Current development of patient-specific induced pluripotent stem cells harbouring mitochondrial gene mutations and their applications in the treatment of sensorineural hearing loss [0.03%]
携带有线粒体基因突变的患者特异性诱导多能干细胞的当前发展及其在感觉神经性听力损失治疗中的应用
Chao-Wen Chou,Yi-Chao Hsu
Chao-Wen Chou
Of all the human body's sensory systems, the auditory system is perhaps its most intricate. Hearing loss can result from even modest damage or cell death in the inner ear, and is the most common form of sensory loss. Human hearing is made p...
Virtual cochlear implantation for personalized rehabilitation of profound hearing loss [0.03%]
用于深度耳聋个性化康复的虚拟耳蜗植入技术
Daniel Schurzig,Felix Repp,Max E Timm et al.
Daniel Schurzig et al.
In cochlear implantation, current preoperative planning procedures allow for estimating how far a specific implant will reach into the inner ear of the patient, which is important to optimize hearing preservation and speech perception outco...
Characterization and Clinical Use of Bone Conduction Transducers at Extended High Frequencies [0.03%]
骨传导换能器在扩展的高频段的特征及临床应用
Aaron K Remenschneider,Jeffrey Tao Cheng,Barbara S Herrmann et al.
Aaron K Remenschneider et al.
Measurement of bone conduction (BC) hearing thresholds at extended high frequencies (EHF; above 8 kHz) is of clinical interest but is technically complicated by limitations in standard BC transducer output, a lack of calibration standards a...
Acoustic deprivation modulates central gain in human auditory brainstem and cortex [0.03%]
声学剥夺调节人类听觉脑干和皮层中的中枢增益
Peter Hutchison,Hannah Maeda,Craig Formby et al.
Peter Hutchison et al.
Beyond reduced audibility, there is convincing evidence that the auditory system adapts according to the principles of homeostatic plasticity in response to a hearing loss. Such compensatory changes include modulation of central auditory ga...
Sex differences in body composition, voluntary wheel running activity, balance performance, and auditory function in CBA/CaJ mice across the lifespan [0.03%]
CBA/CaJ小鼠一生中身体组成、自愿跑步机运动、平衡表现和听觉功能的性别差异
Mi-Jung Kim,Peter B Carmichael,Upal Bose et al.
Mi-Jung Kim et al.
Hearing loss is the third most prevalent chronic health condition affecting older adults and age-related hearing loss (ARHL) is the most common form of hearing impairment. Significant sex differences in hearing have been documented in human...
Fbxo2CreERT2: A new model for targeting cells in the neonatal and mature inner ear [0.03%]
Fbxo2CreERT2：针对新生儿和成熟内耳细胞的新模型
Melissa M McGovern,Byron Hartman,Ankita Thawani et al.
Melissa M McGovern et al.
The mammalian inner ear contains six sensory patches that allow detection of auditory stimuli as well as movement and balance. Much research has focused on the organ of Corti, the sensory organ of the cochlea that detects sound. Unfortunate...
Scaling of ear morphology across 127 bird species and its implications for hearing performance [0.03%]
跨越127种鸟类的耳部形态的变化及其对听力的影响
Jeffrey N Zeyl,Edward P Snelling,Rocío Joo et al.
Jeffrey N Zeyl et al.
The dimensions of auditory structures among animals of varying body size can have implications for hearing performance. Larger animals often have a hearing range focused on lower frequencies than smaller animals, which may be explained by s...
Mild therapeutic hypothermia protects against inflammatory and proapoptotic processes in the rat model of cochlear implant trauma [0.03%]
轻度治疗性低体温可保护大鼠耳蜗植入损伤模型免受炎症和促凋亡过程的伤害
Rachele Sangaletti,Ilmar Tamames,Stephanie Lynn Yahn et al.
Rachele Sangaletti et al.
Objective: Mild therapeutic hypothermia (MTH) has been demonstrated to prevent residual hearing loss from surgical trauma associated with cochlear implant (CI) insertion. Here, we aimed to characterize the mechanisms of M...
Three-dimensional quantification of fibrosis and ossification after cochlear implantation via virtual re-sectioning: Potential implications for residual hearing [0.03%]
耳蜗植入后纤维化和骨化的三维量化及虚拟再切片的潜在意义：对残余听力的影响
A Geerardyn,M Zhu,P Wu et al.
A Geerardyn et al.
Hearing preservation may be achieved initially in the majority of patients after cochlear implantation, however, a significant proportion of these patients experience delayed hearing loss months or years later. A prior histological report i...
J Dixon Johns,Samuel M Adadey,Michael Hoa
J Dixon Johns
The stria vascularis (SV) has been shown to play a critical role in the pathogenesis of many diseases associated with sensorineural hearing loss (SNHL), including age-related hearing loss (ARHL), noise-induced hearing loss (NIHL), hereditar...