Joseph Santos-Sacchi,Dhasakumar Navaratnam
Joseph Santos-Sacchi
The outer hair cell (OHC) is celebrated on the 21st birthday of prestin's identification and the year of this molecular motor's sub-nanometer structural solution. Dogmatic conceptions of OHC performance have been challenged by decades of bi...
Inner ear immunity [0.03%]
内耳免疫系统
Elizabeth M Keithley
Elizabeth M Keithley
The inner ear, like all organs, interacts with the systemic immune system via lymphatic drainage and vascular circulation to protect itself from infections and stress such as acoustic trauma. The adult mammalian inner ear including the endo...
Conditional overexpression of neuritin in supporting cells (SCs) mitigates hair cell (HC) damage and induces HC regeneration in the adult mouse cochlea after drug-induced ototoxicity [0.03%]
条件性过表达神经抑素可减轻成年小鼠耳毒性损伤后的支持细胞和毛细胞损伤并诱导毛细胞再生
Juan Huang,Xiaopin Sun,Haiyan Wang et al.
Juan Huang et al.
Hearing loss due to the loss of auditory hair cells is normally irreversible because mammalian hair cells do not regenerate. Using neurotrophic factors to induce the regeneration of hair cells (HCs) from adjacent nonsensory supporting cells...
Contraction of the stapedius and tensor tympani muscles explored by tympanometry and pressure measurement in the external auditory canal [0.03%]
利用声导抗和外耳道压力测量法探索鼓索肌和鼓膜张肌的收缩反应
Philippe Fournier,Sébastien Paquette,Dany Paleressompoulle et al.
Philippe Fournier et al.
It has been suggested that tensor tympani muscle (TTM) contraction may be involved in the development of ear-related pathologies such as tinnitus, hyperacusis and otalgia, called the tonic tensor tympani syndrome (TTTS). However, as there i...
Cisplatin exposure acutely disrupts mitochondrial bioenergetics in the zebrafish lateral-line organ [0.03%]
顺铂暴露急性扰乱斑马鱼侧线器官的线粒体生物能量学
David S Lee,Angela Schrader,Mark Warchol et al.
David S Lee et al.
Cisplatin is a commonly used chemotherapeutic agent that causes debilitating high-frequency hearing loss. No targeted therapies currently exist to treat cisplatin ototoxicity, partly because the underlying mechanisms of cisplatin-induced ha...
Chronic cochlear implantation with and without electric stimulation in a mouse model induces robust cochlear influx of CX3CR1+/GFP macrophages [0.03%]
小鼠慢性耳蜗植入模型中，有或无电刺激均会导致携带CX3CR1+/GFP的耳蜗巨噬细胞大量涌入
Alexander D Claussen,René Vielman Quevedo,Jonathon R Kirk et al.
Alexander D Claussen et al.
Background: Cochlear implantation is an effective auditory rehabilitation strategy for those with profound hearing loss, including those with residual low frequency hearing through use of hybrid cochlear implantation tech...
Samuel Early,Eric Du,Ely Boussaty et al.
Samuel Early et al.
Hearing loss is the most common sensory deficit worldwide, with the majority of preventable injury attributed to noise-induced hearing loss (NIHL). Highly conserved cochlear genetics between humans and mice have made this animal model a hig...
Perceptual spatial position induces the attentional enhancement of prepulse inhibition and its neural mechanism [0.03%]
感知性空间位置诱导prepulse抑制的注意增强及其神经机制
Langjie Chen,Lei Liu,Zhongshu Ge et al.
Langjie Chen et al.
Prepulse inhibition (PPI) is a sensorimotor gating process that reduces the startling response when a weaker sensory stimulus precedes a sudden startling stimulus. Perceptual spatial separation (PSS) between the prepulse and the background ...
Sabine Reinfeldt,Måns Eeg-Olofsson,Karl-Johan Fredén Jansson et al.
Sabine Reinfeldt et al.
Active transcutaneous bone conduction devices are a type of bone conduction device developed to keep the skin intact and provide direct bone conduction stimulation. The Bone Conduction Implant (BCI) is such a device and has been implanted i...
Modelling speech reception thresholds and their improvements due to spatial noise reduction algorithms in bimodal cochlear implant users [0.03%]
听觉脑干植入信号掩蔽模型及空间降噪算法改善效果研究
Ayham Zedan,Tim Jürgens,Ben Williges et al.
Ayham Zedan et al.
Spatial noise reduction algorithms ("beamformers") can considerably improve speech reception thresholds (SRTs) for bimodal cochlear implant (CI) users. The goal of this study was to model SRTs and SRT-benefit due to beamformers for bimodal ...