Extracellular matrix glycation epigenetically regulates brain aging and neurodegeneration in the in vitro aged neurovascular model [0.03%]
细胞外基质糖化通过表观遗传学调节脑衰老和神经退行性病变的体外模型研究
Minjeong Jang,Hae-June Lee,Eun U Seo et al.
Minjeong Jang et al.
As life expectancy continues to rise, addressing aging and age-related diseases becomes crucial for maintaining a healthy lifestyle. Advanced glycation end-products (AGEs) accumulate in brain tissue as we age, co-localizing with amyloid β ...
Bone marrow microenvironment-responsive polymeric-drug/siRNA regulates leukemia stem cells assisting for prevention of AML relapse [0.03%]
骨髓微环境响应型聚合物药物/siRNA调节白血病干细胞以预防AML复发
Shihong Cheng,Xiaohan Kong,Yiqiu Zhang et al.
Shihong Cheng et al.
Acute myeloid leukemia (AML) remains a formidable hematological malignancy with a poor prognosis, largely due to the limited success of existing treatments in effectively targeting leukemia stem cells (LSCs). These cells are adept at migrat...
Corrigendum to 'M1-macrophage membrane-camouflaged nanoframeworks activate multiple immunity via calcium overload and photo-sonosensitization' [Biomaterials 320 (2025) 123287] [0.03%]
关于“M1型巨噬细胞膜伪装的纳米框架通过钙超载和光声敏化激活多重免疫”一文的勘误[Biomaterials 320 (2025) 123287]
Yinjing Shen,Nuo Yu,Wenjing Zhao et al.
Yinjing Shen et al.
Published Erratum
Biomaterials. 2025 Jun 19:123514. DOI:10.1016/j.biomaterials.2025.123514 2025
Minimally invasive upconversion optogenetics for Parkinson's disease treatment [0.03%]
用于帕金森病治疗的微创上转换光遗传学方法
Xinsheng Li,Xiaoran Wang,Ting Zhou et al.
Xinsheng Li et al.
The treatment of Parkinson's disease (PD) is greatly limited by the side effects of levodopa, the current gold standard medication, which can cause severe motor complications. Optogenetic stimulation holds promise for PD therapy, but it has...
Increasing polycation hydrophobicity in mRNA polyplex vaccines enhances the efficacy of humoral and cellular immunity induction [0.03%]
Nan Qiao,Mao Hori,Mitsuru Naito et al.
Nan Qiao et al.
Polycation-based mRNA delivery systems, known as polyplexes, hold significant potential for use in mRNA vaccines and therapeutics. However, their performance has been suboptimal in infectious disease vaccines, which require the induction of...
Conjugation of peptides to a dendrimer surface to promote the proliferation and differentiation of human pluripotent stem cells into cardiomyocytes and retinal pigment epithelium [0.03%]
肽通过连接物 conjugation 连接到树形聚合物的表面，促进人多能干细胞向心肌细胞和视网膜色素上皮分化
Tzu-Cheng Sung,Wen-Hui Chao,Zeyu Tian et al.
Tzu-Cheng Sung et al.
Human pluripotent stem cells (hPSCs), of which differentiated cells can be used in cell therapy and regenerative medicine, cannot proliferate on traditional polystyrene surfaces. Instead, hPSCs are typically cultivated on surfaces coated wi...
Amplifying tumor recognition and drug susceptibility by multivalent ApDC assembly to combat with tumor cell heterogeneity [0.03%]
利用多价ApDC组装放大肿瘤识别和药物敏感性以对抗肿瘤细胞异质性
Jiahuan Wang,Hai Liu,Xinyue Ran et al.
Jiahuan Wang et al.
Molecular target-based therapeutics like antibody-drug conjugates (ADCs) have been proved effective in clinical trials. However, tumor cell heterogeneity and weak-positive expression of tumor antigens impeded the clinical efficiency on some...
Biomimetic nanoplatforms for combined DDR2 inhibition and photothermal therapy in dense breast cancer treatment [0.03%]
用于密集型乳腺癌治疗的结合DDR2抑制和光热疗法的类生物纳米平台
Yan Chen,Ye Yu,Yonghao Fan et al.
Yan Chen et al.
Breast cancer treatment remains challenging due to the dense, fibrotic tumor microenvironment (TME), which is dominated by cancer-associated fibroblasts (CAFs), hinders drug delivery and promotes therapy resistance. While photothermal thera...
In situ incorporation of boronate into carbonized alginate nanogels for targeted inhibition of triple-negative breast cancer metastasis by inducing cytoskeletal disruption, cell growth arrest, and apoptosis [0.03%]
原位将硼酸掺入碳化海藻酸纳米凝胶中，通过诱导细胞骨架破坏、细胞增殖停滞和凋亡来针对抑制三阴性乳腺癌转移
Saumyadip Sarkar,Chen-Yow Wang,Pang-Hung Hsu et al.
Saumyadip Sarkar et al.
Metastasis is the primary cause of cancer mortality, and its prevention is particularly challenging due to the complex tumor microenvironment. Carbon nanomaterials are well known to act as drug delivery systems for therapeutics. Nonetheless...
Modulating tumor acidity with hydroxyethyl starch-based nanoparticles by targeting CA9 to eliminate cancer stem cells and overcome immunosuppression [0.03%]
利用CA9靶向的羟乙基淀粉基纳米粒子调节肿瘤酸性以消除癌症干细胞并克服免疫抑制
Qingyuan Deng,Ao Hua,Qingfu Zhao et al.
Qingyuan Deng et al.
The acidic microenvironment in solid tumors, primarily driven by Warburg effect, promotes tumor progression, immune evasion, and resistance to therapy. Cancer stem cells (CSCs), a critical subset within tumor tissues, exacerbate this acidit...