Deafness in an auditory specialist, the big brown bat (Eptesicus fuscus) [0.03%]
听觉专家大褐蝙蝠(Eptesicus fuscus)的耳聋问题
Madison M Weinberg,Nazrawit A Retta,Katrina M Schrode et al.
Madison M Weinberg et al.
Bats are long-lived animals that show presumed resistance to noise-induced and age-related hearing loss, which has been attributed to their dependence on sound processing for survival. Echolocation and basic auditory functions have been stu...
LCCL peptide cleavage after noise exposure exacerbates hearing loss and is associated with the monocyte infiltration in the cochlea [0.03%]
噪声暴露后LCCL肽段的裂解通过加剧听力损失并与耳蜗中单核细胞浸润有关
Seong Hoon Bae,Jee Eun Yoo,Ji Won Hong et al.
Seong Hoon Bae et al.
Acoustic trauma induces an inflammatory response in the cochlea, resulting in debilitating hearing function. Clinically, amelioration of inflammation substantially prevents noise-induced hearing loss. The Limulus factor C, Cochlin, and Lgl1...
Output performance of the novel active transcutaneous bone conduction implant Sentio at different stimulation sites [0.03%]
全新主动式经皮骨传导植入装置Sentio在不同刺激位点的输出效果研究
Mohammad Ghoncheh,Stefan Stenfelt,Patrick Maas et al.
Mohammad Ghoncheh et al.
Objectives: The output performance of a novel semi-implantable transcutaneous bone conduction device was compared to an established percutaneous bone-anchored hearing system device using cadaver heads. The influence of ac...
Electrical impedance guides electrode array in cochlear implantation using machine learning and robotic feeder [0.03%]
电阻抗指导 cochlear 植入中的电极阵列使用机器学习和机器人供料器
Nauman Hafeez,Xinli Du,Nikolaos Boulgouris et al.
Nauman Hafeez et al.
Cochlear Implant provides an electronic substitute for hearing to severely or profoundly deaf patients. However, postoperative hearing outcomes significantly depend on the proper placement of electrode array (EA) into scala tympani (ST) dur...
Rectifying and sluggish: Outer hair cells as regulators rather than amplifiers [0.03%]
纠正式与迟缓式：外毛细胞是调节者而非放大器
Marcel van der Heijden,Anna Vavakou
Marcel van der Heijden
In the cochlea, mechano-electrical transduction is preceded by dynamic range compression. Outer hair cells (OHCs) and their voltage dependent length changes, known as electromotility, play a central role in this compression process, but the...
Systemic toll-like receptor 9 agonist CpG oligodeoxynucleotides exacerbates aminoglycoside ototoxicity [0.03%]
系统性Toll样受体9激动剂CpG寡脱氧核苷酸加重氨基糖苷类抗生素的耳毒性
Chao-Hui Yang,Chung-Feng Hwang,Jiin-Haur Chuang et al.
Chao-Hui Yang et al.
The Toll-like receptor (TLR) signaling pathway is the key regulator of the innate immune system in response to systemic infection. Several studies have reported that the systemic TLR4 agonist lipopolysaccharide exacerbates aminoglycoside ot...
Athanasia Warnecke,Odett Kaiser,Thomas Lenarz
Athanasia Warnecke
Ronald Pouyo,Keshi Chung,Laurence Delacroix et al.
Ronald Pouyo et al.
Post-translational modifications of proteins are essential for the proper development and function of many tissues and organs, including the inner ear. Ubiquitination is a highly selective post-translational modification that involves the c...
A retrospective cross-sectional study on tinnitus prevalence and disease associations in the Dutch population-based cohort Lifelines [0.03%]
荷兰人口队列Lifelines中耳鸣发病率及疾病关联的回顾性横断面研究
Nick M A Schubert,Judith G M Rosmalen,Pim van Dijk et al.
Nick M A Schubert et al.
Tinnitus is a highly prevalent disorder with heterogenous presentation and limited treatment options. Better understanding of its prevalence and disease and lifestyle risk factor associations in the general population is necessary to identi...
Excitotoxic damage to auditory nerve afferents and spiral ganglion neurons is correlated with developmental upregulation of AMPA and KA receptors [0.03%]
与发育相关的AMPA和KA受体的上调与听神经传入和螺旋神经节神经元的兴奋性毒性损伤相关
Dalian Ding,Weidong Qi,Haiyan Jiang et al.
Dalian Ding et al.
Excess release of glutamate at the inner hair cell-type I auditory nerve synapse results in excitotoxicity characterized by rapid swelling and disintegration of the afferent synapses, but in some cases, the damage expands to the spiral gang...