Endogenous macrophages as "Trojan horses" for targeted oral delivery of mRNA-encoded cytokines in tumor microenvironment immunotherapy [0.03%]
内源性巨噬细胞作为口服递送针对肿瘤微环境免疫治疗的mRNA编码细胞因子的“特洛伊木马”
Po-Kai Luo,Wan-An Chang,Sheng-Yao Peng et al.
Po-Kai Luo et al.
Macrophages (MΦ) in the tumor microenvironment (TME) are often skewed toward the M2 phenotype, which suppresses immune responses and supports tumor progression. Interferon-γ (IFN-γ) plays a pivotal role in reprogramming MΦ toward a pro-...
Multimodal cascade-amplified phototheranostics for enhanced anti-tumor immunity [0.03%]
用于增强抗肿瘤免疫的多模态级联放大光诊疗系统
Liang Chen,Jierou Huang,Li Liu et al.
Liang Chen et al.
Effective immuno-photodynamic therapy (IPDT) is impeded by the limitations of monotherapy approaches, inadequate immune activation, and an immunosuppressive tumor microenvironment (TME). Here, we present a multifunctional phototheranostic n...
MiR-138 reprograms dental pulp stem cells into GABAergic neurons via the GATAD2B/MTA3/WNTs axis for stroke treatment [0.03%]
微RNA-138通过GATAD2B/MTA3/WNTs轴将牙髓干细胞重编程为γ-氨基丁酸能神经元以治疗卒中
Heng Zhou,Ping Wen,Ye Liu et al.
Heng Zhou et al.
Prolonged periods of ischemia and hypoxia pose significant challenges to exogenous stem cell transplantation, including minimal cell survival, varied differentiation, and poor integration with existing neural networks. Dental pulp stem cell...
A novel Kupffer cell-targeting nanoparticle system to Mitigate alcohol-associated liver disease [0.03%]
一种新型的靶向 kupffer 细胞的纳米药物系统可缓解酒精相关性肝病
Janitha M Unagolla,Riley Flanagan,Kalindu Perera et al.
Janitha M Unagolla et al.
Alcohol-associated liver disease (ALD) is a major cause of cirrhosis-related deaths worldwide. Due to its asymptomatic progression, early diagnosis and treatment are challenging, often resulting in severe complications. To address challenge...
Cancer vaccines: Discovery, development, and challenges for clinical translation [0.03%]
癌症疫苗的研发、发展及其临床转化挑战
Zhongkun Zhang,Siyu Yao,Yufei Wang et al.
Zhongkun Zhang et al.
Cancer vaccines stimulate antitumor immunity by delivering tumor antigens and, in recent years, have emerged as a promising therapeutic strategy against cancer. The recent success of mRNA-based cancer vaccines from Moderna in treating patie...
Jian Wang,Fuxiao Wang,Yingying Jiang et al.
Jian Wang et al.
The integration of organoid models with nanomedicine delivery systems offers a novel approach to drug discovery and personalized medicine by enabling more accurate, efficient, and physiologically relevant evaluation of therapeutic efficacy....
Neutrophil-inspired CRISPR/dCas9 nanomedicine to program self-destructing and bystander killing of tumor cell for selective cancer therapy [0.03%]
类中性粒细胞启发的CRISPR/dCas9纳米药物编程肿瘤细胞靶向的智能治疗及杀伤体系用于精准癌症治疗
Hao Li,Xingke Tang,Fangzheng Li et al.
Hao Li et al.
Achieving high efficiency, selectivity, and durability remains a major challenge in the development of innovative cancer treatments, as current clinical therapies often fall short. Inspired by neutrophil-mediated tumor clearance, we enginee...
Natural lignocellulose fibers-based bio-dressing for accelerated wound healing and machine learning-assisted smart multimodal sensing [0.03%]
基于天然木质纤维素的生物敷料促进伤口愈合及机器学习辅助智能多模态传感
Chao Li,Jian Du,Lingyu Zhu et al.
Chao Li et al.
The integration of ultrasensitive smart human-machine interaction and well skin-like healing capabilities into the biomaterials-based dressing still remains great challenges. Herein, a sort of novel multifunctional lignocellulose dressing i...
Clicktetrazine dECM-alginate hydrogels for injectable, mechanically mimetic, and biologically active vocal fold biomaterials [0.03%]
用于声带生物材料的可注射、机械模拟和生物活性点击四嗪dECM-海藻酸水凝胶
Mika Brown,Hideaki Okuyama,Ling Li et al.
Mika Brown et al.
Current injectable biomaterials for vocal fold disorders suffer from fast degradation and require frequent re-injection. Decellularized extracellular matrix (dECM) hydrogels are a tissue-derived, injectable biomaterial with intrinsic regene...
Polyurea-based multimodal interaction nanogels for synergistic bacterial biofilm eradication and prevention of re-colonization [0.03%]
聚脲基多模态交互纳米凝胶用于协同消除细菌生物膜及防止重新定植
Honglin Li,Yanwen Feng,Bingyan Lin et al.
Honglin Li et al.
Bacterial biofilm eradication and prevention of re-colonization are critical for effective treatment of biofilm-associated infections. Although significant progress has been made in nanovehicle-assisted antimicrobial platforms for biofilm e...