PD-L1 intracellular domain-mimicked poly-metformin synergistically enhances macrophage antigen presentation for colorectal cancer oral immunotherapy [0.03%]
基于PD-L1胞内结构域的多甲福明共聚物协同增强巨噬细胞抗原呈递用于结直肠癌口服免疫治疗
Shengjie Sun,Yixuan Fang,Huisong Hao et al.
Shengjie Sun et al.
As the most prevalent subtype of colorectal cancer, microsatellite-stable colorectal cancer (MSS CRC) is resistant to T cell-focused immune checkpoint blockade due to its low mutational burden and immunosuppressive tumor microenvironment. D...
Enhancing neural communication via activating calcium-dependent signals toward spinal cord injury repair [0.03%]
通过激活钙离子依赖性信号增强神经通讯以修复脊髓损伤
Jiashang Liu,Chunjun Zhao,Changsheng Liu et al.
Jiashang Liu et al.
Spinal cord injury (SCI) is a severe neurological disease resulting in the formation of a harsh microenvironment that hinders neural regeneration. By preserving the components and structure of natural tissues, the decellularized extracellul...
An immune-adaptive 3D-printed scaffold promotes endogenous osteogenesis by engineered macrophage capture traps [0.03%]
一种免疫自适应的3D打印支架通过工程化巨噬细胞捕获陷阱促进内源性成骨作用
Zhenrong Zhu,Peiyang Gu,Xing Li et al.
Zhenrong Zhu et al.
Macrophages serve as central units in immune regulation, with their polarization influencing distinct stages of the bone healing process. Here, we report an immune-adaptive 3D-printed scaffold that integrates engineered macrophage capture t...
Magnetic hydrogel encapsulation combined with on-chip processing enhances straw vitrification of mouse oocytes [0.03%]
磁性水凝胶包埋结合芯片处理技术增强小鼠卵母细胞吸管玻璃化的研究
Yu Lei,Zhixiang Fang,Mulin Wei et al.
Yu Lei et al.
Oocyte cryopreservation represents a cornerstone technology in assisted reproductive medicine and biodiversity conservation. In this field, microfluidic chips have emerged as promising tools for minimizing osmotic shock and other damage thr...
Glucose/ROS-dual-responsive injectable hydrogel ameliorates myocardial infarction by restoring metabolic homeostasis in diabetic rats [0.03%]
葡萄糖/ROS双响应性可注射水凝胶通过恢复糖尿病大鼠的心肌代谢平衡来改善心肌梗死状况
Guangbing Luo,Xin Zhang,Yintong He et al.
Guangbing Luo et al.
Injectable hydrogels capable of responding to pathological microenvironmental cues represent a promising therapeutic strategy for myocardial infarction (MI). However, existing systems that can simultaneously regulate metabolic abnormalities...
A unified magnetic nanoprobe enables multi-sequence MRI mapping of post-stroke cerebrovascular and glymphatic injuries [0.03%]
一种统一的磁性纳米探测器可使中风后的脑血管和淋巴管损伤多序列磁共振成像映射
Xunxiao Zhao,Xue Li,Yan Gong et al.
Xunxiao Zhao et al.
The coupled impairment of the cerebrovascular network and the glymphatic system is a critical pathological feature of stroke. However, comprehensively assessing this dual-pathway damage remains a significant clinical challenge. Current clin...
A proton-gated gold nanocluster platform for disrupting biofilm bioenergetics and suppressing virulence in bacterial infections [0.03%]
一种用于破坏生物膜生物能量和抑制细菌感染中毒力的质子门控金纳米团簇平台
Jia Liu,Xiaolin Sun,Jing Zhou et al.
Jia Liu et al.
Current clinical management of periodontitis, a chronic inflammatory disease driven by dysbiotic biofilms, faces a persistent challenge: biofilm-associated infections remain difficult to eradicate owing to the resilient energy metabolism an...
ROS-responsive hydrogel nanoarmor enables stepwise photodynamic viral inactivation and sustained anti-inflammation for monkeypox therapy [0.03%]
ROS响应性水凝胶纳米护甲可用于灵猴痘病毒的逐步光动力灭活及长效抗炎治疗
Ning Shi,Xinyu Cao,Xiaolong Zhu et al.
Ning Shi et al.
Currently, monkeypox virus (MPXV) treatment methods face a dilemma of potential drug resistance. They cannot simultaneously address two core pathological mechanisms driving infection: continuous viral replication and uncontrolled inflammato...
Shuyi Cao,Xuejiao Wang,Xiaole Bai et al.
Shuyi Cao et al.
Radiation-induced heart disease (RIHD) is a significant late complication of radiotherapy for thoracic malignancies, limiting cancer control and patient well-being. Although RIHD has been extensively studied, its precise molecular mechanism...
Coassembled peptide nanoparticles enable stage-specific diagnosis and targeted therapy of hepatic fibrosis by inhibiting macrophage-driven inflammation [0.03%]
肽类共组装纳米粒子通过抑制巨噬细胞驱动的炎症实现肝纤维化分期特异性诊断和靶向治疗
Bowen Li,Chenchen Pan,Yuerong Ma et al.
Bowen Li et al.
Hepatic fibrosis represents a major unmet clinical challenge, given its insidious progression and the lack of effective diagnostic and therapeutic strategies. To address this gap, we constructed supramolecular assemblies integrating an anti...