liu et al.
Hannah Beauseroy et al.
Polypeptide-based nanocarriers are key to the field of drug delivery, however the influence of morphology on their performance remains underexplored. In this study, we present a novel method for the synthesis of fluorescent worm-like nanopa...
Hydrogel-guided p-LOX nanodrug delivery modulates metabolic microenvironment for cartilage repair in osteoarthritis [0.03%]
透明质酸水凝胶负载p-LOX纳米药丸重编程关节软骨代谢微环境治疗骨关节炎
Yuna Qian,Sixiang Wang,Yongqiang Sha et al.
Yuna Qian et al.
Osteoarthritis (OA) is a common degenerative disorder characterized by joint inflammation and progressive loss of cartilage. Anti-OA therapies are still lacking. The hallmark of OA pathoetiology is an imbalance in metabolic activities that ...