Mechanistic insights and therapeutic applications of metal-based nanomaterials in oral infectious diseases: Current advances and future perspectives [0.03%]
金属基纳米材料在口腔感染性疾病中的作用机制及治疗应用：当前进展与未来前景
Yijuan Wu,Jun Liao,Yicheng Pu et al.
Yijuan Wu et al.
Oral infectious diseases, including dental caries, pulpitis, periodontitis, peri-implantitis, and osteomyelitis of the jaws, are among the most prevalent conditions in dentistry, primarily caused by bacterial infections. Traditional treatme...
Heavy-atom-effect enhanced singlet oxygen generation of carbon dots for lipid-targeting tumor photodynamic therapy inducing ferroptosis [0.03%]
重金属效应增强的碳点单线态氧生成作用及其针对脂质的肿瘤光动力治疗诱导铁死亡的作用
Jian Li,Xiaokuang Xue,Tiejin Chen et al.
Jian Li et al.
Carbon dots (CDs) have garnered significant attention in the field of tumor photodynamic therapy (PDT) in recent years, attributed to their superior optical properties and favorable biocompatibility. In the research on PDT inducing tumor fe...
Epidermal and dermal cell-composed organospheres to assess microplastic-induced skin toxicity [0.03%]
含表皮和真皮细胞的类器官球体用于评估微塑料引起的皮肤毒性
Yunxia Hu,George Michael Nicolas,Yongde Cai et al.
Yunxia Hu et al.
The alarming prevalence of microplastics (MPs) in personal care products and their inherent presence in animals and humans necessitate the development of alternative experimental approaches to evaluate their cytotoxicity, mechanisms, and lo...
Precisely deliver toll-like receptor agonists using a dual-responsive nanovaccine for effective cancer immunotherapy [0.03%]
利用双重响应型纳米疫苗精准传递 Toll 样受体激动剂实现有效的癌症免疫治疗
Yumeng Xing,Ruiying Wu,Zhaoyuan Tu et al.
Yumeng Xing et al.
Cancer vaccines have demonstrated their potential in cancer immunotherapy. However, various agonists in free form are easily to be eliminated in vivo and may cause systemic adverse effects. It remains a challenge to effectively target and r...
In situ self-growth nano-selenium hydrogel coating alleviates surface thrombosis of blood-contacting devices by inactivating inflammatory cells [0.03%]
原位生长的纳米硒水凝胶涂层通过灭活炎症细胞缓解血液接触装置表面血栓形成
Yao Xiong,Yage Hu,Jiaqi Wang et al.
Yao Xiong et al.
The formation of thrombi in blood-contacting devices is accompanied by a several risks that can be life-threatening. Specifically, the process of blood exposure immediately after implantation triggers an immune response aimed at removing fo...
A phosphatidylserine-targeted self-amplifying nanosystem improves tumor accumulation and enables efficient tumor therapy by modulating anticancer immunity [0.03%]
一种靶向磷脂酰丝氨酸的自放大纳米系统通过调节抗癌免疫提高肿瘤蓄积并实现有效的肿瘤治疗
Yingjie Ren,Qin Fan,Xinhao Yao et al.
Yingjie Ren et al.
Tumor heterogeneity disrupts the consistent expression of target markers, leading to inefficient tumor targeting and contributing to drug resistance and relapse. Therefore, seeking a more universal target is crucial for enhancing drug enric...
Nanoparticles-mediated intratumoral gene editing targeting PD-L1 and Galectin-9 for improved cancer immunotherapy [0.03%]
用于改善癌症免疫治疗的靶向PD-L1和半乳糖凝集素-9的纳米颗粒介导的瘤内基因编辑疗法
Tianxu Fang,Yueyang Deng,Mo Chen et al.
Tianxu Fang et al.
PD-L1, a typical immune checkpoint expressed on tumor cells, reduces the effectiveness of T cell-mediated killing, which is further aggravated by Galectin-9 (Gal-9) co-expression through the TIM3/Gal-9 pathway. Although immune checkpoint in...
Topology scaffolds-enhanced paracrine of BMSCs through mechanotransduction-related metabolism reprogramming for burn wounds healing [0.03%]
基于力学转导相关代谢重编程的拓扑支架增强骨髓间充质干细胞旁分泌促进创面修复
Qingrong Zhang,Jiangfeng Li,Jiezhi Jia et al.
Qingrong Zhang et al.
Paracrine function of mesenchymal stem cells (MSCs) plays the core role in applying for tissue regeneration and repair, which can be enhanced by various strategies. However, the underlying law and mechanism of enhancing paracrine function t...
Engineered exosomes for targeted microRNA delivery to reverse liver fibrosis [0.03%]
工程化外泌体递送microRNA治疗肝纤维化
Huan Zhang,Jianming Xing,Man Sun et al.
Huan Zhang et al.
Despite the widespread use of nucleic acid drugs in liver fibrosis treatment, their therapeutic efficacy remains limited due to challenges in penetrating extracellular matrix (ECM) and effectively targeting activated hepatic stellate cells ...
Personalized NIR-II probes for comprehensive monitoring and evaluation of dialysis vascular access [0.03%]
个性化近红外二区探针全面监测和评估透析通路血管 доступ性
Yanli Cheng,Shengjie Ma,Wei Gong et al.
Yanli Cheng et al.
Vascular access is regarded as the "lifeline" for maintaining hemodialysis in patients with end-stage renal disease (ESRD). An optimal vascular access ensures adequate blood flow, thereby facilitating effective dialysis and enhancing patien...