Hydroxyl-augmented gold nanorods via lactone ring-opening alleviate cisplatin nephrotoxicity through Nrf2 activation [0.03%]
富羟基金纳米棒通过开环乳酸根减轻顺铂肾毒性的Nrf2激活机制研究
Chunyan Fang,Yueming Cai,Cui He et al.
Chunyan Fang et al.
Cisplatin-induced acute kidney injury (AKI) epitomizes a critical barrier and paradox in cancers, where dose-limiting nephrotoxicity propelled by oxidative cascades lacks targeted interventions. This pressing clinical dilemma underscores th...
Engineered peripheral CD4 T cells delivery across the BBB promote intracerebral Treg conversion unleashes microglial phagocytotic activity for Alzheimer's disease treatment [0.03%]
工程化外周CD4 T细胞通过血脑屏障递送促进颅内Treg转化释放小胶质噬菌活性治疗阿尔茨海默病
Zejie Zuo,Zecong Xiao,Liying Zhang et al.
Zejie Zuo et al.
Alzheimer's disease (AD) affects thirty million individuals worldwide, but a viable treatment has yet to be identified. During disease progression, peripheral immune cells, including peripheral T cells, infiltrate the brain. Although CD4+ r...
Metabolic small molecules materialized hydrogel promotes diabetic bone regeneration through osteoimmunological remodeling [0.03%]
代谢小分子交联的水凝胶通过骨免疫学重塑促进糖尿病骨再生
Qun Li,Ke Xu,Jia Li et al.
Qun Li et al.
The clinical repair of diabetic jawbone defects is still yet challenging because of chronic inflammation and dysregulation in metabolism. Metabolic small molecule alpha-ketoglutarate (αKG) and D-mannose displayed promising bone homeostasis...
SARS-CoV-2 inhibition through mRNA delivery using engineered extracellular vesicles displaying the spike protein [0.03%]
利用工程化细胞外囊泡展示刺突蛋白的mRNA传递抑制SARS-CoV-2
Yuna Nakagawa,Yoshimasa Kawaguchi,Hisaaki Hirose et al.
Yuna Nakagawa et al.
Coronavirus disease (COVID-19) caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), has been the biggest pandemic in recent years, and there is a growing demand for the development of new modalities to treat emerging infections ra...
A microsphere-vesicle hybrid system for tumor treatment through enhancement of innate and adaptive immune responses [0.03%]
一种微球-囊泡混合系统通过增强先天性和适应性免疫反应来进行肿瘤治疗
Yida Chen,Xinyi Cheng,Can Zhu et al.
Yida Chen et al.
Cancer immunotherapies, designed to modulate innate and/or adaptive immune responses alongside targeting immune checkpoint pathways, are hindered by the immunosuppressive properties of the tumor microenvironment (TME). In the present study,...
Core-shell structured CeO2@ZIF-8 nanohybrids regulating the Ce(III)/Ce(IV) valence conversion to enhance ROS-scavenging capacity for periodontitis treatment [0.03%]
用于调节CeO₂@ZIF-8核壳纳米杂化材料中Ce(Ⅲ)/Ce(Ⅳ)价态转换以提升ROS清除能力治疗牙周炎研究
Yameng Yu,Xiwen Zhao,Yufeng Zheng et al.
Yameng Yu et al.
Colonization of pathogenic microorganism is the initiating factor of periodontitis, inflammatory-induced imbalance of reductant-oxidant homeostasis is the leading cause of alveolar bone defects. Herein, core-shell structured nanohybrids wit...
Charge-reversal nanoassembly for rheumatoid arthritis therapy via cell-free DNA scavenging and microenvironment reprogramming [0.03%]
基于无细胞DNA清除和微环境重编程的抗类风湿关节炎正负电中和纳米制剂
Chang Peng,Ting Fang,Hanjie Sun et al.
Chang Peng et al.
The clearance of cell-free DNA (cfDNA) in rheumatoid arthritis (RA) represents a promising therapeutic approach for inflammation. While cationic materials are widely utilized for cfDNA capture, their safety during in vivo delivery remains a...
Lipid nanoparticle-mediated delivery of microRNA-124 reduces neuroinflammation [0.03%]
脂质纳米颗粒介导的微小RNA-124传递可降低神经炎症水平
Zhanjun Ma,Hong Anh Dang,Jingjing Yang et al.
Zhanjun Ma et al.
MicroRNAs (miRNAs) regulate many physiological and pathological processes implicated in numerous diseases, including neuroinflammatory disorders. Chronic neuroinflammation is a key feature of neurodegenerative diseases, yet effective medica...
Self-adaptive covalent coating for vascular stents: Coordinated coagulation-inflammation regulation to support re-endothelialization for atherosclerosis control [0.03%]
自适应共价涂层血管内支架：协调凝血-炎症调节促进再内皮化以控制动脉粥样硬化
Yanan Wang,Qiongjun Zhu,Zhezhe Chen et al.
Yanan Wang et al.
Therapeutic-coated vascular stents are one of the key directions in the clinical treatment of atherosclerosis. However, vascular injury and implant stimulation trigger a feedback loop between coagulation and inflammation, impairing endothel...
Microliter-scale ethanol confinement array with biofluidic triggered release for dual-enhanced precision chemotherapy [0.03%]
一种基于生物流体触发释放微升级乙醇限域阵列的精准化疗增强方法
Tianyue Ma,Fei Zhang,Yumeng Pan et al.
Tianyue Ma et al.
Ethanol is a low-cost, water-insoluble solubilizer for chemotherapeutics and a tumor ablator in various clinical settings. Three-dimensional (3D) precise control over the flow path of liquid formulations during treatment is crucial for accu...