Bioactive nanocomposite hydrogel enhances postoperative immunotherapy and bone reconstruction for osteosarcoma treatment [0.03%]
用于骨肉瘤治疗的术后免疫疗法和骨重建的生物活性纳米复合水凝胶增强疗法
Xiangyu Chu,Bobin Mi,Yuan Xiong et al.
Xiangyu Chu et al.
Osteosarcoma, a malignant bone tumor often characterized by high hedgehog signaling activity, residual tumor cells, and substantial bone defects, poses significant challenges to both treatment response and postsurgical recovery. Here, we de...
Nano-enabled regulation of DNA damage in tumor cells to enhance neoantigen-based pancreatic cancer immunotherapy [0.03%]
基于纳米技术调控肿瘤细胞DNA损伤以增强新抗原胰腺癌免疫治疗
Jilong Wang,Chenghu Wu,Yiran Wang et al.
Jilong Wang et al.
Low-expression antigens, especially neoantigens, pose a significant challenge in immunotherapy for low immunogenicity pancreatic cancer. Increasing the tumor mutation burden is crucial to enhance the expression of tumor antigens and improve...
Targeted reprogramming of tumor-associated macrophages for overcoming glioblastoma resistance to chemotherapy and immunotherapy [0.03%]
靶向重编程肿瘤相关巨噬细胞以克服胶质母细胞瘤对化疗和免疫疗法的耐药性
Jianan Li,Jun Yang,Shaoping Jiang et al.
Jianan Li et al.
The resistance of glioblastoma multiforme (GBM) to standard chemotherapy is primarily attributed to the existence of tumor-associated macrophages (TAMs) in the GBM microenvironment, particularly the anti-inflammatory M2 phenotype. Targeted ...
Mingkai Chen,Junping Wang,Fei Cai et al.
Mingkai Chen et al.
Overexpression of thioredoxin reductase (TXNRD) plays crucial role in tumorigenesis. Therefore, designing TXNRD inhibitors is a promising strategy for targeted anticancer drug development. However, poor selectivity has always been a challen...
Injectable bioadhesive hydrogel as a local nanomedicine depot for targeted regulation of inflammation and ferroptosis in rheumatoid arthritis [0.03%]
一种可注射生物粘合水凝胶，作为局部纳米药物仓库，用于调节类风湿关节炎的炎症和铁死亡
Runze Yang,Liwei Yan,Tianhao Xu et al.
Runze Yang et al.
Medicine intervention is the major clinical treatment used to relieve the symptoms and delay the progression of rheumatoid arthritis (RA), but is limited by its poor targeted delivery and short therapeutic duration. Herein, we developed an ...
In situ customized apolipoprotein B48-enriched protein corona enhances oral gene delivery of chitosan-based nanoparticles [0.03%]
原位定制的富含载脂蛋白B48的蛋白质冠增强壳聚糖纳米粒子基因递送效果
Ziyun Lin,Shengqi Li,Qiuji Wu et al.
Ziyun Lin et al.
The formation of protein corona (PC) is important for promoting the in vivo delivery of nanoparticles (NPs). However, PC formed in the physiological environment of oral delivery is poorly understood. Here, we engineered seven types of trime...
Camouflaging nanoreactor traverse the blood-brain barrier to catalyze redox cascade for synergistic therapy of glioblastoma [0.03%]
隐身型纳米反应器催化体系穿越血脑屏障协同治疗胶质母细胞瘤
WeiYi Cheng,WeiYe Ren,Peng Ye et al.
WeiYi Cheng et al.
The blood-brain barrier (BBB) is a complex and highly restrictive barrier that prevents most biomolecules and drugs from entering the brain. However, effective strategies for delivering drugs to the brain are urgently needed for the treatme...
Hydrogel activation of Mincle receptors for tumor cell processing: A novel approach in cancer immunotherapy [0.03%]
用于肿瘤细胞处理的Mincb受体的水凝胶活化：癌症免疫治疗的新方法
Jiake Lin,Yuemin Zhou,Chen Li et al.
Jiake Lin et al.
An obstacle in current tumor immunotherapies lies in the challenge of achieving sustained and tumor-targeting T cell immunity, impeded by the limited antigen processing and cross-presentation of tumor antigens. Here, we propose a hydrogel-b...
Acoustic-holography-patterned primary hepatocytes possess liver functions [0.03%]
声全息图模式的原代肝细胞具备肝脏功能
Changcan Li,Gang Xu,Yinhan Wang et al.
Changcan Li et al.
Acoustic holography (AH), a promising approach for cell patterning, emerges as a powerful tool for constructing novel invitro 3D models that mimic organs and cancers features. However, understanding changes in cell function post-AH remains ...
CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity [0.03%]
基于离子脂质纳米颗粒的抗原和TLR7/8激动剂共递送诱导肿瘤保护性免疫反应
Tingting Ye,Zifu Zhong,Federica Cappellesso et al.
Tingting Ye et al.
Cancer vaccines aim at generating cytotoxic CD8+ T cells that kill cancer cells and confer durable tumor regression. Hereto, CD8+ peptide epitopes should be presented by antigen presenting cells to CD8+ T cells in lymphoid tissue. Unfortuna...