Next generation sequencing study in a cohort of Italian patients with syndromic hearing loss [0.03%]
意大利综合征性听力损失患者的下一代测序研究
Stefania Lenarduzzi,Anna Morgan,Flavio Faletra et al.
Stefania Lenarduzzi et al.
Hearing loss (HL), one of the most common congenital disorder, affects about one child in 1000. Among the genetic forms of HL, ∼30% of the cases are associated with other signs or symptoms, leading to Syndromic Hearing Loss (SHL) with abou...
Please try harder! The influence of hearing status and evaluative feedback during listening on the pupil dilation response, saliva-cortisol and saliva alpha-amylase levels [0.03%]
请再努力一些！听力状况和听取过程中的评判性反馈对瞳孔扩张反应、唾液皮质醇水平及唾液淀粉酶水平的影响
Adriana A Zekveld,Johanna A M van Scheepen,Niek J Versfeld et al.
Adriana A Zekveld et al.
The pupil dilation response is sensitive both to listening effort and the emotional significance of a task. We aimed to assess the influence of evaluative feedback on the pupil dilation response using a speech reception threshold (SRT) task...
Please try harder! The influence of hearing status and evaluative feedback during listening on the pupil dilation response, saliva-cortisol and saliva alpha-amylase levels [0.03%]
请更努力一些！听力状况及听说过程中的评价反馈对 pupils 放大反应、唾液皮质醇和唾液淀粉酶的影响
Adriana A Zekveld,Johanna A M van Scheepen,Niek J Versfeld et al.
Adriana A Zekveld et al.
The pupil dilation response is sensitive both to listening effort and the emotional significance of a task. We aimed to assess the influence of evaluative feedback on the pupil dilation response using a speech reception threshold (SRT) task...
A novel microneedle device for controlled and reliable liquid biopsy of the human inner ear [0.03%]
一种新型微针设备，用于人类内耳受控且可靠的液体活检
Samuel Early,In Seok Moon,Krishna Bommakanti et al.
Samuel Early et al.
Sensorineural hearing loss is the most common sensory deficit worldwide, yet our understanding of the underlying pathophysiology is limited by the challenges of access to the inner ear in a safe and reliable manner. We present a novel micro...
Measuring temporal response properties of auditory nerve fibers in cochlear implant recipients [0.03%]
测定人工耳蜗植入者听神经纤维的时序响应性质
Sonia Tabibi,Andrea Kegel,Wai Kong Lai et al.
Sonia Tabibi et al.
Auditory nerve fibers' (ANFs) refractoriness and facilitation can be quantified in electrically evoked compound action potentials (ECAPs) recorded via neural response telemetry (NRT). Although facilitation has been observed in animals and h...
Early phase trials of novel hearing therapeutics: Avenues and opportunities [0.03%]
新型听力治疗药物一期临床试验：现状与展望
Anne G M Schilder,Matthew P Su,Rishi Mandavia et al.
Anne G M Schilder et al.
Novel hearing therapeutics are rapidly progressing along the innovation pathway and into the clinical trial domain. Because these trials are new to the hearing community, they come with challenges in terms of trial design, regulation and de...
Sex differences in subcortical auditory processing emerge across development [0.03%]
性别差异在皮层下听觉处理中的发展变化
Jennifer Krizman,Silvia Bonacina,Nina Kraus
Jennifer Krizman
Human subcortical auditory processing is sexually dimorphic. The prevailing view - that sex differences arise from cochlear differences - remains unproven, and the extent to which these differences reflect distinct auditory processes is unk...
Comparative Study
Hearing research. 2019 Sep 1:380:166-174. DOI:10.1016/j.heares.2019.07.002 2019
Applicability of subcortical EEG metrics of synaptopathy to older listeners with impaired audiograms [0.03%]
脑电图指标在老年听力受损患者中的适用性研究
Markus Garrett,Sarah Verhulst
Markus Garrett
Emerging evidence suggests that cochlear synaptopathy is a common feature of sensorineural hearing loss, but it is not known to what extent electrophysiological metrics targeting synaptopathy in animals can be applied to people, such as tho...
Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes [0.03%]
电转染神经生长因子基因以改善人工耳蜗的听觉效果
Jeremy L Pinyon,Georg von Jonquieres,Edward N Crawford et al.
Jeremy L Pinyon et al.
This Review outlines the development of DNA-based therapeutics for treatment of hearing loss, and in particular, considers the potential to utilize the properties of recombinant neurotrophins to improve cochlear auditory (spiral ganglion) n...
Brainstem encoding of frequency-modulated sweeps is relevant to Mandarin concurrent-vowels identification for normal-hearing and hearing-impaired listeners [0.03%]
频率调制扫频的脑干编码与正常听力和听力受损者识别普通话共振音的关系密切相关
Zhen Fu,Hongying Yang,Fei Chen et al.
Zhen Fu et al.
F0 contours convey the primary information of lexical Tones for Mandarin Chinese, and the processing of time-varying F0 contours is important for Mandarin concurrent-vowels identification (MCVI). In this work, we examined the relationship b...