Tumor microenvironment-responsive NanoShield for precision photodynamic and photothermal synergistic cancer therapy with mitigated skin phototoxicity [0.03%]
一种用于精准光动力和光热协同癌症治疗且减轻皮肤光毒性的肿瘤微环境响应型NanoShield
Liping Zhang,Yilin Zhu,Rongyuan Zhang et al.
Liping Zhang et al.
Photodynamic therapy (PDT) is a highly promising non-invasive cancer treatment but is often hampered by severe skin phototoxicity arising from the nonspecific distribution of photosensitizers (PSs). Stimuli-responsive aggregation-induced em...
Multifunctional exosome-driven tumor immunotherapy sensitization: converting intratumoral bacteria into antitumor fighters [0.03%]
多功能的外泌体驱动肿瘤免疫治疗增敏：将瘤内细菌转化为抗肿瘤战士
Xiaoqing Wei,Yongxin Zhang,Yuxin Chen et al.
Xiaoqing Wei et al.
Utilizing intratumoral bacteria to reprogram tumor-associated macrophages (TAMs) into a tumoricidal M1 phenotype holds great potential in cancer immunotherapy. However, intratumoral bacteria cunningly hide inside tumor cells to evade the su...
Development of a biodegradable smooth-surface microcarrier for retinal pigment epithelial cell expansion and maturation [0.03%]
一种可降解的平滑微载体的开发，用于视网膜色素上皮细胞的扩增和成熟
Zengping Liu,Daniel Soo Lin Wong,Bhav Harshad Parikh et al.
Zengping Liu et al.
The retinal pigment epithelium (RPE) is essential for the health and function of the retina and, more specifically, the photoreceptors. Hence, the dysfunction of RPE leads to various retinal degeneration diseases. The rising prevalence of t...
Intracortical microstimulation induces rapid microglia process convergence [0.03%]
皮质内微刺激诱发小胶质细胞突起汇聚反应
Nathaniel P Williams,Anna M Kelly,X Sally Zheng et al.
Nathaniel P Williams et al.
Intracortical microstimulation (ICMS) has the potential to restore vision and hearing by stimulating relevant cortical regions in both animals and humans, offering significant clinical promise for sensory restoration. While the neuronal res...
Inflammation-targeted nanoplatform: NIR-II imaging-guided encephalitis suppressing by dual antioxidant-ferroptosis action [0.03%]
炎症靶向纳米平台：近红外二区成像引导的双抗氧化-铁死亡作用抑制脑炎
Qianruo Wang,Di Wang,Penghui Liu et al.
Qianruo Wang et al.
Encephalitis, a life-threatening neurological disorder with high mortality and debilitating long-term sequelae, remains a formidable clinical challenge due to limited therapeutic strategies targeting its underlying pathological mechanisms. ...
A coordinated biomaterial strategy for post-infarction cardiac repair: integrating tailored mechanical reinforcement with hiPSC-derived cardiomyocytes in composite engineered human myocardium for remuscularization [0.03%]
一种协调的生物材料策略用于心梗后心脏修复：将定制机械增强与hiPSC来源的心肌细胞结合在复合工程人心肌中，以实现重塑肌肉
Kiera D Dwyer,Arvin H Soepriatna,Caroline A Snyder et al.
Kiera D Dwyer et al.
Up to 1 billion cardiomyocytes (CMs) die during myocardial infarction (MI), leading to permanent muscle loss and devasting functional impacts. Biomaterial therapies have aimed to passively reinforce the infarcted left ventricle (LV), but th...
Dual-responsive nanoparticle system for enhanced blood-brain barrier crossing and glioblastoma penetration [0.03%]
用于增强血脑屏障穿越和胶质母细胞渗透的双响应纳米粒子系统
Ziyan Zheng,Jiawei Chen,Yan Kang et al.
Ziyan Zheng et al.
Glioblastoma (GBM) is recognized as one of the most aggressive and devastating primary brain cancers, posing a significant clinical challenge. The blood-brain barrier (BBB) significantly impedes therapeutic drug delivery, contributing to tr...
Metal-polyphenol network-engineered mesenchymal stem cell-derived exosome mimetics mediate inflammatory/immune regulation for enhanced periodontal tissue regeneration [0.03%]
金属-多酚网络工程化间充质干细胞来源外泌体模拟物介导炎性/免疫调节促进牙周组织再生
Zhi-Yan Zhou,Zhi-Bang Li,Ni-Shan Shi et al.
Zhi-Yan Zhou et al.
Exosomes represent a promising therapeutic strategy in regenerative medicine; however, challenges such as unscalable production and poor tolerance to pathological host microenvironments impede their clinical translation. To address these li...
Xiaotong Li,Ruiyin Cheng,Deng Junyi et al.
Xiaotong Li et al.
Lymph nodes (LNs) are central hubs of adaptive immunity, orchestrating T cell activation and long-term immune surveillance, making them prime targets for cancer immunotherapy. However, their inherent immunosuppressive microenvironment and t...
Biocatalytic hydrogen-bonded organic frameworks: Design and biomedical applications [0.03%]
用于设计与生物医学应用的生化氢键有机框架
Dongqin Yu,Ke Zhang,Chao Qi et al.
Dongqin Yu et al.
Hydrogen-bonded organic frameworks (HOFs), characterized by precisely engineered long-range ordered structures and tunable hydrogen-bonding networks, have emerged as a promising novel class of porous crystalline materials, particularly for ...