Optimizing stimulus energy for cochlear implants with a machine learning model of the auditory nerve [0.03%]
利用机器学习的听神经模型对人工耳蜗刺激能量进行优化
Jacob de Nobel,Anna V Kononova,Jeroen J Briaire et al.
Jacob de Nobel et al.
Performing simulations with a realistic biophysical auditory nerve fiber model can be very time-consuming, due to the complex nature of the calculations involved. Here, a surrogate (approximate) model of such an auditory nerve fiber model w...
Anatomic, physiologic, and proteomic consequences of repeated microneedle-mediated perforations of the round window membrane [0.03%]
微针介导的圆窗膜反复穿孔的解剖学、生理学和蛋白质组学的影响
Stephen Leong,Aykut Aksit,Betsy Szeto et al.
Stephen Leong et al.
Background: We have developed 3D-printed microneedle technology for diagnostic aspiration of perilymph and intracochlear delivery of therapeutic agents. Single microneedle-mediated round window membrane (RWM) perforation ...
Immune responses in the mammalian inner ear and their implications for AAV-mediated inner ear gene therapy [0.03%]
哺乳动物内耳的免疫反应及其对基于腺相关病毒的内耳基因治疗的影响
Yasuko Ishibashi,Cathy Yea Won Sung,Mhamed Grati et al.
Yasuko Ishibashi et al.
Adeno-associated virus (AAV)-mediated inner ear gene therapy is a promising treatment option for hearing loss and dizziness. Several studies have shown that AAV-mediated inner ear gene therapy can be applied to various mouse models of hered...
In vivo investigation of mitochondria in lateral line afferent neurons and hair cells [0.03%]
侧线感觉神经元和毛细胞中线粒体的活体研究
Hiu-Tung C Wong,Daria Lukasz,Catherine M Drerup et al.
Hiu-Tung C Wong et al.
To process sensory stimuli, intense energy demands are placed on hair cells and primary afferents. Hair cells must both mechanotransduce and maintain pools of synaptic vesicles for neurotransmission. Furthermore, both hair cells and afferen...
Speech recognition in echoic environments and the effect of aging and hearing impairment [0.03%]
回响环境中的语音识别以及老化和听力受损的影响
Nai Ding,Jiaxin Gao,Jing Wang et al.
Nai Ding et al.
Temporal modulations provide critical cues for speech recognition. When the temporal modulations are distorted by, e.g., reverberations, speech intelligibility drops, and the drop in speech intelligibility can be explained by the amount of ...
Baruch Haimson,Adi Mizrahi
Baruch Haimson
Most animals display robust parental behaviors that support the survival and well-being of their offspring. The manifestation of parental behaviors is accompanied by physiological and hormonal changes, which affect both the body and the bra...
An overview of factors affecting bimodal and electric-acoustic stimulation (EAS) speech understanding outcomes [0.03%]
影响双模式和电声联合刺激(EAS)语音识别的因素概述
Jessica Payne,Agnes Au,Richard C Dowell
Jessica Payne
Improvements in device technology, surgical technique, and patient outcomes have resulted in a broadening of cochlear implantation criteria to consider those with increasing levels of useful low-to-mid frequency residual acoustic hearing. R...
Generation of p27icreER transgenic mice: A tool for inducible gene expression in supporting cells in the cochlea [0.03%]
p27icreER转基因小鼠的建立：耳蜗支撑细胞条件性诱导基因表达的研究工具
Yuyan Gu,Yikang Huang,Gaogan Jia et al.
Yuyan Gu et al.
The loss of cochlear hair cells (HCs) is an important cause of sensorineural hearing loss, and finding ways to regenerate HCs would be the ideal way forward for restoring hearing. In this research field, tamoxifen-inducible Cre recombinase ...
Chronic stress induced loudness hyperacusis, sound avoidance and auditory cortex hyperactivity [0.03%]
慢性压力引起的响度感音性耳聋、声音回避和听觉皮层高反应性
Senthilvelan Manohar,Guang-Di Chen,Li Li et al.
Senthilvelan Manohar et al.
Hyperacusis, a debilitating loudness intolerance disorder, has been linked to chronic stress and adrenal insufficiency. To investigate the role of chronic stress, rats were chronically treated with corticosterone (CORT) stress hormone. Chro...
Neurochemical properties for defining subdivisions of the mouse medial geniculate body [0.03%]
神经化学特性定义小鼠内侧膝状体亚区的性质
Ryohei Tomioka,Makoto Takemoto,Wen-Jie Song
Ryohei Tomioka
The medial geniculate body (MGB) exhibits anatomical and physiological properties that underlie its role in the auditory system. Anatomical properties, including myelo- and cyto-architecture, are used to identify MGB subdivisions. Recently,...