Mesenchymal stem cell membrane camouflaged mesoporous polydopamine for Parkinson's disease treatment via alleviating oxidative stress mediated neuroinflammation [0.03%]
通过减轻氧化应激介导的神经炎症治疗帕金森病的间充质干细胞膜伪装中孔聚多巴胺体系结构
Yuqin Chen,Wei Lv,Jiangna Xu et al.
Yuqin Chen et al.
Excessive accumulation of reactive oxygen species (ROS) in Parkinson's disease (PD) leads to oxidative stress, which induces neuroinflammation and accelerates disease progression. To address this, we developed mPDA@MSC, a nanosystem consist...
An omics-based drug-HIFU combination therapy discovery for ferroptosis treatment of TNBC [0.03%]
基于组学的药物和HIFU联合治疗用于TNBC铁死亡治疗的新药发现研究
Ruizhe Xu,Xiaomin Su,Xifeng Qin et al.
Ruizhe Xu et al.
Combination therapy, as a vital strategy in cancer treatment, aims to overcome the limitations of monotherapies by combining two or more drugs or treatments to enhance antitumor efficacy. However, the unclear interactions between different ...
Corrigendum to 'Pathology-targeted cell delivery via injectable micro-scaffold capsule mediated by endogenous TGase' [Biomaterials, 126 (2017), 17950] [0.03%]
“利用内源性TGase介导的可注射微支架载体进行病理导向细胞递送”一文的勘误公告
Chunxiao Qi,Yaqian Li,Patrick Badger et al.
Chunxiao Qi et al.
Published Erratum
Biomaterials. 2025 Jul 5:123536. DOI:10.1016/j.biomaterials.2025.123536 2025
Efficient organic nanoparticles for photothermal antibacterial activity and immune regulation to promote maxillofacial wound healing and scarless repair [0.03%]
高效有机纳米颗粒光热抗菌及免疫调节促进颌面伤口愈合和无疤痕修复
Shu Lou,Changyue Xing,Jiarong Zhang et al.
Shu Lou et al.
Treating maxillofacial infections is hindered by severe inflammation and bacterial biofilms, which delay healing and often result in significant scarring. Photothermal therapy (PTT), which utilizes a photothermal agent (PTA) to generate loc...
Epigenetic-targeted biomimetic nanomedicine modulates epithelial mesenchymal transition to enhance chemosensitivity in heterogeneous tumors [0.03%]
表观遗传靶向类生物纳米药物调节异质肿瘤上皮间质转化以增强化学敏感性
Guisong Shan,Wanrong Wang,Xueqian Li et al.
Guisong Shan et al.
Epithelial-mesenchymal transition (EMT) is a key driver of chemoresistance and poor clinical outcomes in cancer. Strategies to reverse EMT-mediated drug resistance and to dynamically monitor treatment response are critical for improving the...
Genetically modified bacterial vesicles with interferon-γ and tumor antigen remodel anti-tumor cellular immunity by modulating dendritic cells [0.03%]
基因工程改造细菌囊泡递送干扰素-γ和肿瘤抗原重编程树突细胞极化抗肿瘤细胞免疫效应
Yuting Fu,Biao Duan,Peng Zheng et al.
Yuting Fu et al.
The tumor vaccine is regarded as a promising immunotherapeutic approach for the treatment of malignant tumors by activating dendritic cell (DC) and eliciting T-cell responses. Toll-like receptor (TLR) ligands are recognized as effective sti...
Piezoelectric polylactic acid-based biomaterials: Fundamentals, challenges and opportunities in medical device design [0.03%]
用于医疗器械设计的压电聚乳酸基生物材料：基础、挑战和机遇
Richard Schönlein,Pravin Bhattarai,Mohammad Raef et al.
Richard Schönlein et al.
Poly(l-lactic acid) (PLLA) has long been identified as a biodegradable, sustainable and biocompatible polymer, with widespread use in a multitude of FDA approved resorbable medical devices. Recently, owing to its piezoelectric properties, P...
Polydopamine nanoparticle-enhanced stem cell spheroid-derived decellularized extracellular matrix with antioxidant and tissue-adhesive properties for brain repair [0.03%]
一种抗氧化和组织粘附的脑修复材料：聚多巴胺纳米粒子增强型干细胞球体去细胞基质
Pei-Ching Yang,Ying-Chi Kao,Yu-Ping Lin et al.
Pei-Ching Yang et al.
The use of implantable biomaterials has emerged as a promising therapeutic strategy for managing traumatic brain injury (TBI). We have previously demonstrated that mesenchymal stem cell (MSC) spheroid-derived three-dimensional decellularize...
A heterogeneous hydrogel patch with mechanical activity and bioactivity for chronic diabetic wound healing [0.03%]
一种用于慢性糖尿病伤口愈合的具有机械活性和生物活性的异质水凝胶贴片
Suyang Dai,Lingchen Mao,Xiongwei Chen et al.
Suyang Dai et al.
Chronic wounds are common complications for diabetic patients, characterized by difficult healing because of the persistent and excessive inflammatory response, susceptibility to infection, and a lack of effective contraction stress at the ...
Disrupting intracellular redox homeostasis through copper-driven dual cell death to induce anti-tumor immunotherapy [0.03%]
铜驱动的双重细胞死亡诱导免疫治疗破坏细胞内氧化还原稳态
Zhenxin Wang,Yuting Li,Congcong Wang et al.
Zhenxin Wang et al.
The abnormality of redox homeostasis within tumors serves as a fundamental driving force for their growth and metastasis. Based on the coordination chemistry of specific metal ions, the precise modulation of intracellular reduction mechanis...