Photoresponsive electrospun fiber scaffold enables on-demand cytokine delivery for biomimetic endochondral bone regeneration [0.03%]
光响应静电纺纤维支架能够实现按需递送细胞因子用于仿生内ochondral骨再生
Chengao Gao,Nan Tang,Jiahao Li et al.
Chengao Gao et al.
Critical-sized bone defect repair remains a formidable challenge because conventional approaches cannot recapitulate the temporally coordinated cascade of endochondral ossification. Here, we report a biomimetic, temporally programmed cytoki...
Biomimetic aligned scale-like nanotopographic scaffold reprograms resorption-dominant remodeling in diabetic sockets to enhance alveolar ridge preservation [0.03%]
类骨质鳞片状纳米拓扑支架可重塑糖尿病窝裂吸收主导的重塑模式以增强牙槽ridge保存能力
Jiawei Xing,Jiacheng Lv,Ze He et al.
Jiawei Xing et al.
Spatiotemporally patterned alveolar ridge resorption after tooth extraction compromises subsequent implant placement and esthetic rehabilitation. This challenge is aggravated in diabetes, where chronic inflammation and excessive osteoclast ...
Macrophage polarization-inducible cholesterol lipid-assisted nanoparticles prime systemic antitumor immunity [0.03%]
巨噬细胞极化诱导胆固醇脂质纳米颗粒辅助调节全身抗肿瘤免疫反应
Bofu Ma,Miao Su,Boya Yu et al.
Bofu Ma et al.
Nanomaterials with intrinsic biological activity can directly participate in disease treatment, emerging as a pivotal focus in the development of next-generation therapeutics. In this study, we synthesized a library of cholesterol lipids be...
Bioprinted cell-instructive lung-dECM constructs for reconstructing an immuno-regenerative pulmonary microenvironment [0.03%]
用于重建免疫再生性肺微环境的生物打印细胞指令性肺脱细胞基质构建体
Soham Ghosh,Falguni Pati
Soham Ghosh
Pulmonary tissue engineering requires scaffolds that combine parenchymal mechanical compliance with extracellular matrix-bound instructive cues, yet soft materials often lack print fidelity. Here, we developed decellularized lung matrix (dL...
A boronate-phenolic network nanoplatform carrying dimethyl itaconate for ameliorating neovascular age-related macular degeneration [0.03%]
负载双甲基衣康酸的硼酸-酚类网络纳米平台用于改善新生血管年龄相关性黄斑变化
Yufeng Xu,Mingyu Xu,Jiqiao Qie et al.
Yufeng Xu et al.
Age-related macular degeneration (AMD), particularly its neovascular form driven by choroidal neovascularization (CNV), remains leading cause of irreversible blindness worldwide. Current anti-vascular endothelial growth factor (VEGF) therap...
Self-powered electro-activated MgxFe1-xS2 scaffold for gas-ion therapy in osteosarcoma suppression and bone regeneration [0.03%]
自驱动电活化MgxFe1-xS2支架用于气离子治疗以抑制骨肉瘤和促进骨再生
Botao Lu,Zeyu Chen,Shichao Yan et al.
Botao Lu et al.
Postoperative treatment of osteosarcoma faces the dual challenges of tumor recurrence and extensive bone defect repair, necessitating the development of a synergistic strategy capable of simultaneously eliminating residual tumor cells and p...
A carrier-within-a-carrier system with calcium nanoparticles encapsulated in β-cyclodextrin-polysaccharide hydrogel for verteporfin delivery and radiosensitization in orthotopic osteosarcoma [0.03%]
一种递送载体：将β-环糊精多糖水凝胶包封的钙纳米颗粒用于正交位肿瘤模型中verteporfin的传递和放射增敏研究
Jiayi Liu,Xuehao Tian,Alifujiang Hairulajiang et al.
Jiayi Liu et al.
Osteosarcoma remains a clinical challenge due to its high invasiveness, early metastasis, and intrinsic radioresistance, which collectively limit the efficacy of conventional treatments and immunotherapy. Here, we developed a pH-responsive ...
Transient culture of adult human hepatocytes as organoids improves engineered liver engraftment [0.03%]
类器官化的成人肝脏上皮细胞系具有更好的移植治疗潜力
Sarah H Saxton,Inkyung Kang,Shannon Mitchell et al.
Sarah H Saxton et al.
Bioengineered livers could serve as a bridge or alternative to whole organ transplantation for patients suffering from liver disease. However, identifying cellular configurations that promote adult human hepatocyte survival after tissue tra...
Triple-modal PPy/ZIF-8 nanoparticles amplify autophagy and block autophagic flux via photothermal-ROS-zinc ion synergy for cancer therapy [0.03%]
三模态PPy / ZIF-8纳米粒子通过光热- ROS-锌离子协同作用放大自噬并阻断自噬流量用于癌症治疗
Canyi Chen,Qinqing Tang,Qinyao Xu et al.
Canyi Chen et al.
Targeted autophagy regulation holds great promise for antitumor therapy, whereas conventional single-modal autophagy interventions easily induce compensatory escape of tumor cells and fail to transform protective autophagy into a lethal phe...
A new biomaterial and molecular imaging platform: Click-coupled dual-responsive fluorescent signaling for deciphering the ROS-RSS imbalance in kidney injury [0.03%]
一种新的生物材料和分子影像平台：适用于肾脏损伤中ROS-RSS失衡解析的“点击化学”双刺激响应型荧光信号报告体系研究
Yongchuang Li,Haiyue Liu,Songhan Liu et al.
Yongchuang Li et al.
As the sophisticated "purification factory", kidney performs pivotal functions from blood filtration to endocrine regulation. Consequently, renal injury will trigger "domino effect" culminating in multiple organ failure, posing unavoidable ...