Evidence for gene-smoking interactions for hearing loss and deafness in Japanese American families [0.03%]
日本美国人家庭中听觉丧失和耳聋的基因-吸烟交互作用证据
Jia Y Wan,Christina Cataby,Andrew Liem et al.
Jia Y Wan et al.
Background: This study investigated the relationship between smoking and hearing loss and deafness (HLD) and whether the relationship is modified by genetic variation. Data for these analyses was from the subset of Japane...
Morphometric linear and angular measurements of the human cochlea in implant patients using 3-dimensional reconstruction [0.03%]
听植入患者人工耳蜗三维重建的线性和角度测量
Arman Danielian,Gail Ishiyama,Ivan A Lopez et al.
Arman Danielian et al.
The present study is the first to evaluate the spiral ganglion neurons (SGNs) and the linear and angular measurements of the cochlea in temporal bones of cochlear implant (CI) recipients. There are no studies evaluating the morphometric mea...
Psychoacoustic and electrophysiological electric-acoustic interaction effects in cochlear implant users with ipsilateral residual hearing [0.03%]
单侧残余听力人工耳蜗植入者的心理声学和电生理的电-声交互作用效应
Marina Imsiecke,Andreas Büchner,Thomas Lenarz et al.
Marina Imsiecke et al.
Cochlear implant users with ipsilateral residual hearing combine acoustic and electric hearing in one ear, this is called electric-acoustic stimulation (EAS). In EAS users, masking can be shown for electric probes in the presence of acousti...
Differential cortical and subcortical projection targets of subfields in the core region of mouse auditory cortex [0.03%]
小鼠听皮层核心区亚分区的皮层和亚皮层投射目标的差异性
Shiro Nakata,Makoto Takemoto,Wen-Jie Song
Shiro Nakata
The core region of the rodent auditory cortex has two areas: the primary auditory area (A1) and the anterior auditory field (AAF). However, the functional difference between these areas is unclear. To elucidate this issue, here we studied t...
Comparative Study
Hearing research. 2020 Feb:386:107876. DOI:10.1016/j.heares.2019.107876 2020
Alvaro Gallego-Martinez,Jose A Lopez-Escamez
Alvaro Gallego-Martinez
Meniere's disease (MD) is a complex disorder of the inner ear that causes vertigo attacks, fluctuating sensorineural hearing loss (SNHL), tinnitus and aural fullness. MD has been attributed to an accumulation of endolymph in the cochlear du...
P2RX2 and P2RX4 receptors mediate cation absorption in transitional cells and supporting cells of the utricular macula [0.03%]
P2RX2和P2RX4受体介导过渡细胞和支持细胞的离子吸收：乌廷斑马鱼耳膜上皮的案例研究
Junhui Jeong,Jin Young Kim,Hansol Hong et al.
Junhui Jeong et al.
Purinergic receptors protect the cochlea during high-intensity stimulation by providing a parallel shunt pathway through non-sensory neighboring epithelial cells for cation absorption. So far, there is no direct functional evidence for the ...
Intravenously delivered aminoglycoside antibiotics, tobramycin and amikacin, are not ototoxic in mice [0.03%]
静脉注射的氨基糖苷类抗生素 Tobramycin 和 Amikacin 在小鼠中不具有耳毒性
Jacqueline M Ogier,Paul J Lockhart,Rachel A Burt
Jacqueline M Ogier
Many drugs on the World Health Organization's list of critical medicines are ototoxic, destroying sensory hair cells within the ear. These drugs preserve life, but patients can experience side effects including permanent hearing loss and ve...
Associations between tinnitus and glaucoma suggest a common mechanism: A clinical and population-based study [0.03%]
耳鸣和青光眼之间的关联表明存在共同的发病机制：临床研究与流行病学研究
Allison R Loiselle,Anna Neustaeter,Emile de Kleine et al.
Allison R Loiselle et al.
The purpose of this study was to determine if there is an association between tinnitus and glaucoma. We tested this by first completing a clinic-based cross-sectional questionnaire study in which we sent a series of tinnitus-related questio...
Novel insights into inner ear development and regeneration for targeted hearing loss therapies [0.03%]
内耳发育和再生的新见解及其在靶向治疗听力损失中的应用
Marta Roccio,Pascal Senn,Stefan Heller
Marta Roccio
Sensorineural hearing loss is the most common sensory deficit in humans. Despite the global scale of the problem, only limited treatment options are available today. The mammalian inner ear is a highly specialized postmitotic organ, which l...
Ellen Reisinger
Ellen Reisinger
Adeno-associated viruses (AAVs) are preferred vectors for gene replacement therapy, as they are non-pathogenic, non-inflammatory, induce stable transgene expression in terminally differentiated cells, and a series of natural and engineered ...