Gene therapy for genetic mutations affecting non-sensory cells in the cochlea [0.03%]
耳蜗基因治疗靶向非感觉细胞中的遗传突变
Li Zhang,Xuewen Wu,Xi Lin
Li Zhang
Congenital hearing loss (HL) affects about 1 in every 500 infants. Among those affected more than half are caused by genetic mutations. According to the cellular sites affected by mutations in the cochlea, deafness genes could be classified...
Contribution of spectral pinna cues for sound localization in children with congenital unilateral conductive hearing loss after hearing rehabilitation [0.03%]
儿童先天性单侧传导性听力损失术后谱 PINNA 声源定位线索的贡献
Katharina Vogt,Jan-Willem Wasmann,A John Van Opstal et al.
Katharina Vogt et al.
Congenital unilateral conductive hearing loss (UCHL) jeopardizes directional hearing and speech perception in noisy conditions. Potentially, children with congenital UCHL can benefit from fitting a hearing device, such as a bone-conduction ...
Nanomechanical mapping reveals localized stiffening of the basilar membrane after cochlear implantation [0.03%]
纳米机械测量揭示耳蜗植入后基底膜局部硬化现象
Jessica K Choong,Amy J Hampson,Kate M Brody et al.
Jessica K Choong et al.
Cochlear implantation leads to many structural changes within the cochlea which can impair residual hearing. In patients with preserved low-frequency hearing, a delayed hearing loss can occur weeks-to-years post-implantation. We explore whe...
Amino acid and acetylcholine chemistry in mountain beaver cochlear nucleus and comparisons to pocket gopher, other rodents, and cat [0.03%]
山 Beaver 听觉神经核中的氨基酸和乙酰胆碱化学及与其他啮齿动物和猫的比较
Donald A Godfrey,Nikki L Mikesell,Timothy G Godfrey et al.
Donald A Godfrey et al.
The mountain beaver and pocket gopher are two rodents that live mostly underground in tunnel systems. Previous studies have suggested that their cochlear nucleus structure, particularly that of the dorsal cochlear nucleus (DCN), differs sig...
Comparative Study
Hearing research. 2020 Jan:385:107841. DOI:10.1016/j.heares.2019.107841
Modeling the characteristics of spontaneous otoacoustic emissions in lizards [0.03%]
lizard耳自发性声发射的特征建模
Hero P Wit,Geoffrey A Manley,P van Dijk
Hero P Wit
Lizard auditory papillae have proven to be an attractive object for modelling the production of spontaneous otoacoustic emissions (SOAE). Here we use an established model (Vilfan and Duke, 2008) and extend it by exploring the effect of vary...
Paired measurements of cochlear function and hair cell count in Dutch-belted rabbits with noise-induced hearing loss [0.03%]
噪声引起的听力损失的荷兰背兔耳蜗功能配对测定和毛细胞计数
Hariprakash Haragopal,Ryan Dorkoski,Holly M Johnson et al.
Hariprakash Haragopal et al.
The effects of noise-induced hearing loss have yet to be studied for the Dutch-belted strain of rabbits, which is the only strain that has been used in studies of the central auditory system. We measured auditory brainstem responses (ABRs),...
Comparative Study
Hearing research. 2020 Jan:385:107845. DOI:10.1016/j.heares.2019.107845
Vascular endothelial growth factor is required for regeneration of auditory hair cells in the avian inner ear [0.03%]
血管内皮生长因子是鸟类内耳听觉毛细胞再生所必需的
Liangcai Wan,Michael Lovett,Mark E Warchol et al.
Liangcai Wan et al.
Hair cells in the auditory organ of the vertebrate inner ear are the sensory receptors that convert acoustic stimuli into electrical signals that are conveyed along the auditory nerve to the brainstem. Hair cells are highly susceptible to o...
Neuronal sensitivity to the interaural time difference of the sound envelope in the mouse inferior colliculus [0.03%]
小鼠下丘听觉神经元对声音包络期差的敏感性
Munenori Ono,Deborah C Bishop,Douglas L Oliver
Munenori Ono
We examined the sensitivity of the neurons in the mouse inferior colliculus (IC) to the interaural time differences (ITD) conveyed in the sound envelope. Utilizing optogenetic methods, we compared the responses to the ITD in the envelope of...
Comparative Study
Hearing research. 2020 Jan:385:107844. DOI:10.1016/j.heares.2019.107844
Atoh1 is required in supporting cells for regeneration of vestibular hair cells in adult mice [0.03%]
Atoh1在维持和支持小鼠成年耳蜗支撑细胞介导的毛细胞再生中的作用
Kelli L Hicks,Serena R Wisner,Brandon C Cox et al.
Kelli L Hicks et al.
In amniotes, head movements are encoded by two types of vestibular hair cells (type I and type II) with unique morphology, physiology, and innervation. After hair cell destruction in mature rodents, supporting cells regenerate some type II ...
Topography of vibration frequency responses on the bony tympano-periotic complex of the pilot whale Globicephala macrorhynchus [0.03%]
宽吻 pilot鲸骨 tympanoperiotics结构振动频率的拓扑特征研究
Itamar Tsur,Nir Shaviv,Israel Bronstein et al.
Itamar Tsur et al.
In modern Cetacea, the ear bone complex comprises the tympanic and periotic bones forming the tympano-periotic complex (TPC), differing from temporal bone complexes of other mammals in form, construction, position, and possibly function. To...
Comparative Study
Hearing research. 2019 Dec:384:107810. DOI:10.1016/j.heares.2019.107810