Advanced biomechanics and stability of the resin-dentin complex via modular A- and B-type proanthocyanidins [0.03%]
棓儿酸树脂与牙本质结合的高级生物力学及稳定性研究-A型和B型原花青素模块的作用
Mariana Reis-Havlat,Yvette Alania,Shu-Xi Jing et al.
Mariana Reis-Havlat et al.
This study explored the formation and sustainability of the resin-dentin complex optimized by four proanthocyanidins (PACs), modularly defined catechin oligomers with distinct single (B-type) or double (A-type) interflavanyl linkages (IFLs;...
A multifunctional manganese-based nanozyme platform for synergistic hypoxia alleviation and cholesterol depletion to potentiate STING-mediated cancer immunotherapy [0.03%]
一种多功能锰基纳米酶平台协同缓解缺氧和胆固醇耗竭以增强STING介导的癌症免疫治疗
Shijian Liu,Sijie Shao,Zhe Huang et al.
Shijian Liu et al.
Aberrant cholesterol accumulation and hypoxia contribute to cancer malignancy by promoting cell survival, enhancing DNA repair pathways, reducing the efficacy of the stimulator of the interferon gene (STING) activation, and creating an immu...
Efficient copper ion transport triggers in situ photothermia and cuproptosis for boosting colon cancer immunotherapy [0.03%]
高效的铜离子运输触发原位光热疗和铜依赖性细胞死亡以增强免疫疗法治疗结肠癌的效果
Yan Zhang,Weiting Sun,Xin Meng et al.
Yan Zhang et al.
Photothermal therapy (PTT) or cuproptosis based on copper ions is a crucial strategy for precise colon cancer treatment. The excessive demand for tumoral accumulation of copper ions is essential to realize cuproptosis and in situ PTT simult...
Unlocking the therapeutic potential of tumor-derived small extracellular vesicles in cancer immunotherapy: A multifaceted approach [0.03%]
解锁肿瘤来源的小细胞外囊泡在癌症免疫治疗中的治疗潜力：多管齐下的方法
Hyewon Ko,Chan Ho Kim,Soyoung Son et al.
Hyewon Ko et al.
Cancer immunotherapy represents a remarkable breakthrough in oncology. However, the efficacy of existing therapeutic modalities is observed in only a subset of patients, highlighting the need for further advancements. Tumor-derived small ex...
Piezoelectric catalytic activation of cGAS-STING pathway by Ga-based liquid metal nanoparticles for enhanced antitumor immunotherapy [0.03%]
镓基液态金属纳米颗粒介导的压电催化激活cGAS-STING通路增强抗肿瘤免疫治疗
Zining Hao,Yuchu He,Chang Liu et al.
Zining Hao et al.
The abnormal vascular structure and impaired lymphatic drainage in tumor tissue lead to interstitial fluid accumulation, resulting in elevated interstitial fluid pressure, which severely hinders the intratumoral penetration of therapeutic d...
Jiahui Du,Yilei Huang,Yulan Liu et al.
Jiahui Du et al.
Craniofacial bone reconstruction presents unique anatomical and functional challenges that differ from those associated with systemic skeletal repair, necessitating specialized regenerative strategies. Despite considerable advancements in b...
Breaking the fibrotic code: Nanotechnology-driven advances in renal fibrosis therapy [0.03%]
破解纤维化代码：肾纤维化治疗中的纳米技术驱动型进展
Minna Liu,Xiaolin Li,Yuhai Gao et al.
Minna Liu et al.
Renal fibrosis, a hallmark of chronic kidney disease progression, arises from complex pathogenic mechanisms involving inflammatory activation, myofibroblast proliferation, and excessive extracellular matrix deposition. Current treatment is ...
S100A11/ANXA2 axis mediates electrotransduction to promote electrically-induced contraction in engineered myocardial tissues [0.03%]
S100A11/ANXA2轴介导电转导以促进工程心肌组织中的电诱导收缩作用
Li Xue,Qi Zhang,Yijing Wang et al.
Li Xue et al.
Ischemic heart disease (IHD) manifests impaired myocardial systolic/diastolic and electrophysiological functions due to disrupted electrical integrity. Engineering functional myocardial tissues by modulating extracellular electrical microen...
Hongjian Zhang,Jiang Chang,Chengtie Wu
Hongjian Zhang
Oral diseases are one of global health problem with the prevalence of more than 3 billion people worldwide, which represents heavy medical burden and severely affect life quality of patients. Currently, clinical therapeutic approaches mainl...
A triple-responsive nanozyme platform of AgAu-CeO2 heterojunction integrated with probiotics for precision antibacterial therapy in periodontitis [0.03%]
一种三重响应性纳米酶平台AgAu-CeO2异质结与益生菌相结合用于牙周炎的精准抗菌治疗
Meiqi Li,Qihang Ding,Songtao Hu et al.
Meiqi Li et al.
Nanozymes hold significant promise for biomedical applications; however, their clinical translation is hindered by the mismatch between physiological conditions and their optimal catalytic environments, particularly with respect to temperat...