Triple-molded, reinforced arrowhead microneedle patch of dual human-derived matrix for integrated management of diabetic wounds [0.03%]
一种三重模具、强化箭头微针贴片，用于糖尿病伤口的综合管理，该贴片源自双重人源基质
Ze-Ming Zhuang,Yong Wang,Li Chen et al.
Ze-Ming Zhuang et al.
Platelet-rich plasma (PRP) is often administered with gauze for wound management clinically. However, this treatment method suffers from poor contact, drug wastage and limited delivery depth compromising therapeutic efficacy. Local injectio...
Regulation of cGAS-STING pathway with inhalable nanozyme in acute lung injury [0.03%]
通过吸入型纳米酶调节cGAS-STING通路以治疗急性肺损伤
Xichun Qin,Zi Fu,Leilei Wu et al.
Xichun Qin et al.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening conditions marked by severe inflammation, oxidative stress, and disruption of the alveolar-capillary barrier. The limited efficacy of current therap...
The development of a collagen-nanoscale hydroxyapatite three-dimensional (3D) in vitro culture system for reproducing osteocyte differentiation and tissue mineralization [0.03%]
一种胶原-纳米羟基磷灰石三维（3D）体外细胞培养系统的发展，用于重现成骨细胞分化和组织矿化作用
Xiaoyu Xu,Brian T Golz,Brennan T Flannery et al.
Xiaoyu Xu et al.
Activation of bone tumor-eating macrophages via assembling and co-delivering 3D printed scaffold [0.03%]
通过组装和共递送3D打印支架激活骨肿瘤吞噬巨噬细胞
Cuidi Li,Zhenjiang Ma,Xin Sun et al.
Cuidi Li et al.
The current post-surgery treatment of bone tumors with 3D-printed implants is facing the dilemma of difficulty in reducing the recurrence rate, which is closely related to the inability of the implants to reverse M2 polarization and the los...
Multi-bioactive poly(amino acid)-metal-organic framework nanocomposite for reinforced cascading photodynamic immunotherapy of cancer [0.03%]
用于癌症强化级联通光动力免疫治疗的多生物活性聚(氨基酸)-金属有机框架纳米复合材料
Jichao Sun,Zhitong Zhao,Xue Wei et al.
Jichao Sun et al.
Photodynamic immunotherapy (PDIT) represents a promising synergistic approach to enhance the efficacy of cancer immunotherapy by inducing immunogenic cell death (ICD) through the generation of reactive oxygen species (ROS). However, the ant...
A controllable self-amplifying oxidative stress strategy for boosting noninvasive sonodynamic therapy and synergistic immunotherapy [0.03%]
一种可控的自放大氧化应激策略，用于增强非侵入性声动力疗法和协同免疫治疗
Mingting Zhu,Jiacheng Liu,Yan Li et al.
Mingting Zhu et al.
The combined application of sonodynamic therapy (SDT) and immune checkpoint blockade may be hindered by the antioxidant defense mechanisms of tumor cells and the immunosuppressive tumor microenvironment (TME). SDT may be enhanced through na...
Development of a multifunctional, injectable biomaterial using hyaluronan as a bioactive nanocarrier [0.03%]
一种多功能注射型生物材料的开发：透明质酸作为生物活性纳米载体
Louis S Paone,Ying Jin,Julien Bouyer et al.
Louis S Paone et al.
Hyaluronic acid-based biomaterials provide diverse functionality due to the inclusion of multiple bioactive domains within the glycosaminoglycan molecule. This attribute is particularly promising for regenerative strategies to treat central...
Regulation of nuclear deformation via spatiotemporal modulation of cytoskeleton forces on photo-switchable surfaces [0.03%]
基于光响应表面胞质骨架力时空调控实现细胞核变形研究
Francesca Mauro,Carlo F Natale,Valeria Panzetta et al.
Francesca Mauro et al.
Nuclear deformations are known to influence the 3D organization of chromatin, ultimately regulating cell fate decisions through gene transcription activity. Understanding and controlling this relationship offers valuable insights into funda...
Computationally-guided multifunctional nanoplatform for enhanced oral delivery and targeted therapy of Helicobacter pylori using herbal bioactives [0.03%]
基于计算的多功能纳米平台用于口服给药和使用草本生物活性物质针对幽门螺杆菌的治疗
Chuqiu Zhang,Haobo Chen,Yuanjing Zou et al.
Chuqiu Zhang et al.
Herbal bioactive ingredients offer considerable promise for the eradication of Helicobacter pylori (H. pylori) due to their inherent non-toxicity, cost-effectiveness, and diverse pharmacological activities. However, their clinical utility i...
GsMTx4-loaded GelMA promotes tendon regeneration and suppresses heterotopic ossification via the Apelin signaling pathway [0.03%]
负载GsMTx4的GelMA通过Apelin信号通路促进肌腱再生并抑制异位骨化
Lei Lei,Zhenkang Wen,Xueyou Zhang et al.
Lei Lei et al.
Tendon injuries pose significant challenges in both athletes and the general population, often leading to prolonged healing, impaired functionality, and increased risk of re-injury. Current treatment options are limited and often yield unfa...