Empowering single-cell analysis with emerging active microfluidic devices [0.03%]
新兴的主动微流体设备在单细胞分析中的应用
Qingyu Ruan,Wenshang Guo,Ruizhe Yang et al.
Qingyu Ruan et al.
Understanding cellular heterogeneity is crucial for deciphering infection mechanisms, disease progression, and identifying novel biomarkers for personalized therapies, which provides valuable insights into biological processes and supports ...
Biomimetic artificial bone marrow niches for the scale up of hematopoietic stem and progenitor cells [0.03%]
仿生人工骨髓微环境体系的构建及其对造血干细胞和祖细胞的大规模扩增性能研究
Minerva Bosch-Fortea,Daniele Marciano,Julien E Gautrot
Minerva Bosch-Fortea
Hematopoietic stem cell (HSC) transplantation to treat haematological disorders is greatly restricted by poor cell availability. Engineering of culture platforms that mimic the physiological properties of the bone marrow (BM) in a scalable ...
Adaptive cationic peptide bundles hydrogel for the repair of infected mandibular defects [0.03%]
自适应阳离子肽束水凝胶的构建及其修复感染性下颌骨缺损的功能研究
Yimin Sun,Xuetao Yang,Yin Liu et al.
Yimin Sun et al.
Due to bacterial resistance and the limited self-healing capacity, the treatment of infected mandibular defects remains great challenges. Cationic peptide bundles can kill bacteria more efficiently than the linear ones. However, they are ha...
Mitocytosis-inducing nanoparticles alleviate gemcitabine resistance via dual disruption of pyrimidine synthesis and redox homeostasis in pancreatic ductal adenocarcinoma [0.03%]
线粒体靶向诱导细胞自噬的纳米颗粒通过双重抑制嘧啶合成和氧化还原稳态缓解胰腺导管腺癌吉西他滨耐药性
Yu Wang,Hongrui Fan,Qinjun Chen et al.
Yu Wang et al.
Metabolic reprogramming in pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge to the efficacy of gemcitabine-based chemotherapy. Aberrant activation of intracellular pyrimidine metabolism is a key factor contributing to t...
A metallic metabolic nano-regulator reprograms the PKM2/HIF-1α/DLAT axis to amplify tumor-specific cuproptosis [0.03%]
一种金属代谢纳米调节剂重编程PKM2/HIF-1α/DLAT轴以放大肿瘤特异性铜死亡
Xue Zhan,Hang Xiao,Xuelian Zhang et al.
Xue Zhan et al.
Cuproptosis represents a novel form of mitochondria-dependent cell death, demonstrating a unique antitumor potential. However, tumor cells have evolved robust metabolic compensation mechanisms that mitigate the cytotoxic effects of copper i...
Modulating the oral microbiome with dental biomaterials: A review of challenges, advances, and future perspectives [0.03%]
口腔微生物组的调控：挑战、进展与未来展望
Woojin Choi,Jinkee Hong
Woojin Choi
The oral microbiome plays a pivotal role in maintaining both oral and systemic health. Recent studies highlight the potential of dental biomaterials to modulate this complex microbial community. Because of the short retention time imposed b...
An antioxidative injectable chitosan hydrogel based on tannic acid modified dialdehyde polyurethane nano-crosslinker targeting RIPK1 to regulate neuroinflammation for amelioration of Parkinson's disease [0.03%]
一种抗氧化壳聚糖水凝胶，基于五倍子酸修饰的二醛聚氨酯纳米交联剂，针对RIPK1调节神经炎症以改善帕金森病
Junpeng Xu,Chaohui Guo,Guangshuai Zhou et al.
Junpeng Xu et al.
Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases. Currently, the treatment of PD is mainly based on surgery and medication, and there is a pressing necessity to develop a new generation of strategies...
A novel cell-free regenerative therapy for hair loss: human fetal cartilage progenitor cell secretome [0.03%]
一种用于脱发的新型无细胞再生疗法：人胎盘软骨祖细胞分泌组
Ngoc-Trinh Tran,Minh-Dung Truong,Hee-Woong Yun et al.
Ngoc-Trinh Tran et al.
Hair loss, particularly androgenic alopecia, is driven by testosterone-induced apoptosis and impaired dermal papilla (DP) cell function, disrupting epithelial-mesenchymal interactions and hindering hair follicle regeneration. Current non-su...
Bioactive prosthetic interface constructed with cascading multi-nanozyme hydrogel to induce M2 macrophage polarization and heal diabetic bone defects [0.03%]
用于诱导M2型巨噬细胞极化和修复糖尿病骨缺损的级联多纳米酶水凝胶生物活性假体界面
Dan Li,Zhen Ai,Yujia Tian et al.
Dan Li et al.
Chronic oxidative stress and inflammation in diabetic microenvironments impede the healing of bone defects. Inflammation is prolonged by the decreased phenotypic transformation of M1 to M2 anti-inflammatory macrophages. To achieve catalytic...
Self-assembling heterodimeric prodrug nanoparticles for dual-targeted cancer therapy via the disruption of redox homeostasis and Pin1 degradation [0.03%]
通过破坏氧化还原平衡和Pin1降解进行双重靶向癌症治疗的异二聚体前药纳米粒子的自我组装
Seunga Lee,Suyeon Lee,Sujin Kim et al.
Seunga Lee et al.
Disrupting redox balance by elevating reactive oxygen species (ROS) selectively induces cancer cell death while sparing healthy tissues. Peptidyl-prolyl isomerase (Pin1) is overexpressed in several cancer cells and plays a critical role in ...