Fe/Zn composite with high strength-ductility, large-area galvanic corrosion, antibacterial, angiogenic, and osteointegrative capabilities for biodegradable bone-fixation applications [0.03%]
一种用于可降解骨固定应用的高强度高延展性、大面积微电池腐蚀、抗菌、促血管生成和促成骨整合能力的铁/锌复合材料
Xian Tong,Yue Han,Lanxin Gu et al.
Xian Tong et al.
Iron/zinc (Fe/Zn) composite may offer an accelerated degradation rate for bone-implant applications due to the large interfaces between its different constituents. Nevertheless, it is challenging to fabricate a biodegradable composite that ...
Micro/nanomotors for biofilm remediation: Nanoarchitectonic breakthroughs with a focus on regulatory and clinical translation challenges [0.03%]
微纳米马达在生物膜修复中的应用：以监管和临床转化为重点的纳米架构突破
Tijana Maric,Yuya Tanaka,Ziqiao Li et al.
Tijana Maric et al.
Biofilm-associated bacterial infections, notorious for their resistance to standard therapies, pose a critical challenge in clinical practice. Micro and nanomotors (MNMs) have emerged as dynamic tools capable of penetrating biofilm matrices...
Thrombin-regulated multi-functional hydrogel coating for decellularized extracellular matrix materials to enhance the anticoagulant and endothelialization properties [0.03%]
一种新型凝血酶响应的多功能水凝胶涂层改善脱细胞基质材料的抗凝和内皮化性能
Hongxia Pu,Tao Yu,Yao Xiong et al.
Hongxia Pu et al.
Valvular heart disease (VHD) is a leading global health concern, contributing to significant mortality rates and imposing substantial economic burdens annually. To date, numerous bioprosthetic heart valves (BHVs) based on decellularized ext...
Unconventional bioprinting modalities for advanced tissue biofabrication [0.03%]
用于高级组织生物制造的非常规生物打印模式
I Deniz Derman,Myoung Hwan Kim,Medine Dogan Sarikaya et al.
I Deniz Derman et al.
Bioprinting has been widely used to fabricate three-dimensional constructs for various applications. However, conventional bioprinting modalities face challenges such as low resolution, poor repeatability, limited speed, and scalability con...
Fully synthetic nanofibrillar hydrogel for the growth and enzyme-free release of patient-derived ovarian tumor organoids [0.03%]
用于患者衍生的卵巢肿瘤类器官生长和无酶释放的全合成纳米原纤维水凝胶
Yixiong Duan,Yuchuan Jin,Yiyang Jia et al.
Yixiong Duan et al.
Patient-derived tumor organoids (PTOs) closely recapitulate the histopathology, gene expression, and drug response of patient tumor tissues, thereby making them highly reliable in vitro models in preclinical cancer research. Currently, base...
Multimodal induction of stem cells synergistically mediates enhanced cartilage-bone cross-talk in a 3D bioprinted human osteochondral microphysiological system [0.03%]
多模式诱导干细胞协同调节3D生物打印人骨软骨微生理系统中的软骨-骨交互作用
Souradeep Dey,Pragya Mehra,Chitra Jaiswal et al.
Souradeep Dey et al.
A humanized microphysiological system (MPS) emulating the morphophysiology of the osteochondral complex can revolutionize research and drug development for joint diseases. Despite significant efforts, in vitro osteochondral models fail to r...
Emerging frontiers in microRNA technology: Innovations driving precision medicine [0.03%]
微小核糖核酸技术新兴前沿：精准医学的创新引擎
Shanshan Guo,Yiming Wang,Hongxin Zhao et al.
Shanshan Guo et al.
MicroRNAs (miRNAs) play a central role in gene regulation and have emerged as critical tools in disease diagnosis, therapy, and precision medicine. However, the field faces major challenges, including insufficient sensitivity and specificit...
Daksh Mehta,Eileen Gentleman
Daksh Mehta
Strontium-containing biomaterials offer promising avenues for enhancing bone repair by leveraging the ion's reported dual anabolic and anti-catabolic effects on bone cells. These biomaterials aim to encourage site-specific bone growth, heal...
A nerve conduit optimizing the microenvironment for neurorepair in long-segment nerve injury using silk fibroin-MXene conductive nerve guide and IGF-1/GelMA hydrogel [0.03%]
基于 silk fibroin-MXene 导电神经导管和IGF-1/GelMA水凝胶构建优化微环境的长节段神经损伤修复桥接支架
Lan Zeng,Kang Ma,Ying Huang et al.
Lan Zeng et al.
Long-segment peripheral nerve injury (PNI) represents a significant global health challenge, often leading to sensory and motor deficits, neuropathic pain, and secondary complications. Early reconnection of injured nerves is essential for p...
Biomaterials-based strategy for dental-oral tissue regeneration: current clinical application, laboratory development, and future direction [0.03%]
基于生物材料的牙科口腔组织再生策略：当前临床应用、实验室开发和未来方向
Lili Li,Jieyun Xu,Chen Ye et al.
Lili Li et al.
The oral cavity presents unique regenerative challenges due to its complex developmental origins, intricate interfaces between hard and soft tissues, and constant exposure to mechanical forces, saliva, and a diverse microbiota. Along with m...