Biomimetic epiphysis inspired by natural developmental mechanisms promote the repair of large-scale epiphyseal defects [0.03%]
受自然发育机制启发的仿生软骨生长区促进大型软骨生长区缺陷修复
Pengzhen Cheng,Meige Han,Qingda Lu et al.
Pengzhen Cheng et al.
Epiphysis is an organized and dynamically evolving developmental tissue that is susceptible to physical damage. At present, significant challenges in developing complex and controllable substitutes for epiphyses persist. In this study, huma...
Self-assembly driven nano-salinomycin for high-efficiency cancer immunotherapy by reticulum stress mediated stemness suppression [0.03%]
通过内质网压力介导的干细胞性抑制实现高效癌症免疫治疗的纳米盐霉素自组装
Longqin Wang,Wenting Cheng,Siyuan Qin et al.
Longqin Wang et al.
Cancer cells with stemness characteristics effectively escape the recognition and killing of immune-active cells, such as T cells, which has been considered as the root cause of cancer recurrence and metastasis. To sensitize cancer immunoth...
Liposomal Emodin: A nanomedicine for two-photon imaging and mitochondria-targeted photodynamic therapy of psoriasis [0.03%]
脂质体大黄素：用于银屑病的双光子成像和线粒体靶向光动力疗法纳米药物
Jiachen Sun,Ao Sun,Yimeng Wang et al.
Jiachen Sun et al.
Psoriasis is a chronic, immune-mediated inflammatory skin disorder that severely affects patients' life quality due to its persistent nature, high recurrence rate, and limited treatment efficacy. In this study, we develop liposomal emodin (...
Photo-triggered engineered microbes achieving dual epigenetic immunomodulation for gastric cancer [0.03%]
用于胃癌治疗的光触发工程细菌实现双重表观遗传免疫调节
Chuyun Lou,Yitong Li,Ruonan Zhan et al.
Chuyun Lou et al.
DNA methylation serves as an essential epigenetic mechanism for the regulation of gene expression. One of the earliest and most common changes seen in cancer is abnormal DNA methylation at CpG sites, which may encourage tumor development by...
Multifunctional copper-light synergistic prodrug nanosystems for specific reprogramming of tumour immunogenic endoplasmic reticulum stress [0.03%]
用于特异性重新编程肿瘤免疫原性内质网应激的多功能铜-光协同前药纳米系统
Hongwei Lu,Weisin Chen,Chao Jia et al.
Hongwei Lu et al.
Inducing lethal endoplasmic reticulum (ER) stress is a key initiative to counteract tumour resistance and induce anti-tumour immunity. However, conventional ER stress inducers are largely limited by hypoxia and off-target effects to induce ...
An activatable polymeric nano-spy for reversing the progression of diabetic osteoporosis [0.03%]
一种可激活的聚合物纳米探测器可逆转糖尿病性骨质疏松进展
Shenhua Li,Zhibo He,Ran Zhu et al.
Shenhua Li et al.
Diabetic osteoporosis (DOP), a grievous complication of diabetes mellitus, is marked by accelerated bone loss and heightened fracture susceptibility, thereby necessitating early detection and therapeutic intervention. To address this unmet ...
Proteolysis-targeting chimera (PROTAC) nanomedicines toward cancer treatment: From synthesis to therapeutic delivery [0.03%]
用于癌症治疗的蛋白质降解嵌合体（PROTAC）纳米药物：从合成到治疗递送
Yilin Liu,Xiao Zhang,Xiaoyuan Chen et al.
Yilin Liu et al.
Proteolysis-targeting chimera (PROTAC) has emerged as a groundbreaking therapeutic strategy by hijacking the endogenous ubiquitin proteasome system (UPS) for targeted protein degradation. These heterobifunctional molecules recruit E3 ligase...
Subcellular distribution of Prussian blue nanozymes dictates enzymatic activity and macrophage polarization for effective colitis therapy [0.03%]
亚细胞定位决定普鲁士蓝纳米酶的酶活性及巨噬细胞极化用于有效的结肠炎治疗
He Ding,Mengmeng Long,Yuehuang Wu et al.
He Ding et al.
As a typical multi-enzymic nanozyme, Prussian blue nanozymes (PBNZs) mimic the catalytic functions of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD) enzymes in a pH-dependent manner. Due to their capacity to modulate react...
Directed differentiation of human mesenchymal stromal cells into functional endothelial cells having IKAROS-mediated immune tolerance properties [0.03%]
人类间充质基质细胞向具有IKAROS介导的免疫耐受功能的内皮细胞的定向分化
Jung-Kyu Han,Haena Lee,Dasom Shin et al.
Jung-Kyu Han et al.
We report an efficient method for the directed differentiation of mesenchymal stromal cells derived from embryonic stem cells (EMSCs) into functional endothelial cells (EC), addressing the challenges of direct conversion, such as cellular s...
Eliminating intratumoral bacteria with cGAS-STING-activating nanodrug-bacteria biohybrids potentiates cancer immunotherapy [0.03%]
具有激活cGAS-STING作用的纳米药物细菌生物杂化体清除瘤内菌群可增强癌症免疫疗法效果
Xiawei Zhou,Xiuhua Pan,Ziqi Shen et al.
Xiawei Zhou et al.
Breast cancer remains a leading cause of cancer-related mortality in women, with intratumoral bacteria playing a significant role in immunosuppression. However, targeted therapeutic strategies to address this microbial influence remain unde...