Laser-facilitated peroxidase-like hydrogel with simultaneous wound infection monitoring and eliminating [0.03%]
一种激光活化过氧化物模拟水凝胶用于同时监测和消除伤口感染
Zhibin Li,Guangtao Huang,Xiangqiang Dai et al.
Zhibin Li et al.
Clinically, despite tremendous efforts having been devoted to preventing the invasive bacterial infection in acute and chronic wounds, the abuse or excessive use of antibacterial agents still poses great hurdles for wound management, which ...
Mimicking gingival endotoxin tolerance to modulate immune balance for tumor postoperative wound management [0.03%]
模仿龈沟内毒素耐受以调节免疫平衡管理肿瘤术后伤口炎症微环境
Daping Xie,Zhencheng Liao,Chonghao Chen et al.
Daping Xie et al.
Postoperative management after tumor resection poses a significant clinical challenge as it must satisfy two demands - tumor eradication and tissue repair, which require contradictory immunological characteristics. Current treatment strateg...
Genetically engineering cells to produce therapeutically boosted extracellular vesicles for cardiovascular calcification [0.03%]
基因工程细胞产生具有治疗作用的细胞外囊泡以用于心血管钙化
Neil Patel,Veronica LaMastro,Joshua Giblin et al.
Neil Patel et al.
Calcification associated with atherosclerosis is a major driver of morbidity globally. Despite the correlation of calcification with plaque rupture and sudden death, there are no clinically approved therapies that treat vascular calcificati...
Contactless 3D acoustic assembly of liquid capsules for bottom-up tissue engineering [0.03%]
用于自下而上组织工程的液滴微流控组装技术
Maria Eduarda Rocha Luiz,Mariana Carreira,Sara Nadine et al.
Maria Eduarda Rocha Luiz et al.
In recent years, considerable efforts have been directed towards developing systems that replicate native tissue microarchitecture, enhancing cell viability and achieving close-to-native cellular organization. Despite advancements in variou...
EGCG-releasing nanofibrous scaffold enhances wound healing via γδ T cells modulation [0.03%]
表没食子儿茶素没食子酸酯释放型纳米纤维支架通过调节γδT细胞改善伤口愈合
Tiantian An,Zhaoyu Xu,Yang Yang et al.
Tiantian An et al.
This study investigates the role of γδ T cells in wound healing facilitated by an EGCG (Epigallocatechin gallate)-releasing nanofibrous scaffold with aligned topography (APEMS). Incorporating core-shell microcapsules for sustained EGCG re...
Inhalable micro/nanoparticles for pulmonary delivery of macromolecular therapeutics: A review [0.03%]
用于肺递送大分子治疗剂的可吸入微/纳米颗粒：综述
Songpei Xie,Niloofar Fatemipayam,Jing Zhang et al.
Songpei Xie et al.
Direct delivery of macromolecules to the lungs will lead to new treatments for pulmonary diseases that are currently debilitating for millions of people all over the world. These approaches will enable novel gene therapy treatments as well ...
Lactate metabolism regulating nanosystem synergizes cuproptosis and ferroptosis to enhance cancer immunotherapy [0.03%]
调控乳酸代谢的纳米系统协同铜死亡和铁死亡增强癌症免疫治疗
Hui Zhi,Weimin Yin,Shiyu Chen et al.
Hui Zhi et al.
Cuproptosis and ferroptosis exhibit superior synergistic advantages in antitumor therapy. While glutathione (GSH) has been identified as a key molecule in enhancing the synergistic effects of these two processes, inherent cellular redox hom...
Biodegradable hollow MnO2 decorated by carbon dots with cholesterol depletion capability for cascaded amplification of sono-immunotherapy [0.03%]
一种可生物降解的空心锰 dioxide@碳点纳米材料及其在免疫治疗中的应用
Jingru Zhao,Jinming Cai,Jinyan Hu et al.
Jingru Zhao et al.
For the effective activation of the adaptive immune response, it is crucial to promote the maturation of dendritic cells (DCs) and subsequently initiate cytotoxic T lymphocytes. Nevertheless, the immunosuppressive tumor microenvironments (T...
Photoinitiated CVD antifouling coatings enable long-term stability of flexible multifunctional neural probes for chronic neural recording [0.03%]
光引发CVD防污涂层使柔性多功能神经探针长期记录慢性神经信号成为可能
Yunyoung Choi,Woojin Jeon,Yeji Kim et al.
Yunyoung Choi et al.
Flexible neural probes with integrated recording, optical stimulation, and drug delivery capabilities offer unprecedented access to neural circuit dynamics. However, their long-term utility is compromised by foreign body responses that isol...
Translational contrast agents for use in fluorescence image-guided tumor surgery [0.03%]
用于荧光图像引导肿瘤手术的影像对比剂
Da-Yong Hou,Xiang-Peng Li,Yue-Ze Wang et al.
Da-Yong Hou et al.
Currently, surgical intervention remains the foundation in curing most solid tumors. Over the past few decades, even with rapid intraoperative tissue pathology assessment, the overall rate of positive surgical margins for tumors stagnated b...