Regulating cell stress responses by nitric oxide to enhance calcium overload-mediated tumor therapy [0.03%]
通过调节细胞压力反应增强钙超载介导的肿瘤治疗中的硝酸氧化物作用
Xue Zhou,Chencheng Gao,Cuimei Liu et al.
Xue Zhou et al.
Amino acid (AA)-based nanoparticles (NPs) hold promise in cancer therapy due to their excellent biocompatibility and the various therapeutic functions derived from AA monomers. Here, we developed a universal one-step method to synthesize AA...
ROS-responsive resiquimod prodrug nanoparticles for macrophage reprogramming and enhanced immune checkpoint inhibitor therapy in bladder cancer [0.03%]
用于重编程巨噬细胞和增强免疫检查点抑制剂膀胱癌治疗的ROS响应型resiquimod前药纳米粒
Rui Geng,Haojie Shang,Zhiqiang Chen et al.
Rui Geng et al.
Bladder cancer remains a formidable challenge, especially for patients who fail to respond adequately to immune checkpoint inhibitors (ICIs). The suboptimal efficacy of current treatments underscores an urgent need for more effective immuno...
Glucose-responsive hydrogel with adaptive insulin release to modulate hyperglycemic microenvironment and promote wound healing [0.03%]
自适应响应血糖水平释放胰岛素的水凝胶用于调节高糖微环境及促进伤口愈合研究
Yilin Zhou,Xiaoyang Liang,Ziyi Shen et al.
Yilin Zhou et al.
The hyperglycemic microenvironment contributes to the prolonged healing of diabetic wounds by impeding angiogenesis, cell proliferation, and migration. Insulin, a prevalent blood glucose-lowering pharmaceutical agent, has demonstrated the c...
Oriented porous microtubules combined with CNTF-delivery directional guide axonal regeneration after traumatic optic neuropathy [0.03%]
导向多孔微管联合CNTF缓释支架引导视神经创伤后轴突再生修复
Xiaobin Ren,Qinying Huang,Zhenyuan Xie et al.
Xiaobin Ren et al.
Neuroinflammation microenvironment and retinal ganglion cell (RGC) apoptosis are two critical barriers to axonal regeneration following traumatic optic neuropathy (TON). To overcome these challenges, we developed an innovative dual drug del...
Tumor-activated nanocomplex reprograms cancer and macrophage metabolism in opposite directions to overcome immune suppression [0.03%]
肿瘤激活的纳米复合物可逆向重编程癌细胞和巨噬细胞代谢以克服免疫抑制
Zan Dai,Qiaoyun Wang,Ming Zhang et al.
Zan Dai et al.
Immunotherapy efficacy is hindered by the immunosuppressive metabolism of cancer cells and tumor-associated macrophages (TAMs), yet their opposite metabolic programs complicate synchronized modulation of tumor microenvironment. Here, we rep...
Porous microscaffold enables spontaneous hematopoietic cell differentiation and continuous macrophage production from hPSCs for therapy [0.03%]
多孔微支架可促进人多能干细胞分化并持续产生巨噬细胞用于治疗
Peiliang Wang,Hui Qiu,Xia Chen et al.
Peiliang Wang et al.
Macrophages play critical roles in various physiological and pathological processes, yet their scalable production for therapeutic applications remains a challenge. Here, we present a porous microscaffold (PMS) that enables robust hematopoi...
Ferrous fluoride nanoinitiators reprogram tumor stemness to empower ultrasound-augmented pyroptosis for potent catalytic immunotherapy [0.03%]
铁氟化物纳米引发剂重编程肿瘤干细胞特性以增强超声增敏的细胞焦亡用于协同催化免疫治疗
Shumin Sun,Nailin Yang,Jihu Nie et al.
Shumin Sun et al.
Pyroptosis, a pro-inflammatory programmed cell death mechanism, plays a pivotal role in immune activation. While ultrasound (US)-enhanced catalytic therapy can trigger pyroptosis through increased oxidative stress, tumor cells frequently ci...
Delivery of cytokines via encapsulated human astrocytes for neural immunomodulation [0.03%]
包裹人星形胶质细胞递送细胞因子用于神经免疫调节
Samira Aghlara-Fotovat,Maria D Montalvo-Parra,Sajedeh Nasr Esfahani et al.
Samira Aghlara-Fotovat et al.
Modulating neuroinflammation with biomaterial advancements has potential for restoring normative function in a wide variety of neuropathologic conditions. Because astrocytes dynamically react to the microenvironment and contribute to the ne...
Injectable and self-healing fucoidan hydrogel: A natural anti-inflammatory biomaterial [0.03%]
可注射和自愈的岩藻聚糖水凝胶：一种天然抗炎生物材料
Shajia Afrin,Omanin Siddiqua Prova,Asma Talib Qureshi et al.
Shajia Afrin et al.
Fucoidan, a natural sulfated polysaccharide, offers immense potential as a natural immune-modulatory bioactive polymer to develop hydrogels for tissue engineering. Yet, systematically tunable hydrogels composed primarily of fucoidan, that c...
Corrigendum to 'Reprogramming tumor microenvironment with precise photothermal therapy by calreticulin nanobody-engineered probiotics' [Biomaterials 314 (2015) 122809] [0.03%]
“利用钙网蛋白纳米抗体工程益生菌精准光热疗法重编程肿瘤微环境”一文的勘误通知
Liuhai Zheng,Huifang Wang,Xiaoru Zhong et al.
Liuhai Zheng et al.
Published Erratum
Biomaterials. 2025 Aug 26:123646. DOI:10.1016/j.biomaterials.2025.123646 2025