Advances in tissue engineering strategies for periodontal and endodontic regeneration: Current therapies and future trends for disease treatment and tissue repair in the oral cavity [0.03%]
牙周和根尖再生的组织工程技术最新进展：口腔疾病治疗和组织修复的当前疗法及未来趋势
Eamon J Sheehy,Niamh Coffey,Ross M Quigley et al.
Eamon J Sheehy et al.
Tissue damage within the oral cavity caused by periodontal and endodontic diseases impart significant socioeconomic and healthcare impacts on the global population. In addition to the negative aesthetic effects, such oral diseases cause inc...
Dual-release 3D-printed porous Ti-6Al-4V implant with drug-eluting photothermal micro-nanotopographies: combating osteosarcoma recurrence, infections, and enhancing osteogenesis [0.03%]
具有药物洗脱光热微纳拓扑结构的双释放3D打印多孔Ti-6Al-4V植入物：防治骨肉瘤复发、感染及促进成骨作用
Zhenbing Ji,Yi Wan,Yujin Zou et al.
Zhenbing Ji et al.
3D-printed porous Ti-6Al-4V implants are widely used in bone defect repair following osteosarcoma resection due to their favorable mechanical properties and biocompatibility. However, eliminating residual tumor cells, preventing bacterial i...
A novel nano-biocomposite synergistically activates PANoptosis and cGAS-STING for precise cancer immunotherapy [0.03%]
一种新型纳米生物复合材料可协同激活PANoptosis和cGAS-STING用于精准癌症免疫治疗
Guoqing Zhu,Yanrong Qian,Minghong Gao et al.
Guoqing Zhu et al.
Although cancer immunotherapy has achieved significant progress in clinical practice, the uneven distribution of nanomaterials across the body, as well as the insufficient precision of current immunotherapy remain critical challenges. In th...
Ultrasound-activated piezoelectric nano-armor for in-situ vascular repair on vascular implants [0.03%]
血管植入物原位血管修复的超声激活压电纳米护甲
Tiantian Zheng,Yuan Feng,Haoshuang Wu et al.
Tiantian Zheng et al.
Achieving rapid and healthy endothelialization while suppressing pathological responses remains a critical challenge in cardiovascular implant therapy. However, replicating this process within the intricate milieu of the vasculature present...
Generation of engineered human spinal cord organoid in channel-patterned collagen and transplantation for spinal cord regeneration [0.03%]
基于通道培养胶原生成脊髓类器官及其移植促进脊髓损伤修复
Liang Ma,Zhen Zhang,Yulei Mu et al.
Liang Ma et al.
The construction of artificially manipulable tissue-engineered human spinal cord organoids (HSCO) in vitro is crucial for recapitulating spinal cord development and facilitating the transplantation repair of complete spinal cord injury (SCI...
Juncen Zhou,Yingchao Su,Hanbo Wang et al.
Juncen Zhou et al.
Conventional temporary epicardial pacing wires (TPWs) are widely used for postoperative pacing support but pose risks of several complications due to their non-biodegradable nature. Here we present a fully bioresorbable epicardial pacing le...
Mineralized bone matrix attenuates breast cancer cell malignancy by altering MSC mechanoregulation [0.03%]
矿化骨基质通过改变间充质干细胞的机械感应来减弱乳腺癌细胞的恶性特征
Nicole Sempertegui,Yiwei Yan,Matthew A Whitman et al.
Nicole Sempertegui et al.
Bone metastasis, the leading cause of death in breast cancer patients with metastatic disease, initiates by early dissemination of cancer cells to osteogenic niches containing mineralizing collagen matrix and mesenchymal stem cells (MSCs). ...
Hydrogen-releasing electroactive nerve guidance conduits promote peripheral nerve regeneration by remodeling the microenvironment [0.03%]
释氢导电神经导管通过重塑微环境促进周围神经再生
Zhiqiang Li,Junwei Su,Xianzhen Dong et al.
Zhiqiang Li et al.
Following peripheral nerve injury (PNI), the early inflammatory response induces excessive production of reactive oxygen species (ROS), resulting in severe damage to the regenerative microenvironment, which poses a huge challenge to the aut...
Targeted tacrolimus delivery via manganese dioxide nanoparticles for mitigating acute allograft rejection in murine cardiac transplantation [0.03%]
锰酸盐纳米颗粒靶向输送他克莫司以缓解小鼠心脏移植急性排斥反应
Tao Liao,Xiaoyi Shi,Zhe Yang et al.
Tao Liao et al.
Cardiac transplantation is the preferred treatment option for patients with chronic heart failure. However, acute rejection remains as a the significant challenge that leads to cardiac allograft dysfunction, resulting from immune system act...
Human bone marrow niche organoids for disease modeling and therapeutic application in hematopoietic syndrome [0.03%]
人骨髓生态位类器官在造血综合征疾病建模和治疗应用中的作用
Heebin Park,Inseon Yu,Tae-Jin Kim et al.
Heebin Park et al.
Hematopoietic acute radiation syndrome (H-ARS) is a serious clinical condition caused by exposure to high-dose ionizing radiation that leads to the depletion of hematopoietic stem and progenitor cells with the collapse of the function of bo...