Noise-induced hearing loss in zebrafish: investigating structural and functional inner ear damage and recovery [0.03%]
斑马鱼噪声性听力损失：探究内耳结构与功能的损伤及恢复情况
Lukas Breitzler,Ieng Hou Lau,Paulo J Fonseca et al.
Lukas Breitzler et al.
Exposure to continuous moderate noise levels is known to impair the auditory system leading to Noise-Induced Hearing Loss (NIHL) in animals including humans. The mechanism underlying noise-dependent auditory Temporary Threshold Shifts (TTS)...
Formant frequency discrimination with a fine structure sound coding strategy for cochlear implants [0.03%]
精细结构编码策略下的调频频率辨别力研究
R Liepins,A Kaider,C Honeder et al.
R Liepins et al.
Recent sound coding strategies for cochlear implants (CI) have focused on the transmission of temporal fine structure to the CI recipient. To date, knowledge about the effects of fine structure coding in electrical hearing is poorly charact...
Philipp Niggemann,Bence György,Zheng-Yi Chen
Philipp Niggemann
Genome editing opens up a new frontier in developing personalized therapeutic solutions. With the unprecedented advance in the discovery and engineering of gene editing nucleases, it has now become potentially feasible to therapeutically in...
The ongoing search for cochlear synaptopathy in humans: Masked thresholds for brief tones in Threshold Equalizing Noise [0.03%]
人耳蜗突触病的持续性搜索：阈值平衡噪声下短声信号的掩蔽阂值研究
Frederic Marmel,Daniela Cortese,Karolina Kluk
Frederic Marmel
This study aimed to advance towards a clinical diagnostic method for detection of cochlear synaptopathy with the hypothesis that synaptopathy should be manifested in elevated masked thresholds for brief tones. This hypothesis was tested in ...
Neurotrophin gene therapy to promote survival of spiral ganglion neurons after deafness [0.03%]
神经生长因子基因治疗促进耳聋后的螺旋神经节神经元存活
Patricia A Leake,Omar Akil,Hainan Lang
Patricia A Leake
Hearing impairment is a major health and economic concern worldwide. Currently, the cochlear implant (CI) is the standard of care for remediation of severe to profound hearing loss, and in general, contemporary CIs are highly successful. Bu...
Uncertainty-based informational masking in a vowel discrimination task for young and old Mongolian gerbils [0.03%]
基于不确定性的信息掩蔽在年轻和年老蒙古沙鼠的元音辨别任务中的作用
Lena Eipert,Georg M Klump
Lena Eipert
Informational masking emerges with processing of complex sounds in the central auditory system and can be affected by uncertainty emerging from trial-to-trial variation of stimulus features. Uncertainty can be non-informative but confusing ...
Comparative Study
Hearing research. 2020 Jul:392:107959. DOI:10.1016/j.heares.2020.107959 2020
The effect of a coding strategy that removes temporally masked pulses on speech perception by cochlear implant users [0.03%]
一种去除受时间掩蔽影响的脉冲的编码策略对 Cochlear 移植用户的言语感知的影响研究
Wiebke Lamping,Tobias Goehring,Jeremy Marozeau et al.
Wiebke Lamping et al.
Speech recognition in noisy environments remains a challenge for cochlear implant (CI) recipients. Unwanted charge interactions between current pulses, both within and between electrode channels, are likely to impair performance. Here we in...
X-ray fluorescence microscopy: A method of measuring ion concentrations in the ear [0.03%]
x射线荧光显微镜：测量耳内离子浓度的一种方法
Eileen Y Brister,Zahra Vasi,Olga Antipova et al.
Eileen Y Brister et al.
This technical note describes synchrotron x-ray fluorescence microscopy (XFM) as a method for measuring the concentrations of different elements in cross-sections of the ear at extremely high resolution. This method could be of great import...
Acoustic trauma induced the alteration of the activity balance of excitatory and inhibitory neurons in the inferior colliculus of mice [0.03%]
噪声性听力损伤致小鼠下丘神经元兴奋抑制平衡失调
Lanlan Ma,Munenori Ono,Ling Qin et al.
Lanlan Ma et al.
We examined the effect of acoustic trauma on the spontaneous activities of the glutamatergic and GABAergic neurons in the inferior colliculus (IC) of mice. Optogenetics was used to identify the neuron type. In control animals, the spontaneo...
Loss of inner hair cell ribbon synapses and auditory nerve fiber regression in Cldn14 knockout mice [0.03%]
Cldn14敲除小鼠内毛细胞突触连接和听神经纤维的缺失
Maike Claußen,Jennifer Schulze,Hans Gerd Nothwang
Maike Claußen
Proper functioning of the auditory nerve is of critical importance for auditory rehabilitation by cochlear implants. Here we used the Cldn14-/- mouse to study in detail the effects of Claudin 14 loss on auditory synapses and the auditory ne...