Cochlear implant imaging in the mouse and guinea pig using light-sheet microscopy [0.03%]
使用光片显微镜对小鼠和豚鼠的耳蜗植入成像
Peter A Santi,Shane Johnson,Julian Wüster et al.
Peter A Santi et al.
Postmortem examination of the cochlea with a cochlear implant in the scala tympani presents several challenges. It is technologically difficult to section a cochlea with an implant due to the presence of its wires and metal components that ...
A liquid chromatography-mass spectroscopy-based untargeted metabolomic study of the rat cochlear nucleus at various stages of maturity [0.03%]
基于液相色谱-质谱的未靶向代谢组学研究大鼠听觉神经核在不同成熟阶段的变化
Jun Tan,Yue Li,Dekun Gao et al.
Jun Tan et al.
The cochlear nucleus receives numerous inputs from auditory and nonauditory systems. This extensive innervation of the cochlear nucleus is involved in sound source localization and the integration of auditory signals with other sensory moda...
Comparison of response properties of the electrically stimulated auditory nerve reported in human listeners and in animal models [0.03%]
人在听取和动物模型中的电刺激听神经的反应特性比较研究
Jeffrey Skidmore,Dyan Ramekers,Ian C Bruce et al.
Jeffrey Skidmore et al.
Cochlear implants (CIs) provide acoustic information to implanted patients by electrically stimulating nearby auditory nerve fibers (ANFs) which then transmit the information to higher-level neural structures for further processing and inte...
Single-incision cochlear implantation and hearing evaluation in piglets and minipigs [0.03%]
猪和迷你猪单切口耳蜗植入及听力评估研究
Erdem Yildiz,Matthias Gerlitz,Anselm Joseph Gadenstaetter et al.
Erdem Yildiz et al.
Objectives: Various animal models have been established and applied in hearing research. In the exploration of novel cochlear implant developments, mainly rodents have been used. Despite their important contribution to th...
Sox2 is required in supporting cells for normal levels of vestibular hair cell regeneration in adult mice [0.03%]
Sox2是成年小鼠前庭毛细胞正常水平再生所必需的支持细胞中的一个因素
Amanda N Ciani Berlingeri,Rémy Pujol,Brandon C Cox et al.
Amanda N Ciani Berlingeri et al.
Sox2 is a transcription factor that is necessary in the mammalian inner ear for development of sensory hair cells and supporting cells. Sox2 is expressed in supporting cells of adult mammals, but its function in this context is poorly under...
Ashley Parker,Kourosh Parham,Erika Skoe
Ashley Parker
Measurement of the motor protein prestin offers a novel approach to assessing outer hair cell (OHC) status using serological techniques. Motivated by our prior work showing reduced serum prestin levels in healthy young adults at-risk for no...
Using visual speech at the cocktail-party: CNV evidence for early speech extraction in younger and older adults [0.03%]
视觉语音在鸡尾酒会上的应用：CNV证据证明了年轻和年长成年人早期的语音分离能力
Alexandra Begau,Stefan Arnau,Laura-Isabelle Klatt et al.
Alexandra Begau et al.
The comprehension of spoken language benefits from visual speech information. One reason for this is the temporal lead of mouth and lip movements over the onset of acoustic speech utterance. Here, we investigated EEG event-related potential...
Therapeutics for hearing preservation and improvement of patient outcomes in cochlear implantation-Progress and possibilities [0.03%]
人工耳蜗植入的听力保护和改善患者的治疗进展与可能
Robert D Gay,Ya Lang Enke,Jonathon R Kirk et al.
Robert D Gay et al.
The emergence of therapeutics targeted at hearing loss holds great promise in the development of novel treatments for this heterogenous condition. Whilst such therapeutics are largely designed to be efficacious in and of themselves, the pos...
Effects of an enhanced acoustic environment on residual hearing following chronic cochlear implantation and electrical stimulation in the partially deafened cat [0.03%]
慢性耳蜗植入和电信号刺激对部分聋猫残余听力增强声环境的影响研究
Andrew K Wise,Patrick Atkinson,James B Fallon
Andrew K Wise
There is an increasing trend to provide cochlear implants for people with useful residual hearing, typically in the low frequency range (4 kHz). Two separate cohorts of animals were implanted and received unilateral chronic electrical stimu...
Loss of the chromatin remodeler CHD7 impacts glial cells and myelination in the mouse cochlear spiral ganglion [0.03%]
染色质重塑因子CHD7丢失影响小鼠耳蜗螺旋神经节的胶质细胞和髓鞘形成
K Elaine Ritter,Sloane M Lynch,Ashley M Gorris et al.
K Elaine Ritter et al.
CHARGE syndrome is a multiple anomaly developmental disorder characterized by a variety of sensory deficits, including sensorineural hearing loss of unknown etiology. Most cases of CHARGE are caused by heterozygous pathogenic variants in CH...