Multi-scale engineering of biodegradable Zn-Mg interbody cages for stronger, faster spinal fusion [0.03%]
用于更强更快脊柱融合的可降解锌镁椎间融合器的多尺度工程设计
Zihuan Yang,Jiang Sun,Chengcong Huang et al.
Zihuan Yang et al.
Spinal interbody fusion cages must be able to bear heavy loads while integrating seamlessly with the surrounding bone. However, the cages currently used in spinal surgery often fall short on both fronts. To meet the multi-faceted requiremen...
Multifunctional theranostic nanocarrier platform for microglia-selective cytochalasin D delivery to modulate neuroinflammation after acute brain injuries [0.03%]
用于选择性递送cytochalasinD以调节急性脑损伤后的神经炎症的多功能治疗诊断纳米载体平台
Sabri E M Sahnoun,Rozina Noristani,Paolo Alimonti et al.
Sabri E M Sahnoun et al.
Targeting microglia to modulate neuroinflammation after acute brain injuries (ABIs) is promising but limited by poor blood-brain barrier (BBB) penetration and systemic toxicity of candidate agents. In addition, multifunctional platforms com...
Oxygen-enriching hollow MOF as nanobubbles to enhance treatment of hypertrophic scar via microneedle-mediated sonodynamic therapy [0.03%]
一种用于微针介导的声动力学治疗肥厚性疤痕的MOF纳米空穴富氧技术
Yixian Mu,Junzhe Fu,Yukun Wang et al.
Yixian Mu et al.
Hypertrophic scars (HS) are characterized by the over-proliferation of hypertrophic scar fibroblasts (HSFbs) and excessive deposition of a dense extracellular matrix (ECM), which collectively restrict the transdermal delivery and intralesio...
A low-crosslinking hydrogel integrating prodrug nanoparticles modulates neuroinflammation and ECM deposition for enhanced spinal cord regeneration [0.03%]
一种低交联水凝胶整合前药纳米颗粒调节神经炎症和细胞外基质沉积以增强脊髓再生
Xianghang Chen,Beini Wang,Jiayan Hui et al.
Xianghang Chen et al.
Spinal cord injury (SCI) causes pathological extracellular matrix (ECM) deposition and tissue stiffening, impeding axonal regeneration and disrupting homeostasis. Galardin-mediated inhibition of matrix metalloproteinases reduces ECM deposit...
Nano-pathogenoids hitchhike activated neutrophils for eliminating of atherosclerosis plaques [0.03%]
纳米病原oid附乗活化中性粒细胞消除动脉粥样硬化斑块
Min Liu,Siyi Liu,Han Yang et al.
Min Liu et al.
Atherosclerosis (AS) is a chronic inflammatory disease characterized by plaques that are difficult to eliminate. Neutrophil extracellular traps (NETs) are a central factor in the progression of AS, which could trigger a cascade of inflammat...
Mucosa-penetrating NIR-II nanomedicine for precision photoimmunotherapy of bladder cancer [0.03%]
用于精确光免疫治疗膀胱癌的穿透黏膜的近红外二区纳米药物
Yuxun Ding,Yiqi Zhu,Jiangao Li et al.
Yuxun Ding et al.
Photoimmunotherapy has emerged as a promising modality in cancer treatment, but its effectiveness is limited by inadequate photoagent delivery and inflammation-induced immunosuppression. Herein, we developed an NIR-II-emitting mucosa-penetr...
A coenzyme-based self-stabilized Janus adhesive patch for spatiotemporal regulation of sutureless diabetic tendon healing [0.03%]
一种基于辅酶的自稳定的Janus粘合贴片，用于时空调节无创糖尿病肌腱修复
Chenguang Ouyang,Zhipeng Ni,Haojie Yu et al.
Chenguang Ouyang et al.
Chronic inflammation and adhesion formation severely impede the healing process of diabetic tendons, while current surgical sutures and pharmacological interventions often fail to restore microenvironmental homeostasis. Here, we report a co...
Polyphosphorylcholine-modified liposomes for glioblastoma-targeted siRNA delivery across the blood-brain barrier [0.03%]
用于跨越血脑屏障靶向递送siRNA治疗胶质母细胞瘤的多聚磷酸胆碱修饰脂质体
Muhammad Ismail,Ningyang Wang,Yundong Li et al.
Muhammad Ismail et al.
Liposomes represent versatile drug delivery shuttles in clinics for cancer therapy. Nevertheless, traditional PEG-modified liposomes encounter difficulties, including (1) poor blood-brain barrier (BBB) transcytosis and tumor targeting witho...
Ultrasound-induced nitric oxide release from isosorbide dinitrate nanoparticles for on-demand therapy of periodontitis [0.03%]
用于按需治疗牙周炎的硝酸异山梨酯纳米颗粒的超声诱导一氧化氮释放疗法
Xinchao Wang,Zhilin Liu,Fengli Wu et al.
Xinchao Wang et al.
Nitric oxide (NO) can effectively combat periodontitis by disrupting biofilms and suppressing inflammation; however, its clinical translation has been limited by the lack of a controllable delivery strategy. This study aimed to develop an u...
An immunomodulatory hydrogel encapsulating dental follicle stem cell-derived small extracellular vesicles promotes neutrophil clearance and periodontal bone regeneration [0.03%]
负载牙囊干细胞来源的小细胞外囊泡的免疫调控型水凝胶促进中性粒细胞清除及牙周骨再生
Maoxue Li,Yuqi Wen,Yi Ding et al.
Maoxue Li et al.
Periodontitis, characterized by progressive alveolar bone resorption and periodontal defect formation, remains a major clinical challenge driven by bacterial infection and a dysregulated inflammatory immune microenvironment. Neutrophils, as...