Swift-acting structured lattice-enhanced caramelized sucrose system for painless sedative delivery [0.03%]
一种速效格子化结构的焦糖化蔗糖系统用于无痛给药
Xinting Liang,Lei Yang,Xiuli Chen et al.
Xinting Liang et al.
Dexmedetomidine, known as an exceptionally potent and highly selective α2-adrenergic receptor agonist, is widely used as a safe and effective intravenous sedative agent in both surgical and nonsurgical settings. As the need for an optimize...
Corrigendum to "An antioxidative injectable chitosan hydrogel based on tannic acid modified dialdehyde polyurethane nano-crosslinker targeting RIPK1 to regulate neuroinflammation for amelioration of Parkinson's disease" [Biomaterials, 325 (2026), 123614] [0.03%]
关于“基于鞣花酸改性二醛聚氨酯纳米交联剂的抗氧化性壳聚糖水凝胶靶向RIPK1调节神经炎症以改善帕金森病”的勘误[Biomaterials, 325 (2026), 123614]
Junpeng Xu,Chaohui Guo,Guangshuai Zhou et al.
Junpeng Xu et al.
Published Erratum
Biomaterials. 2025 Nov 13:123842. DOI:10.1016/j.biomaterials.2025.123842 2025
Chemo-immunotherapeutic potential of Lactobacillus rhamnosus GG and its bioengineering for cancer therapy [0.03%]
乳酸菌GG的化学免疫治疗潜力及其生物工程技术在癌症治疗中的应用
Zhaonan Liu,Qing Guan,Jianfeng Xin et al.
Zhaonan Liu et al.
Bacteriotherapy holds great promise for cancer treatment, yet few bacterial agents have progressed to clinical application. Inspired by the acidic growth conditions of Lactobacillus rhamnosus GG (LGG), which resemble the tumor microenvironm...
Pro-osteogenic implants inhibit local excessive B cell maturation via neutrophils-derived CD52 signaling to enhance osseointegration [0.03%]
促成骨植入物通过中性粒细胞来源的CD52信号抑制局部过度B细胞成熟以增强骨整合
Yangbo Xu,Congrui Zhao,Jingyao Gong et al.
Yangbo Xu et al.
Metallic implants have been widely utilized in orthopedics surgery. Osseointegration is a local tradeoff between the inflammatory microenvironment and repair processes surrounding implants, driven by innate and adaptive immune cells. B cell...
Biomimetically anisotropic hierarchical scaffold mediating stress transmission along the direction of force loading for rapid bone regeneration [0.03%]
用于快速骨再生的生物力学分级支架沿着受力方向传递应力
Yan-Lin Wu,Liu-Yan Huang,Lin Liu et al.
Yan-Lin Wu et al.
The mechanical conduction of artificial bone scaffolds, predominantly governed by the scaffold structure, significantly influences their osteogenic capacity. Although various meticulously designed scaffold structures can enhance the osteoge...
Sericin-based dual-module microspheres promote periodontal regeneration through four-dimensional microenvironment remodeling [0.03%]
丝素蛋白基四维微环境调控的双模块微球促进牙周组织再生诱导修复
Peirong Zhou,Xuemin Ma,Yajuan Hu et al.
Peirong Zhou et al.
Periodontitis, a chronic inflammatory disease marked by oxidative stress, dysregulated inflammation, and alveolar bone resorption, remains a major oral health challenge due to conventional therapy's limited spatiotemporal control over tissu...
Nerve growth factor-targeting nanocluster-antibody-drug conjugates for intravesical precision theranostics of interstitial cystitis [0.03%]
针对神经生长因子的纳米聚集体抗体药物偶联物用于间质性膀胱炎的腔内精准诊疗
Zhijun Lin,Wanyan Wang,Dingxin Liu et al.
Zhijun Lin et al.
Interstitial cystitis (IC) is a chronic inflammatory bladder disorder lacking timely diagnostic and therapeutic options. Here, we propose a unitary theranostic nanocluster-antibody-drug conjugate (NADC) by covalently attaching dihydroorotat...
Platelet concentrate-derived extracellular vesicles promote adult hippocampal neurogenesis [0.03%]
血小板衍生的外泌体促进成人海马神经发生
Ariunjargal NyamErdene,Nhi Thao Ngoc Le,Ouada Nebie et al.
Ariunjargal NyamErdene et al.
Platelet-derived materials are emerging as promising, cell-free biotherapies for regenerative medicine. While platelet lysates have shown neuroprotective activity in preclinical models, the neurogenic potential of platelet concentrate-deriv...
Biomimetic nanoplatform-mediated CRISPR/Cas9 delivery for dual-pathway metabolic blockade in head and neck squamous cell carcinoma [0.03%]
仿生纳米平台介导的CRISPR / Cas9递送用于头颈鳞状细胞癌的代谢双通道阻断
Ting Fang,Chang Peng,Rui Ding et al.
Ting Fang et al.
Head and neck squamous cell carcinoma (HNSCC) continues to exhibit a poor prognosis, largely due to late diagnosis and the development of cisplatin resistance. Tumor proliferation in HNSCC is closely associated with upregulation of key glyc...
Mo2C nanozyme targets citrate synthase to treat acute kidney injury through alleviating oxidative stress and dysfunction of energy metabolism [0.03%]
Mo2C纳米酶靶向柠檬酸合酶治疗急性肾损伤通过缓解氧化应激和能量代谢障碍
Wei Wei,Yuyi Zhu,Xiaoqin Shui et al.
Wei Wei et al.
Acute kidney injury (AKI), characterized by rapid renal dysfunction, lacks effective therapies due to its complex pathophysiology involving oxidative stress and mitochondrial damage. Molybdenum carbide (Mo2C) nanozymes show promise through ...