A sprayable TQ/Ce6@SAB/F-gel for accelerating wound healing via hypoxia-tolerant photodynamic therapy and immune-metabolic pathway [0.03%]
一种喷雾型TQ/Ce6@SAB/F-凝胶，通过耐缺氧光动力疗法和免疫代谢途径加速伤口愈合
Ming Li,Shengzhe Zhou,Qiang Yu et al.
Ming Li et al.
Chronic diabetic wounds are characterized by hypoxia, persistent microbial infection, and impaired healing, posing significant challenges to conventional therapies. Herein, we present a novel sprayable double-network hydrogel platform desig...
Local release of fibroblast growth factor 21 and cannabidiol promoting spinal cord nerve injury repair through activation of cannabinoid receptor 2 [0.03%]
局部释放成纤维细胞生长因子21和大麻二酚通过激活 cannabinoid 受体2促进脊髓神经损伤修复
Zhao Zhang,Zhengquan Wang,Zhihao Shen et al.
Zhao Zhang et al.
Spinal cord injury (SCI) is a debilitating condition that leads to severe motor and sensory dysfunction, largely due to inflammation, neuronal damage, and disrupted neural circuits. In this study, we developed an injectable hydrogel (C/F/Ge...
Enhanced osteointegration of implants in aged rats via a stem cell pool aging reversion strategy [0.03%]
通过干细胞池衰老逆转策略增强植入体在老年大鼠中的骨整合能力
Xuan Li,Xinxin Luo,Ye He et al.
Xuan Li et al.
The senescence of mesenchymal stem cells (MSCs) leads to the significant change of their metabolic activity and physiological behaviors. In the context of orthopedic treatment, the osteointegration of titanium implant is largely affected by...
Copper metal-organic framework-based multifaceted strategy for boosting cancer therapy via synergistic cuproptosis and disulfidptosis [0.03%]
一种基于铜金属有机骨架的多方位策略通过协同促进癌症治疗
Zede Wu,Mengdan Gao,Qiuyu Li et al.
Zede Wu et al.
Cuproptosis, a form of copper-dependent programmed cell death, has emerged as a promising therapeutic target for cancer treatment. However, the efficacy of cuproptosis is undermined by metabolic reprogramming, notably the Warburg effect and...
Self-supported DNA hydrogel facilitates microenvironment remodeling and cartilage repair to prevent osteoarthritis progression via an ambidextrous strategy [0.03%]
自支撑DNA水凝胶通过双管齐下的策略重塑微环境并修复软骨以预防骨关节炎进展
Yixin Liu,Xinjian Yang,Ya Miao et al.
Yixin Liu et al.
Osteoarthritis (OA), a prevalent degenerative joint disease, currently lacks effective therapeutic options beyond symptomatic relief. Persistent inflammation and impaired cartilage repair accelerate the disease progression. The enzyme induc...
Temporary silk nanocoatings preserve immune cell functions and protection against biochemical and mechanical stressors [0.03%]
丝蛋白纳米涂层可保护免疫细胞免受化学、有害生物和机械刺激的影响并保持其功能
Udathari Kumarasinghe,Nilotpal Majumder,Julian M Sutaria et al.
Udathari Kumarasinghe et al.
Cell-based therapies offer transformative potential for treating a range of diseases, however, maintaining desirable cell functions under environmental and biochemical stresses remains a major challenge. In the present study, silk ionomer n...
Cancer-associated fibroblasts regulating nanomedicine to overcome sorafenib resistance in hepatocellular carcinoma with portal vein tumor thrombus [0.03%]
癌相关成纤维细胞介导的纳米药物调节克服门静脉瘤栓肝癌索拉非尼耐药性研究
Lin Zhu,Mali Zu,Feifan Wu et al.
Lin Zhu et al.
Portal vein tumor thrombus (PVTT) is a common and severe indicator in advanced hepatocellular carcinoma (HCC), characterized by a poor prognosis and limited response to existing therapies. Cancer-associated fibroblasts (CAFs) play an import...
OH-optimized rational design of binary phytochemical hydrogels to combat multidrug-resistant fungal infections via CWI-MAPK pathway modulation [0.03%]
通过CWI-MAPK途径调节优化合理设计二元植物化学凝胶对抗多重耐药真菌感染
Shuchang Yao,Qi Han,Xuemei Huang et al.
Shuchang Yao et al.
The unique design of low molecular weight hydrogels (LMWH) without carriers has sparked great interest in biomedical applications, yet the construction of binary LMWH remains elusive due to the lack of a theoretical framework linking struct...
Natural coagulation inspired RBCs-structural inheritance microgels hybrid featured with quasi-bicontinuous structure for junctional hemostasis [0.03%]
受自然凝血启发的红细胞结构遗传微凝胶及其类双连续结构的止血性能研究
Weijun Ji,Mengjie Dou,Henan Ma et al.
Weijun Ji et al.
Junctional hemorrhage is a major prehospital care challenge, causing 67 % of preventable deaths. In addition, the high risk of secondary hemorrhage during transportation remains a challenge for long-term wound protection. Present hemostatic...
Marine-tolerant bioadhesive gel with hydrophobic microdomain-multicrosslinked network for seawater-immersed wound management [0.03%]
一种具有疏水微区-多交联网络的海洋耐受性生物粘附凝胶，用于海水浸泡伤口管理
Mingyu Yu,Xianglong Zhong,Wanting Zhang et al.
Mingyu Yu et al.
Current gel dressings face significant challenges in seawater-immersed wound management due to their marine-intolerance, poor bioadhesion and non-antibacterial properties. Herein, we develop a multifunctional gel that integrates marine-tole...