An immunomodulatory hydrogel encapsulating dental follicle stem cell-derived small extracellular vesicles promotes neutrophil clearance and periodontal bone regeneration [0.03%]
负载牙囊干细胞来源的小细胞外囊泡的免疫调控水凝胶促进中性粒细胞清除及牙周骨再生
Maoxue Li,Yuqi Wen,Yi Ding et al.
Maoxue Li et al.
Periodontitis, characterized by progressive alveolar bone resorption and periodontal defect formation, remains a major clinical challenge driven by bacterial infection and a dysregulated inflammatory immune microenvironment. Neutrophils, as...
Nanoscale copper ethoxide enables immunologically enhanced hepatoma radio-immunotherapy via synergistic cuproptosis and metabolic oxidative stress [0.03%]
纳米级铜乙酸盐通过协同杯中毒和代谢氧化应激增强免疫性肝癌放射免疫疗法
Songling Liu,Yang Liu,Qin Fan et al.
Songling Liu et al.
Metal alkoxides hold promise in catalysis and materials science, but their rapid hydrolysis in aqueous media represents a major limitation for biomedical applications. To harness this intrinsic reactivity therapeutically, we developed a fac...
Hydrogel delivery of demineralized bone matrix augmented with ROS-triggered biomineralization and Trb3 activation for enhanced bone regeneration [0.03%]
ROS触发的生物矿化和Trb3激活的脱矿骨基质增强羟胶原蛋白骨再生
Zhi Li,Changlu Xu,Minjee Kang et al.
Zhi Li et al.
Cranial bone defects remain a significant clinical challenge due to limited intrinsic regenerative capacity and an adverse oxidative microenvironment that impairs osteogenesis. Demineralized bone matrix (DBM), a clinically used bone graft s...
Corrigendum to "Self-intensified synergy of a versatile biomimetic nanozyme and doxorubicin on electrospun fibers to inhibit postsurgical tumor recurrence and metastasis" [Biomaterials 293 (2023) 121942] [0.03%]
关于“一种通用的仿生纳米酶与多柔比星在电纺丝上的自我增强协同作用，抑制术后肿瘤复发和转移”一文的勘误[Biomaterials 293 (2023) 121942]
Yongwei Hu,Yanteng Xu,Rachel L Mintz et al.
Yongwei Hu et al.
Published Erratum
Biomaterials. 2026 Aug 7:124515. DOI:10.1016/j.biomaterials.2026.124515 2026
Coordination-environment engineering of a sulfur-modified copper single-atom nanozyme enables electronic structure modulation toward systemic antineoplastic therapy [0.03%]
硫修饰铜单原子纳米酶的配位环境工程调控电子结构用于全身抗肿瘤治疗
Weisheng Zhu,Ruonan Li,Xin Luo et al.
Weisheng Zhu et al.
Precise manipulation of atomic coordination environments in single-atom nanozymes offers a powerful strategy to regulate catalytic activity, yet achieving simultaneous enhancement of active-site density and intrinsic catalytic efficiency re...
Photoresponsive electrospun fiber scaffold enables on-demand cytokine delivery for biomimetic endochondral bone regeneration [0.03%]
光响应静电纺纤维支架能够实现按需递送细胞因子用于仿生内ochondral骨再生
Chengao Gao,Nan Tang,Jiahao Li et al.
Chengao Gao et al.
Critical-sized bone defect repair remains a formidable challenge because conventional approaches cannot recapitulate the temporally coordinated cascade of endochondral ossification. Here, we report a biomimetic, temporally programmed cytoki...
Biomimetic aligned scale-like nanotopographic scaffold reprograms resorption-dominant remodeling in diabetic sockets to enhance alveolar ridge preservation [0.03%]
类骨质鳞片状纳米拓扑支架可重塑糖尿病窝裂吸收主导的重塑模式以增强牙槽ridge保存能力
Jiawei Xing,Jiacheng Lv,Ze He et al.
Jiawei Xing et al.
Spatiotemporally patterned alveolar ridge resorption after tooth extraction compromises subsequent implant placement and esthetic rehabilitation. This challenge is aggravated in diabetes, where chronic inflammation and excessive osteoclast ...
Macrophage polarization-inducible cholesterol lipid-assisted nanoparticles prime systemic antitumor immunity [0.03%]
巨噬细胞极化诱导胆固醇脂质纳米颗粒辅助调节全身抗肿瘤免疫反应
Bofu Ma,Miao Su,Boya Yu et al.
Bofu Ma et al.
Nanomaterials with intrinsic biological activity can directly participate in disease treatment, emerging as a pivotal focus in the development of next-generation therapeutics. In this study, we synthesized a library of cholesterol lipids be...
Bioprinted cell-instructive lung-dECM constructs for reconstructing an immuno-regenerative pulmonary microenvironment [0.03%]
用于重建免疫再生性肺微环境的生物打印细胞指令性肺脱细胞基质构建体
Soham Ghosh,Falguni Pati
Soham Ghosh
Pulmonary tissue engineering requires scaffolds that combine parenchymal mechanical compliance with extracellular matrix-bound instructive cues, yet soft materials often lack print fidelity. Here, we developed decellularized lung matrix (dL...
A boronate-phenolic network nanoplatform carrying dimethyl itaconate for ameliorating neovascular age-related macular degeneration [0.03%]
负载双甲基衣康酸的硼酸-酚类网络纳米平台用于改善新生血管年龄相关性黄斑变化
Yufeng Xu,Mingyu Xu,Jiqiao Qie et al.
Yufeng Xu et al.
Age-related macular degeneration (AMD), particularly its neovascular form driven by choroidal neovascularization (CNV), remains leading cause of irreversible blindness worldwide. Current anti-vascular endothelial growth factor (VEGF) therap...