Christof Röösli,Stefan Stenfelt
Christof Röösli
Altering gene expression using antisense oligonucleotide therapy for hearing loss [0.03%]
反义寡核苷酸疗法用于听力损失的基因表达调控
Katelyn N Robillard,Erik de Vrieze,Erwin van Wijk et al.
Katelyn N Robillard et al.
Hearing loss affects more than 430 million people, worldwide, and is the third most common chronic physical condition in the United States and Europe (GBD Hearing Loss Collaborators, 2021; NIOSH, 2021; WHO, 2021). The loss of hearing signif...
Exploring the middle ear function in patients with a cluster of symptoms including tinnitus, hyperacusis, ear fullness and/or pain [0.03%]
耳鸣、响度重反应、耳闷和/或耳痛等症状患者中耳功能的探讨研究
Philippe Fournier,Dany Paleressompoulle,Marie-José Esteve Fraysse et al.
Philippe Fournier et al.
Middle ear muscle (MEM) abnormalities have been proposed to be involved in the development of ear-related symptoms such as tinnitus, hyperacusis, ear fullness, dizziness and/or otalgia. This cluster of symptoms have been called the Tonic Te...
Ablation of Liver X receptor β in mice leads to overactive macrophages and death of spiral ganglion neurons [0.03%]
小鼠肝脏X受体β缺乏导致巨噬细胞活化过度和螺旋神经节神经元死亡
Xiao-Yu Song,Wan-Fu Wu,Yu-Bing Dai et al.
Xiao-Yu Song et al.
Age-related hearing loss is the most common type of hearing impairment, and is typically characterized by the loss of spiral ganglion neurons (SGNs). The two Liver X receptors (LXRs) are oxysterol-activated nuclear receptors which in adults...
Embryonic medial ganglionic eminence cells survive and integrate into the inferior colliculus of adult mice [0.03%]
胚胎侧脑室下器官腹侧区细胞在成年小鼠外侧丘系的存活和整合
Maryanna S Owoc,María E Rubio,Brian Brockway et al.
Maryanna S Owoc et al.
Acoustic overexposure can lead to decreased inhibition in auditory centers, including the inferior colliculus (IC), and has been implicated in the development of central auditory pathologies. While systemic drugs that increase GABAergic tra...
Short- and long-latency components of the eCAP reveal different refractory properties [0.03%]
短潜伏期和长潜伏期的eCAP成分显示不同的不应性属性
Yu Dong,Jeroen J Briaire,H Christiaan Stronks et al.
Yu Dong et al.
Background: The refractory recovery function (RRF) measures the electrically evoked compound action potential (eCAP) in response to a second pulse (probe) after masking by a first pulse (masker). This RRF is usually used ...
The blinking eye as a window into tinnitus: A new animal model of tinnitus in the macaque [0.03%]
猴眨眼的新动物模型研究：揭开耳鸣之谜
Lars Rogenmoser,Paweł Kuśmierek,Denis Archakov et al.
Lars Rogenmoser et al.
Tinnitus is a highly prevalent, largely untreatable auditory disorder, characterized by the perception of phantom sound often in the form of incessant ringing or hissing. Despite longstanding research with animal models, its underlying path...
Temporal integration contributes to the masking release by amplitude modulation [0.03%]
时间整合有助于幅度调制掩蔽释放效应
Hisaaki Tabuchi,Bernhard Laback
Hisaaki Tabuchi
Modulated maskers produce less amount of masking than unmodulated maskers, an effect referred to as masking release (MR). Both listening in the temporal dips and fast cochlear compression have been suggested as underlying mechanisms. We add...
Gabriel E Romero,Laurence O Trussell
Gabriel E Romero
The cochlear efferent system comprises multiple populations of brainstem neurons whose axons project to the cochlea, and whose responses to acoustic stimuli lead to regulation of auditory sensitivity. The major groups of efferent neurons ar...
Round window stimulation with an interface coupler demonstrates proof of concept [0.03%]
具有界面耦合器的圆窗刺激证明了概念的有效性
Darcy L Frear,Hideko Heidi Nakajima
Darcy L Frear
Hypothesis: To mechanically stimulate the round window (RW) membrane, an actuator with an interface coupler (IC) has the potential to improve sound transmission to the cochlea as compared to the most used RW stimulation d...