Intestinal therapeutic agent delivery microrobot with magnetic targeting and pH-triggered degradation abilities [0.03%]
一种具有磁靶向和pH响应性降解能力的肠道治疗机器人
Hyoryong Lee,Na Eun Mun,Deockhee Yoon et al.
Hyoryong Lee et al.
Oral drug delivery remains a clinically preferred route for colorectal cancer therapy due to its noninvasive nature and patient compliance. However, conventional formulations suffer from premature degradation in the gastric environment and ...
Therapeutic mitochondrial transfer via mesenchymal stem cell-derived microvesicles for macrophage modulation in myocardial infarction complicated by diabetes [0.03%]
糖尿病合并心肌梗死微环境中间充质干细胞来源的微泡通过治疗性线粒体转移调节巨噬细胞极化的作用及机制研究
Zixuan Dong,Song Liu,Xiaobing Liu et al.
Zixuan Dong et al.
Diabetes is closely associated with the onset and prognosis of myocardial infarction (MI). However, current treatment strategies primarily focus on addressing MI, often neglecting the detrimental effects of hyperglycemia, a hallmark of diab...
Enzyme-responsive biomimetic ferritin nanoparticles for selective cancer therapy [0.03%]
一种酶响应型仿生铁蛋白纳米粒子的癌症选择性治疗研究
Xiaohan Hao,Hao Zhang,Yuzhao Yang et al.
Xiaohan Hao et al.
Plasma membrane rupture offers promising potential for cancer therapy by physically disrupting cell membranes. However, its clinical use is limited by non-selective cytotoxicity, particularly hemolysis, during systemic administration. Here,...
Self-assembled copper-amino acid nanoleaves for targeted treatment of deep-seated bacterial infections via chemodynamic therapy and cuproptosis-like death [0.03%]
自组装铜-氨基酸纳米叶片通过化学动力学治疗和类铜死亡作用治疗深部细菌感染
Yutong Li,Yuhang Li,Haojie Chen et al.
Yutong Li et al.
Transition metal ions such as Cu2+ are promising broad-spectrum bactericidal agents. However, transition metal ions are not used to treat deep-seated bacterial infections in clinic owing to easy deactivation by proteins and lack of targetin...
Tenascin-c functionalised self-assembling peptide hydrogels for critical-sized bone defect reconstruction [0.03%]
用于骨缺损重建的tenascin-c功能化自组装肽水凝胶
Alexandre Trubert-Paneli,Jonathan A Williams,James F C Windmill et al.
Alexandre Trubert-Paneli et al.
Critical-sized bone defects cannot heal spontaneously and receive poor clinical prognosis due to limitations in modern treatment strategies. Next-generation therapies are applying biomaterials incorporating BMP-2 to effectively promote and ...
Hydrogel/nano-immunostimulant composite mitigates surgery-exacerbated immunosuppression for durable postsurgical adjuvant treatment of high-propensity lymph node-metastatic tumors [0.03%]
水凝胶/纳米免疫刺激物复合材料可缓解手术加剧的免疫抑制，从而持久地治疗高淋巴结转移倾向性肿瘤术后辅助治疗
Peiying Huang,Sijin Chen,Xinru Huang et al.
Peiying Huang et al.
The development of effective postsurgical adjuvant treatments for tumors, particularly high-propensity lymph node-metastatic tumors (LNMTs), remains a significant challenge. Our study elucidates the critical role of surgery in exacerbating ...
Nitric oxide-driven copper homeostasis and osteogenesis in cranial defect regeneration using l-arginine-loaded HKUST-1 [0.03%]
L-精氨酸负载的HKUST-1介导一氧化氮调控铜离子稳态促进颅骨缺损再生修复中的成骨作用
Feng Zhou,Zhaoyu Xu,Qingyi Wang et al.
Feng Zhou et al.
Copper plays a multifaceted role in bone tissue engineering, including regulating osteogenic and chondrogenic differentiation, exhibiting antibacterial activity, and enhancing mechanical properties. However, excessive copper induces a disti...
MXenzyme-reinforced hydrogel enhances stem cell therapy through multidimensional regulation in rheumatoid arthritis management [0.03%]
MX酶增强的水凝胶通过多维度调节提升干细胞疗法在类风湿关节炎管理中的效果
Yue Zhao,Zuhao Li,Xiao Chen et al.
Yue Zhao et al.
Rheumatoid arthritis (RA) is a devastating autoimmune disorder that imposes health and economic burdens on communities worldwide. Although stem cell transplantation has emerged as a promising option for RA management, the osteoimmune microe...
Chrono-controlled hydrogel platform orchestrates metabolic reprogramming and cuproptosis-driven immune activation against triple-negative breast cancer [0.03%]
基于时间控制的水凝胶平台通过代谢重编程和铜死亡驱动的免疫激活对抗三阴性乳腺癌
Yao Lu,Qingqing Pan,Kui Luo et al.
Yao Lu et al.
Triple-negative breast cancer (TNBC) poses significant therapeutic challenges due to its metabolic plasticity and immunosuppressive microenvironment. In this study, we present a sequential drug release hydrogel system (SeqGel) that reprogra...
Reversible shear stress-mediated mechanoregulation of endothelial cell function in thixotropic hydrogels via L-type Ca2+ channel and focal adhesion molecules for accelerated vascularization [0.03%]
可逆的剪切应力介导的类凝胶流体中内皮细胞功能的力学调节通过L型Ca2+通道和粘着斑分子加速血管化
Zhongtao Li,Sumei Li,Rongwei Cui et al.
Zhongtao Li et al.
Developing functional vascular networks in engineered tissues is crucial for regenerative medicine. Recently, thixotropic hydrogel has emerged as a promising approach due to their 3D-printability and force-responsive dynamics. However, thei...