Matthew J Goupell,Stephen Fong,Olga Stakhovskaya
Matthew J Goupell
An experiment was performed with 10 young normal-hearing listeners that attempted to determine if envelope modulations affected binaural processing in bandlimited pulse trains. Listeners detected an interaurally out-of-phase carrier pulse t...
Lateralization of virtual sound sources with a binaural cochlear-implant sound coding strategy inspired by the medial olivocochlear reflex [0.03%]
受中线橄榄耳蜗反向路径启发的双通道人工耳蜗声音编码策略在虚拟声源方位感上的优势
Enrique A Lopez-Poveda,Almudena Eustaquio-Martín,Milagros J Fumero et al.
Enrique A Lopez-Poveda et al.
Many users of bilateral cochlear implants (BiCIs) localize sound sources less accurately than do people with normal hearing. This may be partly due to using two independently functioning CIs with fixed compression, which distorts and/or red...
Expression of drug metabolizing enzymes and transporters in the cochlea: Implications for drug delivery and ototoxicity [0.03%]
耳蜗中药物代谢酶和转运体的表达：对药物递送和耳毒性的意义
Stefanie Kennon-McGill,Melissa M Clemens,Mitchell R McGill
Stefanie Kennon-McGill
Inner ear drug delivery is a major area of research and development, but relatively little is known about basic drug metabolism in the cochlea. Additionally, the use of potentially ototoxic drugs such as NSAIDs, chemotherapeutics and aminog...
Changes in auditory thalamus neural firing patterns after acoustic trauma in rats [0.03%]
噪声暴露后大鼠听觉丘脑神经元放电模式的改变
K M Barry,D Robertson,W H A M Mulders
K M Barry
Tinnitus is an abnormal phantom perception associated with cochlear trauma, and is thought to cause changes in the rates and patterns of firing neurons in the central auditory pathway. Recent studies have suggested a key role for the audito...
A humanized mouse model, demonstrating progressive hearing loss caused by MYO6 p.C442Y, is inherited in a semi-dominant pattern [0.03%]
MYO6 p.C442Y 导致进行性听力下降的人源化小鼠模型呈半显性遗传模式
Jinghan Wang,Jun Shen,Luo Guo et al.
Jinghan Wang et al.
Myosin VI is an actin-associated molecular motor vital for auditory and vestibular function. It is encoded by MYO6 located on chromosome 6q13 in human. Pathogenic variants in MYO6 have been associated with both dominant and recessive forms ...
Donna S Whitlon,Hunter Young,Mark Barna et al.
Donna S Whitlon et al.
Across the world, dozens of outbred Hartley guinea pig stocks are used for auditory experiments. The genetic makeup of these different stocks will differ due to differences in breeding protocols, history and genetic drift. In fact, outbred ...
The TLR-4/NF-κB signaling pathway activation in cochlear inflammation of rats with noise-induced hearing loss [0.03%]
噪声性听力损失大鼠耳蜗炎症TLR-4/ NF-κB信号通路激活作用研究
Guoping Zhang,Hongliang Zheng,Ilmari Pyykko et al.
Guoping Zhang et al.
The TLR-4/NF-κB signaling pathway is involved in innate immunity and inflammation induced by trauma. The present study aimed to investigate possible TLR-4/NF-κB signaling pathway activation in the cochlea associated with acoustic trauma t...
Gregory M Ellis,Pavel Zahorik
Gregory M Ellis
As direct-to-reverberant energy ratio (DRR) decreases or decay time increases, speech intelligibility tends to decrease for both normal-hearing and hearing-impaired listeners. Given this relationship, it is easy to assume that perceived rev...
Noise-induced hearing loss alters hippocampal glucocorticoid receptor expression in rats [0.03%]
噪声性听力损失影响大鼠海马糖皮质激素受体表达
Sarah H Hayes,Senthilvelan Manohar,Antara Majumdar et al.
Sarah H Hayes et al.
Although the effects of intense noise exposure on the peripheral and central auditory pathway have been well characterized, its effects on non-classical auditory structures in the brain, such as the hippocampus, are less well understood. Pr...
EEG rhythms lateralization patterns in children with unilateral hearing loss are different from the patterns of normal hearing controls during speech-in-noise listening [0.03%]
单侧听力损失儿童在噪声环境中听取言语时的脑电节律侧化模式与正常听力对照组不同
Giulia Cartocci,Alessandro Scorpecci,Gianluca Borghini et al.
Giulia Cartocci et al.
Unilateral hearing loss constitutes a field of growing interest in the scientific community. In fact, this kind of patients represent a unique and physiological way to investigate how neuroplasticity overcame unilateral deafferentation by i...