Peptide-based smart nanosystem for spatiotemporal regulation of bone immunity and cartilage repair to alleviate osteoarthritis [0.03%]
基于肽的智能纳米系统调控骨免疫和软骨修复以缓解骨关节炎
Yang Liu,Wenwei Li,Zhichao Yang et al.
Yang Liu et al.
The key pathological features of osteoarthritis (OA) are cartilage damage and synovial inflammation. However, traditional treatments often fail to mitigate the temporal and spatial progression of inflammation and cartilage damage, leading t...
Targeted delivery of apelin using a novel extracellular vesicle platform for pulmonary arterial hypertension treatment [0.03%]
用于肺动脉高压治疗的新型细胞外囊泡平台介导的血管活性肠肽靶向投递
Jihong Kim,Yong-Soon Choi,Jaehyun Kim et al.
Jihong Kim et al.
Pulmonary arterial hypertension (PAH) is a severe disease characterized by endothelial dysfunction, vascular remodeling, and pulmonary artery occlusion, culminating in right ventricular hypertrophy and heart failure. While apelin peptides a...
From injury to recovery: investigating wound healing in a 3D tissue-engineered cornea equivalent [0.03%]
从损伤到恢复：在三维组织工程角膜等效物中研究伤口愈合过程
Nicola Knetzger,Ann-Katrin Regensburger,Annika Goy et al.
Nicola Knetzger et al.
The semi-automatic generation of a multilayer cornea model was to study the process of wound healing and the influence of substances modulating wound healing. We generated in vitro corneal human tissues including epithelium and a semi autom...
Stable intermolecular charge-transfer nanocrystals as efficient immunogenic cell death adjuvants for photoimmunotherapy against trophoblastic and recurrent tumors [0.03%]
用于光免疫治疗胎盘间叶细胞瘤和复发性肿瘤的稳定分子间电荷转移纳米晶体诱导的高效免疫原性死亡佐剂
Yijian Gao,Zhongming Huang,Wenbin Chen et al.
Yijian Gao et al.
Organic photothermal agents (PTAs) with high-performance near-infrared properties hold great promise for precision phototherapy and bioimaging. The development of efficient PTAs depends mainly on advancements in molecular synthesis. However...
Modeling breast cancer dynamics through modulable small Vessel Environment Bioreactor (sVEB) [0.03%]
通过模块化小型血管环境生物反应器模拟乳腺癌动态
Fabio Maiullari,Maria Grazia Ceraolo,Dario Presutti et al.
Fabio Maiullari et al.
The development of advanced in vitro systems to replicate vascularized tissue environments is critical for studying cancer progression, immune interactions, and therapeutic responses. Traditional models often lack physiological perfusion, s...
Amplification of cGAS-STING pathway with "single-molecule multitarget" nanoparticles for chemo-immunotherapy of ovarian cancer [0.03%]
具有“单分子多重靶点”纳米颗粒的cGAS-STING通路放大化用于卵巢癌化疗免疫治疗
Huijiao Fu,Xue Liu,Feng Fang et al.
Huijiao Fu et al.
With a low autoimmune risk and dedicated induction of type Ⅰ interferon production in immunotherapy, "STING therapy" holds broad prospects in the treatment of aggressive and metastatic cancers such as ovarian cancer (OC). Inducing pyroptos...
AIE-active PVA/berberine antibacterial hydrogel for wound healing, visual monitoring pH and dehydration [0.03%]
用于伤口愈合和视觉监测的PVA/小檗碱抗菌水凝胶pH和脱水性能
Liqiang Gu,Xintao Sun,Jian Pan et al.
Liqiang Gu et al.
The antibacterial hydrogels have attracted a significant amount of interest for preventing bacterial infection in wound healing. However, irreversible antibiotic resistance and lagging detection of wound infection are still current research...
Mature biofilm-sensitive lysozyme-grafted Bi-guanidine backbone porphyrin nanorods for deep penetration and double phototherapy [0.03%]
一种用于深层渗透和双重光动力治疗的新型生物被膜敏感性溶菌酶修饰铋-胍类卟啉纳米棒抗生素替代物
Wenyan Yao,Tingya Wang,Wenyu Sun et al.
Wenyan Yao et al.
The efficacy of antibacterial therapy was largely vitiated because of the shield of bacteria by the intricate architecture of biofilms. For emerging phototherapy strategies like photothermal therapy (PTT) and photodynamic therapy (PDT), den...
Smart bioelectronic materials and systems for regenerative tissue engineering [0.03%]
用于再生组织工程的智能生物电子材料和系统
Sang Hoon Hong,Jin Huh,Ranjit De et al.
Sang Hoon Hong et al.
Regenerative medicine with stem cells has played a pivotal role in tissue engineering, demonstrating remarkable potential to address degenerative diseases and tissue deficiencies. Despite its great potential, this field faces significant ch...
Peritoneum-inspired adaptive hydrogel sheath orchestrating long-term lubrication and antibacterial properties for drainage tube intubation [0.03%]
一种适应性水凝胶鞘润滑和抗菌性能引导引流管插管长期润滑及抗菌性质的设计受腹膜启发
Zhi-Guo Wang,Ming Cai,Xue Xiao et al.
Zhi-Guo Wang et al.
Drainage tube (DT) intubation is frequently accompanied by distressing and even life-threatening complications. Herein, we engineer a peritoneum-inspired adaptive hydrogel sheath orchestrating long-term lubrication and broad-spectrum antiba...