Amanda M Lauer,Sergio Vicencio Jimenez,Paul H Delano
Amanda M Lauer
The role of the mammalian auditory olivocochlear efferent system in hearing has long been the subject of debate. Its ability to protect against damaging noise exposure is clear, but whether or not this is the primary function of a system th...
Expression of a membrane-targeted fluorescent reporter disrupts auditory hair cell mechanoelectrical transduction and causes profound deafness [0.03%]
膜定位荧光报告蛋白表达干扰听觉毛细胞机械电转导并导致重度耳聋
Angela Ballesteros,Tracy S Fitzgerald,Kenton J Swartz
Angela Ballesteros
The reporter mT/mG mice expressing a membrane-targeted fluorescent protein are becoming widely used to study the auditory and vestibular system due to its versatility. Here we show that high expression levels of the fluorescent mtdTomato re...
The perception of octave pitch affinity and harmonic fusion have a common origin [0.03%]
八度音高亲和力与泛音融合感知同源
Laurent Demany,Guilherme Monteiro,Catherine Semal et al.
Laurent Demany et al.
Musicians say that the pitches of tones with a frequency ratio of 2:1 (one octave) have a distinctive affinity, even if the tones do not have common spectral components. It has been suggested, however, that this affinity judgment has no bio...
Frequency following responses and rate change complexes in cochlear implant users [0.03%]
植入人工耳蜗用户的频率跟随反应和速率变化复合体
Robin Gransier,Franҫois Guérit,Robert P Carlyon et al.
Robin Gransier et al.
The upper limit of rate-based pitch perception and rate discrimination can differ substantially across cochlear implant (CI) users. One potential reason for this difference is the presence of a biological limitation on temporal encoding in ...
Li Li,Xiaopeng Liu,Guang-Di Chen et al.
Li Li et al.
The effect of intense noise on cochlear sensitivity has been extensively studied, but its influence on the temporal characteristics of the cochlear response is still unclear. This study investigated the effects of noise exposure on the late...
Kali Burke,Senthilvelan Manohar,Micheal L Dent
Kali Burke
Blast trauma is a common acoustic/physical insult occurring in modern warfare. Twenty percent of active duty military come into close proximity to explosions and experience mild to severe sensory deficits. The prevalence of such injuries is...
A clinically derived guinea pig dosing model of cisplatin ototoxicity [0.03%]
基于临床的顺铂致 Guinea 猪耳毒性的剂量模型研究
James K Stanford,Nicholas A Bosworth,Drew S Morgan et al.
James K Stanford et al.
The guinea pig is a commonly-used animal model in hearing research, as their audible frequency range is similar to that of humans, and they possess comparatively large cochleae among rodents. Numerous studies have investigated the ototoxic ...
Changing the time intervals between cisplatin cycles alter its ototoxic side effect [0.03%]
顺铂用药周期之间的时间间隔改变会影响其耳毒性副作用
Eric C Bielefeld,Alicia Gonzalez,J Riley DeBacker
Eric C Bielefeld
Various methods have been tested and deployed clinically to identify and minimize cisplatin ototoxicity. Upon early identification of hearing loss, one of the possible approaches to reducing future ototoxicity is to increase the gaps or bre...
Fabrication of human anatomy-based scala tympani models with a hydrophilic coating for cochlear implant insertion experiments [0.03%]
基于人体解剖的耳蜗植入物插入实验用水合涂层制作鼓室阶模型
Philipp Aebischer,Marco Caversaccio,Wilhelm Wimmer
Philipp Aebischer
Electrode array insertion into the inner ear is a critical step in cochlear implantation, and artificial scala tympani models can be a valuable tool for studying the dynamics of this process. This technical note describes the fabrication of...
Neuroplastic changes in auditory cortex induced by long-duration "non-traumatic" noise exposures are triggered by deficits in the neural output of the cochlea [0.03%]
由耳蜗神经输出缺陷引发的长时间“非创伤性”噪声暴露引起的听觉皮层神经可塑性变化
Xiaopeng Liu,Guang-Di Chen,Richard Salvi
Xiaopeng Liu
Long-term exposure to moderate intensity noise that does not cause measureable hearing loss can cause striking changes in sound-evoked neural activity in auditory cortex. It is unclear if these changes originate in the cortex or result from...