Coupling intraoperative bioprinting and surgical micropuncture for synergistic scaffold vascularization [0.03%]
结合术中生物打印和手术微穿刺实现协同支架血管化
Miji Yeo,Jessica C El-Mallah,Summer N Horchler et al.
Miji Yeo et al.
Intraoperative bioprinting (IOB) is an advanced approach enabling the reconstruction of tissue defects by precisely bioprinting biologics under surgical settings. However, IOB has limited translational potential in its current form secondar...
Biomimetic mineralized xenogenic acellular cartilage matrix promotes the repair of osteochondral defects and the recovery of motor function [0.03%]
仿生矿化异源去细胞软骨基质促进软骨缺损修复及运动功能恢复
Yuxuan Wei,Hanbin Liao,Hao Guo et al.
Yuxuan Wei et al.
Osteochondral lesion with subchondral bone cyst formation is clinically challenging. As the gold standard, autologous osteochondral transplantation has some problems such as limited source, donor-site complications and delayed subchondral b...
Microfluidic fabricated cell-laden microgels aggregated into artificial liver microtissue to ameliorate drug-induced liver injury [0.03%]
微流控技术制备的含细胞微凝胶聚合成人工肝组织以改善药物性肝损伤
Fenfang Li,Tiantian Xue,Yanteng Xu et al.
Fenfang Li et al.
Acute liver failure (ALF) is a life-threatening disease for which orthotopic liver transplantation remains one of the most effective treatments. Cell therapy, particularly through the transplantation of artificial bioengineered liver grafts...
Transcriptomic analysis of the physiological responses to injuries induced accompanying intracortical microelectrode implantation [0.03%]
颅内微电极植入损伤诱导的生理响应转录组分析
Johnathan R T Huff,Jaime Wang,Yue Gao et al.
Johnathan R T Huff et al.
The neuroinflammatory response to intracortical microelectrodes (IMEs) is regarded as a major contributor to device performance degradation and failure. Iatrogenic injuries from the craniotomy, IME insertion, and the continued presence of t...
Multifunctional bilayer scaffold for dental pulp protection and sustained calcium hydroxide release for mineralized tissue regeneration [0.03%]
用于牙髓保护和钙氢氧化物缓释的多功能双层支架促进矿化组织再生
Caroline Anselmi,Igor P Mendes Soares,Renan Dal-Fabbro et al.
Caroline Anselmi et al.
Injury to the mineralized tissues that protect the dental pulp can lead to pulp exposure and inflammation, necessitating the use of biologically active materials capable of preserving pulp vitality. While current biomaterials such as minera...
Reprogramming the glycocalyx: Advances in glycoengineering for immunomodulation and regenerative medicine [0.03%]
糖工程重编糖萼蛋白：免疫调节和再生医学领域糖工程学的最新进展
Md Mohosin Rana,Peyman Malek Mohammadi Nouri,Seyed Hassan Hosseini et al.
Md Mohosin Rana et al.
This review explores the evolving landscape of glycoengineering on the cell surface, a pivotal field in translational medicine with profound implications for immunomodulation and regenerative therapies. The cell membrane and glycocalyx, com...
Yutao Ma,Chuxiao Xiong,Feng Guo et al.
Yutao Ma et al.
The integration of electronics with bioactive materials derived from living organisms offers a new paradigm to enable bidirectional modulation of human physiology by wearable therapeutic systems. Here, decellularized skin is integrated with...
Mengru Zhu,Zhehao Fan,Mengshuo Chen et al.
Mengru Zhu et al.
Bone organoids (BOs) are self-organizing, three-dimensional (3D) in vitro models that offer a promising platform for recapitulating the intricate components, architecture and functionality of native bone. However, accurately mimicking the h...
The "barrier-erecting" of titanium dental implant: Surface modification strategies for enhancing soft tissue integration [0.03%]
钛种植体界面屏障的构建策略：改善软组织结合的表面修饰方法研究进展
Yue Yuan,Minghao Zhou,Jingwei Yu et al.
Yue Yuan et al.
Due to the persistently high prevalence of tooth loss, the demand for dental titanium implants is steadily increasing. Soft tissue integration around the implant serves as a critical biological barrier against external factors, which is ess...
Nanotherapeutics for microenvironment modulation and immune homeostasis in periodontitis treatment [0.03%]
纳米药物在牙周病治疗中用于微环境调节和免疫平衡保持
Tao Zhou,Yaxin Xie,Ao Cheng et al.
Tao Zhou et al.
Periodontitis is a prevalent chronic inflammatory disease characterized by progressive destruction of tooth-supporting tissues, which may cause tooth loss and is closely linked to various systemic diseases. Recent insights into the immunopa...