Blockade of metastasis by targeting circulating tumor cells with platelet encapsuled oncolytic adenovirus [0.03%]
携带溶瘤腺病毒的血小板封包体阻断循环肿瘤细胞介导的转移
Chao Su,Linlin Song,Xin Wang et al.
Chao Su et al.
Host immune elimination largely limits the application of oncolytic viruses in clinics. Here, we rationally design a bioactive platelet-based oncolytic adenovirus delivery system. Upon loading adenoviruses, platelets are transformed to a pr...
Polymer-based gene-drug co-delivery system effectively inhibits pathologic retinal neovascularization through dual anti-inflammatory and anti-neovascular actions [0.03%]
基于聚合物的基因药物共递送系统通过双重抗炎和抗血管生成作用有效抑制病理性视网膜新生血管形成
Mengtian He,Dayang Xie,Qiannan Cao et al.
Mengtian He et al.
Retinal neovascularization is one of the most prevalent fundus neovascular diseases, affecting vision and potentially leading to severe complications, such as retinal detachment or irreversible blindness. Current treatments primarily involv...
Sustained release of dual p38 inhibitors via supramolecular hydrogels to enhance cardiac repair after MI/R injury [0.03%]
通过超分子水凝胶持续释放双重p38抑制剂以增强MI/R损伤后的心脏修复作用
Di Wang,Aoxue Xu,Haitao Su et al.
Di Wang et al.
Activation of p38 mitogen-activated protein kinase plays an important role in the progression of ventricular muscle inflammation after myocardial ischemia-reperfusion (MI/R). The inhibition of p38 activation in ischemic myocardium can reduc...
Engineering ferroptosis radiosensitizer for SPARC-targeted degradation: A strategy to reverse radioresistant non-small cell lung cancer [0.03%]
工程化铁死亡放疗增敏剂以降解SPARC：逆转非小细胞肺癌放射耐药性的策略
Reyida Aishajiang,Yuan Liang,Pengye Du et al.
Reyida Aishajiang et al.
Radioresistance poses a significant obstacle in the management of Non-Small Cell Lung Cancer (NSCLC), often diminishing the effectiveness of radiotherapy and leading to treatment failures and adverse clinical outcomes. This study develops r...
Targeted degradation of hexokinase 2 by a novel engineered bispecific chimeric liposome-based Nano-PROTACs for enhancing tumor chemotherapy [0.03%]
一种新型工程化双特异嵌合脂质体基纳米 PROTAC 降解己糖激酶 2 增强肿瘤化疗
Linlin Gong,Shasha Li,Jiahui Sun et al.
Linlin Gong et al.
Aerobic glycolysis is critical for tumor development and metastasis. Regulating the activity of vital metabolic enzymes in the tumor glycolysis process, such as hexokinase 2 (HK-2), is expected for tumor treatment. However, conventional sma...
Ligand-metal charge transfer-enabled copper-gallate nanozyme rescue oxidative stressed reparative cells for inflammatory dental tissue regeneration [0.03%]
用于发炎牙组织再生的配体金属电荷转移铜-氧化镓纳米酶解救修复细胞内的氧化应激损伤
Xueye Liu,Haoyang Tian,Danyang Wang et al.
Xueye Liu et al.
Dental tissue regeneration is often challenged by the hostile inflammatory microenvironment and the dysfunction of reparative cells due to oxidative stress. This study presents a reactive oxygen species (ROS)-scavenging nanozyme induced by ...
The FN1-targeted delivery of low-molecular-weight heparin to venous clots revolutionizes thrombosis treatment in CVT [0.03%]
针对静脉血栓的FN1靶向低分子肝素递送技术革新了CVT的治疗方案
Huimin Jiang,Jian Chen,Yifan Zhou et al.
Huimin Jiang et al.
The systemic administration of low-molecular-weight heparin (LMWH) as the standard initial treatment for venous thromboembolism is intended to prevent thrombus growth during the acute phase and prevent thrombus recurrence during the chronic...
Smart microenvironment-activatable silybin nano-prodrug for precise NIR-II fluorescence monitoring and on-demand therapy of acute liver injury [0.03%]
一种智能微环境激活silybin纳米前药，用于急性肝损伤的精确NIR-II荧光监测和按需治疗
Jie Dong,Yahong Han,Ru Feng et al.
Jie Dong et al.
Acute liver injury (ALI) is a serious disease characterized by liver function impairment caused by multiple causes in a short period of time. Due to lack of precise diagnosis and timely intervention, many patients with ALI rapidly progress ...
Nanoparticles reveal permanent and reversible changes to lymph node biomechanics during inflammatory response [0.03%]
纳米颗粒揭示了淋巴结在炎症反应过程中的永久性和可逆性生物力学变化
Ann Ramirez,Vedanth Sriram,Yassmin Abbouchi et al.
Ann Ramirez et al.
Lymph nodes are highly specialized immune organs that orchestrate the adaptive immune response. In the lymph nodes, naïve B and T lymphocytes encounter cognate antigens, sparking their activation and response to foreign substances. Lymph n...
Scar-reducing ionically conductive chitosan bandage: Combining ionic and electrical stimulation for optimal wound healing [0.03%]
一种减少疤痕的离子导电壳聚糖绷带：结合离子和电刺激实现最佳伤口愈合效果
Sama Abdulmalik,Sangamesh G Kumbar
Sama Abdulmalik
Large, complex wounds frequently exhibit suboptimal healing, leading to scarring and functional impairment. While bioactive materials and electrical stimulation (ES) show promise, their individual limitations call for novel approaches. This...