Injectable CRISPRa-microspheres for targeted A20 activation rescue age-related osteogenic impairment via senescence mitigation [0.03%]
可通过注射CRISPRa微球靶向激活A20救援衰老相关成骨功能障碍的研究
Jie Chen,Zhen Wang,Yawei Du et al.
Jie Chen et al.
Age-related osteogenic failure in bone defect repair remains a significant clinical challenge, primarily due to persistent chronic inflammation-induced stem cell senescence. To address this, we engineered injectable CRISPRa-based gene-editi...
Novel PEEK fabrication using fused strand deposition reduces inflammation and enhances MSC differentiation promoting bone growth and implant osseointegration [0.03%]
新型PEEK制造工艺可减少炎症并促进MSCs分化从而促进骨生长和种植体骨结合
David Joshua Cohen,Jingyao Deng,Todd M Reith et al.
David Joshua Cohen et al.
Spine fusion devices fabricated from polyether ether ketone (PEEK) using traditional machining or with surface pores created by salt leaching result in a fibrous connective tissue interface. To overcome this limitation, we used fused strand...
Selenium-albumin corona rinse ameliorates diabetic periodontitis by inhibiting inflammation, anti-bacterial and improving osteogenesis via activating TrxR1/ROS/β-catenin anti-oxidation cascade [0.03%]
人血清白蛋白封端的硒化纳米颗粒漱口水通过激活TrxR1/ROS/β-catenin抗氧化级联改善糖尿病性牙周炎
Xinrong Zou,Xinyao Fan,Ping Xu et al.
Xinrong Zou et al.
Diabetes mellitus (DM) aggravates periodontitis due to disordered glucose metabolism, leading to accelerated bone destruction and increasing dental plaque reproduction to induce local inflammation. The hyperglycemic state of DM leads to rea...
Selective killing of cancer-associated fibroblasts by ultrasound-mediated mechanical forces [0.03%]
声波介导的机械力选择性杀伤癌相关成纤维细胞
Gomathi Sankar,Arka Roy Choudhury,Rashmita Luha et al.
Gomathi Sankar et al.
Recent studies show that stretch/ultrasound (US)-generated mechanical forces cause selective apoptosis in several cancer cells, tumor organoids and animal models without damaging normal cells. Cancer-associated fibroblasts (CAFs) are an int...
Ultrasound-responsive piezoelectric hydrogel attenuates oxidative stress-induced nucleus pulposus senescence via AMPK-FOXO1a-mediated mitophagy for intervertebral disc regeneration [0.03%]
超声波响应压电水凝胶通过AMPK-FOXO1a介导的线粒体自噬缓解氧化应激诱导的髓核细胞衰老促进椎间盘再生
Wenbo Wu,Zhangrong Cheng,Pengzhi Shi et al.
Wenbo Wu et al.
The progression of intervertebral disc degeneration (IDD) is closely linked to the nucleus pulposus cells (NPCs) senescence driven by oxidative stress and extracellular matrix (ECM) abnormalities. This study presents an ultrasound-responsiv...
Antimicrobial coated intracortical probes reduce invading microbe abundance and subsequent neuroinflammation [0.03%]
载有抗菌剂的皮质内电极可减少微生物入侵及后续神经炎症反应
G Burkhart,S E Grabinski,J J Wang et al.
G Burkhart et al.
Intracortical microelectrodes allow for the recording of neural signals in the brain but show decreased recording performance over time. This failure is due primarily to the neuroinflammatory response triggered by microelectrode implantatio...
Selenium-functionalized hydrogel microspheres promote nucleus pulposus reconstruction by activating selenoprotein-mediated mitochondrial redox homeostasis and energy metabolism [0.03%]
硒功能化水凝胶微球通过激活硒蛋白介导的线粒体氧化还原稳态和能量代谢促进髓核再生
Jiaheng Lv,Yujie Shen,Quan Zhou et al.
Jiaheng Lv et al.
Degeneration of the nucleus pulposus (NP) is the primary contributor to lumbar intervertebral disc (IVD) disorders. While clinical discectomy is frequently employed to address advanced stages of IVD degeneration, this surgical intervention ...
Cationic nanoparticle targets cGAS-STING axis to drive functional orofacial muscle regeneration [0.03%]
阳离子纳米粒子靶向cGAS-STING轴驱动功能面部肌肉再生
Hao Sui,Xu Cheng,Fangman Chen et al.
Hao Sui et al.
Post-injury orofacial muscle is highly prone to fibrosis, partly due to a dysregulated microenvironment shaped by cell-free DNA (cfDNA). Muscle stem cell, i.e., muscle satellite cell (MuSCs), are key mediators of regeneration and are highly...
Glycolysis-inhibiting tumor cell-derived microparticles to enhance immunogenic cell death for synergistic cancer immunotherapy [0.03%]
用于增强免疫原性细胞死亡的糖酵解抑制肿瘤细胞来源微颗粒以实现协同癌症免疫治疗
Miya Zhang,Jian Xu,Zhijuan Yang et al.
Miya Zhang et al.
In situ vaccination represents a promising cancer immunotherapy strategy, yet its efficacy in solid tumors remains limited, primarily due to the immunosuppressive tumor microenvironment (TME) and resistance to immunogenic cell death (ICD)-i...
Degradable biomimetic stent with hydrogel and directional TGF-loaded nano-fiber membrane for the treatment of esophageal fistula [0.03%]
含水凝胶及载TGF纳米纤维膜定向释放膜的可降解仿生支架治疗食管瘘的研究
Yiran Zhang,Junyuan Xiao,Tonglei Fang et al.
Yiran Zhang et al.
Esophageal fistulas (EFs) arising from esophageal cancer, trauma, or iatrogenic injury can lead to severe complications. While covered metal stents can effectively occlude EFs, their long-term implantation may result in migration, in-stent ...